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Computational Protein Science: Methods in Structural Bioinformatics provides understanding about the scope and power of current techniques in protein sequence-structure-function analysis and prediction, and gives insight into the intellectual achievements in protein bioinformatics. It covers sequence-to-sequence and sequence-to-structure comparison techniques, as well as algorithms for the prediction of protein structural topology and domain structure. An important focus will be discussing integrative approaches that tie various methods and data sets together. In addition to a rigorous overview, the book will emphasize the artistic elements in the analysis and prediction algorithms, and discuss their significance for addressing the outstanding problems in protein computational biology.