Comparative Diagnostic Pharmacology Clinical and Research Applications in Living-System Models

by Coyne, C. P.

• ISBN13: 9780813817538
• ISBN10: 0813817536
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-01-06
• Publisher: Wiley-Blackwell

Summary

Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models is the first evidence-based reference text devoted exclusively to the subject of applying pharmaceutical and biopharmaceutical agents as diagnostic probes in clinical medicine and investigative research.This unique and groundbreaking book is a versatile guide for clinicians and researchers interested in using pharmacologic agents to: * Diagnose disease * Assess physiological processes * Identify the appropriateness of a therapeutic agent * Determine appropriate dosing for therapeutic use. Extensively referenced and organized by major body systems, individual topics are listed in an evidence-based format according to specific disease processes or physiological processes of interest. Each entry also includes information on the mechanism of action, administration, and diagnostic interpretation. Descriptions have been provided for the application of diagnostic pharmaceuticals to assess a wide spectrum of diseases and physiological processes relevant to the fields of veterinary and human medicine. Comparative Diagnostic Pharmacology is useful not merely for pharmaceutical-oriented research investigations, but it will also prove invaluable for the monitoring and evaluation of physiological responses and disease processes in animal models.

Author Biography

C.P. Coyne DVM, PhD, DACVIM is a Professor of Molecular Pharmacology, at the Veterinary Pharmacology Research Laboratory, in the Department of Basic Science's Veterinary Research Program, within the College of Veterinary Medicine at Mississippi State University.

