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An essential text for every organic chemist in academia and industry involved in the synthesis of natural products or commercial pharmaceutical targets.
Simon Woodward is a Professor in Synthetic Organic Chemistry at Nottingham University, UK. He has been Director of both The European Ligand Bank (a facility for the exchange of ligand ideas between groups interested in selective catalysis, 2004-present) and an International Marie Curie Ph.D. School (INDAC-CHEM, 2007-2010) in "Catalysis of Organic Reactions" encompassing the Universities of Nottingham, Geneva, Sassari and Dortmund. He is also the Chair of the European Cooperation in Science and Technology (COST) action D40 in "Innovative Catalysis" (2006-2011) and a member action CM0903 in "Biomass Utilisation". The flexibility of his research group is highly strengthened by extensive collaborative with over 20 other groups, both throughout Europe and beyond, involved in the selective catalysis of organic reactions. He has authored over 110 publications in the areas of organic methodology, organometallic chemistry, and selective/asymmetric catalysis.
Norbert Krause graduated from Technical University of Braunschweig, Germany, in 1984 and received his PhD in 1986. After postdoctoral stays at the ETH Z?rich and Yale University, he joined the Technical University of Darmstadt and obtained his Habilitation in 1993. In 1994, he moved to the University of Bonn as Associate Professor, before being appointed to his present position at Dortmund University of Technology as Full Professor in 1998. He was a Fellow of the Japan Society for the Promotion of Science (2003 and 2009), and Guest Professor at the Universit? Catholique de Louvain, Belgium (2007), at the University of California, Santa Barbara, USA (2009), and at the ?cole Sup?rieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), France (2009). Since 2006, he is a member of the Editorial Board of the European Journal of Organic Chemistry. His review on "Recent Advances in Catalytic Enantioselective Michael Additions" was the World's Most Cited Chemistry Paper in Nov. 2002. His research focuses on the stereoselective synthesis and transformation of functionalized allenes, taking advantage of coinage metal (copper, silver, and gold) catalysis.
Table of Contents
The Primary Organometallic in Copper Catalyzed Reactions
Asymmetric Conjugate Addition (1,4)
Conjugate Addition to Extended Michael Acceptors
Asymmetric Allylic Alkylation
Opening of Epoxides and Related Systems
CuH in Asymmetric Reductions
Asymmetric Cyclopropanation Reactions
Copper in Lewis Acid Catalyzed Reactions
Mechanistic Aspects of Copper Catalyzed Reactions
Applications to the Synthesis of Natural Products