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9780470577547

Comparative Pathophysiology and Toxicology of Cyclooxygenases

by
  • ISBN13:

    9780470577547

  • ISBN10:

    0470577541

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2012-09-04
  • Publisher: Wiley
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Summary

A key ingredient in common pain relievers such as aspirin and Tylenol, cyclooxygenase (COX) inhibitors can pose potential risks as evidenced by Mercks highly publicized 2004 withdrawal of their drug Vioxx. This book addresses the need in the medical and scientific communities for an up-to-date resource on drug safety and the comparative aspects of prostanoids research and COX inhibitors. It offers a thorough review of COX inhibitors, their toxicity mechanisms, and clinical risks, helping scientists advance research and discovery of COX drugs, while avoiding adverse pathological and toxicological effects.

Author Biography

ZAHER A. RADI is a Research Fellow and Toxicologic Anatomic Pathologist in Drug Safety R&D at Pfizer Worldwide Research & Development. He has published over fifty-five research papers and review articles, in addition to book chapters and numerous abstracts and presentations.

Table of Contents

Introduction - Discovery of cylooxygenases and historical prospective
Gastrointestinal (GI) tract
Bone, tendon, ligament system
Renal system
Cardiovascular system
Ocular system
Respiratory system
Current research strategies for designing safer NSAIDs
Table of Contents provided by Publisher. All Rights Reserved.

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