Table of Contents

Preface	ix
Journal Title Abbreviations	xi
SECTION 1 BODY SYSTEMS
Cardiovascular System	5	(56)
Cardiac Arrhythmias and EKG-Pharmacology	5	(11)
Cell Physiology	16	(5)
Cardiac Disease and Physiology	21	(15)
Angina: Cardiac-Associated Thoracic Pain	21	(8)
Angina: Non-Cardiac-Associated Thoracic Pain	29	(1)
Cardiac Diseases without Angina	30	(5)
Cardiopulmonary Physiology	35	(1)
Peripheral Vascular Disease, Function and Physiology	36	(11)
Cardiovascular Response Tests	47	(14)
Central Nervous System	61	(68)
Autonomic Nervous System	61	(1)
Peripheral Nervous System and Neuromuscular Function	62	(1)
Cerebral Cortex and Cerebral Hemispheres	63	(51)
Brainstem, Spinal Cord, and Peripheral Nervous System	114	(3)
Special Senses	117	(9)
Special Senses: Non-Ophthalmic	126	(3)
Endocrine System	129	(50)
Gastrointestinal/Pancreatic Systems	129	(1)
Hypothalamus and Pituitary: General and Miscellaneous	130	(4)
Hypothalamus, Pituitary, and Adrenal Axis	134	(16)
Hypothalamus and Pituitary: Growth Hormone	150	(14)
Hypothalamus/Pituitary Function: Reproduction	164	(6)
Hypothalamus, Pituitary, and Thyroid Axis	170	(6)
Parathyroid	176	(3)
Gastrointestinal System	179	(42)
Dentistry, Oral Cavity, and Salivary Glands	179	(2)
Esophageal Function and Disorders	181	(2)
Gastric Function and Disorders	183	(20)
Pancreas	190	(1)
Intestinal Absorption Breath Tests	190	(1)
Intestinal Absorption and Permeability: Non-Breath Tests	191	(8)
Absorption and Transit Time: Non-Carbohydrate-Based Agents	199	(4)
Permeability and Ulceration	203	(16)
Intestinal Inflammation	209	(1)
Motility and Transit Time of Intestinal Tract	210	(2)
Pancreas Function and Disease	212	(7)
Neoplasia of the Intestine and Colon	219	(2)
Hematopoietic System	221	(46)
Hematopoiesis, Hematology, and Hemostasis	221	(7)
Immune System	228	(16)
Inflammation	244	(1)
Ex Vivo Living Systems	245	(22)
Cardiovascular: Ex Vivo	245	(1)
Hepatic: Ex Vivo	246	(1)
Hematopoietic: Lymphocytes (Ex Vivo)	247	(1)
Hematopoietic: Macrophages and Monocytes (Ex Vivo)	248	(4)
Hematopoietic: Neutrophils (Ex Vivo)	252	(4)
Hematopoietic: Platelets (Ex Vivo)	256	(4)
Hematopoietic: Red Blood Cells (Ex Vivo)	260	(1)
Musculoskeletal: Ex Vivo	260	(3)
Neoplastic Disease: Ex Vivo	263	(1)
Respiratory: Ex Vivo	264	(3)
Hepatic System	267	(70)
Biliary and Hepatic Diagnostics	267	(14)
Biliary	267	(1)
Hepatobiliary	268	(1)
Hepatic Blood/Plasma Flow and Perfusion	269	(1)
Hepatic Excretory Function	269	(4)
Hepatocyte Phase I Metabolism Pathways	273	(5)
Hepatocyte Phase II Biochemical Metabolism Pathways	278	(1)
Hepatic Pathology and Disease States	279	(2)
Extrahepatic Disease Caused by Liver Dysfunction	281	(1)
Pharmacogenetics	281	(9)
Pharmacogenetics Concepts and Disease Examples	281	(8)
Pharmacogenetics: General Hepatic Biochemical Metabolization	289	(1)
Pharmacogenetics: Phase I Metabolizing Enzyme Systems	290	(24)
Microsomal Enzyme Metabolizing Capacity (General)	290	(2)
Microsomal Cytochrome P450 Enzyme Systems (General)	292	(2)
Microsomal Cytochrome P450 1 A 1 and P450 1A2	294	(2)
Microsomal Cytochromes P450 2A6, 2C9, 2C19, 2D6, and 2E1	296	(9)
Microsomal Cytochromes P450 3A	305	(6)
Hepatic Cytochrome P450 4 Microsomal Enzymes	311	(1)
Microsomal Flavin-Based Metabolizing Systems	312	(1)
Microsomal Mixed Function Oxidases	313	(1)
Phase II Metabolizing Enzyme Systems	314	(8)
Conjugation Systems	314	(8)
Extrahepatic Pharmacogenetics	322	(15)
Extrahepatic---Cardiovascular System	322	(3)
Extrahepatic---Central Nervous System	325	(4)
Extrahepatic---Renal System	329	(1)
Extrahepatic---Respiratory System	330	(1)
Extrahepatic---Musculoskeletal System	330	(2)
Pharmacogenetics of Prognosis and Therapeutic Response	332	(5)
Integumentary System	337	(4)
Musculoskeletal System	341	(10)
Bone and Synovial Structures	341	(2)
Skeletal Muscle	343	(8)
Reproductive System	351	(4)
Renal and Urinary Systems	355	(20)
Urinary Bladder	370	(2)
Imaging Enhancement	372	(3)
Respiratory System	375	(32)
Respiratory Physiology	375	(5)
Respiratory Disease Conditions	380	(18)
Breath Tests	398	(9)
SECTION 2 GENETIC DISORDERS, INFECTIOUS DISEASE, NEOPLASIA, AND METABOLIC CONDITIONS
Cancer/Neoplastic Disease	407	(18)
General	407	(2)
Central Nervous System	409	(1)
