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This unique and timely book provides an invaluable overview of the most significant developments in the area of asymmetric copper-catalyzed reactions over the past ten years. A team of internationally renowned editors has put together contributions from leaders in the field, resulting in a detailed account of current applications as well as mechanistic and spectroscopic aspects. An essential text for every organic chemist in academia and industry involved in the synthesis of natural products or commercial pharmaceutical targets.
Alexandre Alexakis is a Professor of Organic Chemistry at the University of Geneva, Switzerland. He graduated from Paris VI University in 1970 and received his PhD in 1975. After a postdoctoral stay at Johns Hopkins University, Baltimore (USA), he joined the CNRS at Pierre et Marie Curie University in 1977, being appointed Directeur de Recherche in 1985. In 1994 he was awarded the Silver Medal of the CNRS. In 1996 he moved from CNRS to Pierre et Marie Curie University as full Professor (1st class), then to the University of Geneva in 1998. In 2002 he was awarded the Novartis Lectureship Award. His research focuses on asymmetric synthesis and methodologies, using both metal catalysts, particularly copper reagents, and non-metallic catalysts (organocatalysis). He is the author of 300 articles.
Simon Woodward is a Professor in Synthetic Organic Chemistry at Nottingham University, UK. He has been Director of both The European Ligand Bank (a facility for the exchange of ligand ideas between groups interested in selective catalysis, 2004-present) and an International Marie Curie Ph.D. School (INDAC-CHEM, 2007-2010) in "Catalysis of Organic Reactions" encompassing the Universities of Nottingham, Geneva, Sassari and Dortmund. He is also the Chair of the European Cooperation in Science and Technology (COST) action D40 in "Innovative Catalysis" (2006-2011) and a member action CM0903 in "Biomass Utilisation". The flexibility of his research group is highly strengthened by extensive collaborative with over 20 other groups, both throughout Europe and beyond, involved in the selective catalysis of organic reactions. He has authored over 110 publications in the areas of organic methodology, organometallic chemistry, and selective/asymmetric catalysis.
Norbert Krause graduated from Technical University of Braunschweig, Germany, in 1984 and received his PhD in 1986. After postdoctoral stays at the ETH Z?rich and Yale University, he joined the Technical University of Darmstadt and obtained his Habilitation in 1993. In 1994, he moved to the University of Bonn as Associate Professor, before being appointed to his present position at Dortmund University of Technology as Full Professor in 1998. He was a Fellow of the Japan Society for the Promotion of Science (2003 and 2009), and Guest Professor at the Universit? Catholique de Louvain, Belgium (2007), at the University of California, Santa Barbara, USA (2009), and at the ?cole Sup?rieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), France (2009). Since 2006, he is a member of the Editorial Board of the European Journal of Organic Chemistry. His review on "Recent Advances in Catalytic Enantioselective Michael Additions" was the World's Most Cited Chemistry Paper in Nov. 2002. His research focuses on the stereoselective synthesis and transformation of functionalized allenes, taking advantage of coinage metal (copper, silver, and gold) catalysis.
Table of Contents
Introduction The Primary Organometallic in Copper Catalyzed Reactions Asymmetric Conjugate Addition (1,4) Conjugate Addition to Extended Michael Acceptors Asymmetric Allylic Alkylation Opening of Epoxides and Related Systems Non-Carbon Nucleophiles CuH in Asymmetric Reductions Asymmetric Cyclopropanation Reactions Copper in Lewis Acid Catalyzed Reactions Mechanistic Aspects of Copper Catalyzed Reactions Spectroscopic Aspects Applications to the Synthesis of Natural Products