9780444520210

Contemporary Aspects of Boron: Chemistry and Biological Applications

by ; ;
  • ISBN13:

    9780444520210

  • ISBN10:

    044452021X

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2005-10-17
  • Publisher: Elsevier Science
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Summary

Contemporary Aspects of Boron: Chemistry and Biological Applications highlights the biological activity and applications of boron containing compounds. The authors specific approach surveys general features of the subject, while exploring new and novel strategies for preparing certain chemical and natural boron products that are of significant substance in medicinal chemistry. For example, cancer treatment is one of the most important issues related to such products. In addition to contributing to the development of new drugs by addressing biological applications in medicinal and industrial fields, the book provides a comprehensive review of the most relevant components that comprise the pharmaceutical, medicinal and environmental applications of boron containing compounds. * Timely and comprehensive * Provides new insights to active researchers in the field * Presents concepts and methods in simple scientific terms

Table of Contents

Chemistry of the diboron compounds
1(58)
H. Abu Ali
V.M. Dembitsky
M. Srebnik
Introduction
2(1)
Preparation of Diboron Compounds and their Properties
3(13)
Reactions of Diboron Compounds
16(43)
References
52(7)
Recent developments in bisdiborane chemistry: B-C-B, B-C-C-B, B-C=C-B, and B-C≡C-B compounds and their biological applications
59(60)
H. Abu Ali
V. M. Dembitsky
M. Srebnik
Introduction
60(1)
Formation of B-C-B Compounds
61(7)
Geminal Organoboron Compounds
68(17)
Formation, Reactivity and Biological Activity of B-C-C-B, B-C=C-B, and B-C≡C-B Compounds
85(34)
References
113(6)
Applied Suzuki cross-coupling reaction for syntheses of biologically active compounds
119(180)
V.M. Dembitsky
H. Abu Ali
M. Srebnik
Introduction
120(1)
Synthesis of Biologically Active Compounds via Cross Coupling Reaction Catalyzed by Palladium
120(13)
Cross-coupling of Alkynylborane Derivatives with Haloarenes
133(22)
Cross-coupling of Alkynylborane Derivatives
155(11)
Cross-coupling of Alkylborane Derivatives
166(18)
Synthesis of Macrocycles
184(38)
Modification of Nucleosides using Suzuki-Miyaura Coupling
222(14)
Synthesis of Substituted Porphyrins
236(5)
Additional Application of the Suzuki Cross-coupling Reaction
241(2)
Synthesis of Macrocyclic Compounds
243(7)
Synthesis of Tetracyclic Systems
250(11)
Synthesis of Polycyclic Ethers
261(6)
Synthesis of Disubstituted Furans
267(3)
Synthesis of GeranylGeranyl Diphosphate Derivatives
270(1)
Synthesis of Spiroquinolizidine Derivatives
271(2)
Synthesis of Carbohydrate-Substituted Phosphines
273(7)
Synthesis of Novel Thyroid Hormone Analogues: 5'-Aryl Substituted GC-1 Derivatives
280(19)
References
282(17)
Synthesis of selected biologically active compounds via allylboration
299(38)
V. M. Dembitsky
H. Abu Ali
M. Srebnik
Introduction
300(1)
Synthesis of Heterocyclic Compounds
301(18)
Synthesis of N-Lactone Rings
319(7)
Allylboration of Nitrogen Heterocycles
326(11)
References
331(6)
Boron neutron capture therapy
337(30)
A. K. Azab
H. Abu Ali
M. Srebnik
Introduction
338(1)
The Concept of Boron Neutron Capture Therapy
338(3)
BNCT in the Treatment of Cancer
341(3)
Boron Targeting to Cancer Tissues
344(16)
Summary
360(7)
References
361(6)
Boron enolates in the syntheses of natural products
367(24)
V. M. Dembitsky
H. Abu Ali
M. Srebnik
Introduction
369(1)
Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide
369(1)
Enantioselective Total Synthesis of (+)-Leucascandrolide- A Macrolactone
370(1)
Synthesis of the C29-C51 Subunit of Altohyrtin C (Spongistatin 2)
371(1)
Asymmetric Synthesis of the Polyene Macrolide Antibiotic RK-397
372(1)
Asymmetric Total Synthesis of Spongistatins 1 and 2
372(1)
Synthesis of the Microtubule-Stabilizing Agent (-)-Laulimalide
373(1)
Synthesis of (2S,3S)- and (2R,3R)-β-Hydroxyornithine
374(1)
Synthesis of Concanamycin F
374(1)
Synthesis of an Isomer of Membrenone C
375(1)
Synthesis of Doliculide
376(1)
Synthesis of Tri- and Tetrapeptide S: the Extended C-Terminus of Bleomycin A2
376(1)
Synthesis of A (9S)-Macrolide Intermediate for Oleandomycin
377(1)
Synthetic Studies on Antitumor Antibiotic Bleomycin
377(1)
Synthesis of the Esterase Inhibitor (±)- Ebelactone A
378(1)
Synthesis of the Oviposition-Deterring Pheromone in Rhagoletis cerasi
378(1)
Synthesis of (±)-Hernandulcin
379(1)
Synthesis of β-Lactam Antibiotics
379(1)
Synthesis of (+)-Pseudomonic Acid C
380(1)
Synthesis of Masamune Norephedrine Esters
381(1)
Synthesis of L-Daunosamine and D-Ristosamine Derivatives
381(1)
SEMI- Synthesis of Taxol
382(1)
Synthesis of the Pyrrolizidine Ring System
382(1)
Synthesis of (-)-Branched Unusual Amino Acids
383(1)
Synthesis of a-Amino Acids
383(1)
Synthesis of 1-β-Methylcarbapenem Antibiotics
384(1)
Synthesis of Nakadomarin
385(1)
Synthesis of 11-β, 17-β-Diaryl-18A-Homo-19-Norsteroids
385(1)
Synthesis of the Central C18-C30 Core of the Phorboxazole
386(1)
Synthesis of A C17-C32 Subunit of Scytophycin C
386(1)
Synthesis of the Archaebacterial C40 Diol
387(1)
Synthesis of Anthracycline Glycosides
387(4)
References
388(3)
Boronated saccharides: potential applications
391(104)
R. Smoum
M. Srebnik
Introduction
393(1)
Boronic Acids-Saccharide Interaction; the Basics
393(3)
Chemosensing
396(38)
Transport
434(12)
Boron and Plants
446(5)
Chromatography
451(10)
Boron and Diabetes
461(4)
Boron and Cancer
465(5)
Drug Delivery
470(2)
Miscellaneous Biological Applications of Boron Saccharide Interactions
472(23)
References
479(16)
α-Aminoboronic acids, amine cyanoboranes, amine carboxyboranes and their derivatives
495(56)
K. Takrouri
V.M. Dembistky
M. Srebnik
Introduction
496(1)
α-Aminoboronic Acids
496(26)
Amine Cyanoboranes and Amine Carboxyboranes
522(15)
Biological Activities of Amine Cyano- and Carboxyboranes and their Derivatives
537(14)
References
544(7)
Environmental aspects of boron
551(48)
A. Shibli
M. Srebnik
Introduction
552(1)
Boron Chemistry
553(7)
Boron in Soils
560(2)
Boron in Plants
562(18)
Water Desalination
580(19)
References
593(6)
Index 599

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