Gastrointestinal Tract	410	(5)
Endocrine	415	(5)
Immune System	420	(1)
Integumentary System	421	(2)
Musculoskeletal System	423	(1)
Renal/Urinary Systems	423	(1)
Reproductive System	423	(2)
Genetics and Nucleic Acids	425	(14)
Gene Delivery and Targeting	428	(7)
Gene Expression	435	(4)
Inflammation, Infection, and Sepsis	439	(16)
General Abscess Formation, Sepsis, and Inflammation	439	(5)
Organ- and Tissue-Associated Sepsis and Inflammatory Responses	444	(8)
Parasitology	452	(3)
Metabolism, Electrolytes, and Hypoxia	455	(18)
SECTION 3 CONTRAST AND IMAGE-ENHANCING AGENTS
Fluorescent and Pigment Dye Reagents	473	(44)
Cardiovascular System	473	(8)
Cellular: General	481	(1)
Central Nervous System and Special Senses	482	(5)
Gastrointestinal System	487	(1)
Genetic	488	(1)
Hepatic System	488	(3)
Hematology	491	(1)
Immunology	492	(1)
Membrane Characterization	493	(3)
Musculoskeletal System	496	(1)
Neoplastic Disease States	497	(10)
Special Senses	507	(2)
Pathology: General	509	(1)
Pharmaceutical Delivery	509	(2)
Renal System	511	(3)
Reproductive System	514	(1)
Respiratory System	515	(1)
Sepsis	515	(2)
Magnetic Resonance Imaging (MRI)	517	(52)
MRI: General Concepts and Principles	517	(1)
Reactions to Contrast Agents	518	(3)
Contrast Agent Profiles and Properties	521	(2)
Cardiovascular System	523	(9)
Central Nervous System	532	(12)
Central Nervous System: Special Senses	544	(1)
Gastrointestinal System	544	(1)
Genetic	545	(1)
Hematology	545	(1)
Hepatic System	546	(6)
Ischemia and Infarction	552	(1)
Musculoskeletal System	552	(3)
Neoplasia	555	(5)
Pancreas	560	(2)
Renal System	562	(1)
Respiratory System	563	(2)
Experimental Imaging Contrast-Enhancing Agents	565	(1)
Stem Cells	566	(3)
Nuclear Planar Scintigraphy	569	(108)
General	569	(1)
Amyloid and Amyloidosis	569	(3)
Apoptosis	572	(1)
Gene Expression: In Vivo Detection	573	(2)
Cardiovascular: Cardiac	575	(20)
Central Nervous System: Neurology	595	(5)
Autonomic Nervous System	600	(3)
Endocrine System	603	(3)
Gastrointestinal System	606	(3)
Hematology	609	(2)
Immune System and Inflammatory (Septic/Non-Septic) Responses	611	(11)
Integumentary System	622	(1)
Metabolic and Metabolism	622	(1)
Musculoskeletal	622	(4)
Neoplastic Disease	626	(40)
Pancreas	666	(1)
Renal System	666	(3)
Respiratory System	669	(4)
Respiratory Breath Tests: Pulmonary and Hepatic Function Assessment	673	(4)
Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT)	677	(54)
Cardiovascular System	677	(8)
Central Nervous System	685	(20)
Central Nervous System (CNS): Special Senses	705	(1)
Gene Expression	705	(1)
Hepatic System	706	(2)
Immune System	708	(1)
Inflammation and Sepsis	708	(1)
Metabolism: Hypoxia, Ischemia, Mitosis and Proliferation	709	(3)
Musculoskeletal System	712	(1)
Neoplasia	713	(18)
Radiographic Image-Enhancing Agents	731	(34)
Conventional Radiography	731	(19)
Cardiovascular System	742	(5)
Central Nervous System	747	(1)
Gastrointestinal System	747	(1)
Hepatobiliary System	748	(1)
Monocytes and Macrophages	749	(1)
Renal System	749	(1)
Reproductive System	750	(1)
Computed Tomography (CT) Radiography Image-Enhancing Agents	750	(15)
Cardiovascular System	752	(6)
Central Nervous System	758	(1)
Gastrointestinal System	759	(1)
Hepatic System	759	(1)
Inflammation and Sepsis	760	(1)
Lymph Nodes and Lymphatics	761	(1)
Neoplasia	762	(1)
Renal System	763	(1)
Respiratory System	763	(1)
Technique	764	(1)
Fluoroscopic Imaging	764	(1)
Ultrasonography	765	(46)
General Considerations and Concepts	765	(3)
Cardiovascular System	768	(20)
Central Nervous System	788	(3)
Gastrointestinal System	791	(1)
Hepatic System	792	(6)
Immune System	798	(1)
Musculoskeletal System	798	(2)
Neoplasia	800	(4)
Pancreas	804	(1)
Prostate	804	(2)
Renal System	806	(1)
Reproductive System	807	(4)
SECTION 4 DELIVERY MODALITIES
Biological and Synthetic Delivery Modalities	811	(96)
Macro-Biological Platforms	811	(9)
Cellular-Based Delivery Systems	811	(6)
Vector-Mediated Gene (Oligonucleotide) Delivery Systems	817	(3)
Macro-Synthetic Platforms	820	(49)
Liposomes	820	(25)
Microbubbles and Microspheres	845	(12)
Nanoparticles and Nanospheres	857	(12)
Molecular Platforms	869	(35)
Micro-Synthetic Agents	869	(14)
Peptides, Proteins and Immunoglobulins	883	(21)
Mechanical Platforms	904	(3)
Index	907