Crystallization : Basic Concepts and Industrial Applications

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  • Format: Hardcover
  • Copyright: 4/1/2013
  • Publisher: Vch Pub
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With its content stemming from tried and tested course notes, this book draws on the expertise from authors based at leading pharmaceutical companies such as Bayer, AstraZeneca and Novartis, as well as leading academic institutions. As such, it represents the perfect blend of theoretical background and application-oriented discussions, including the latest research developments and industrial examples. In the first section, the basic mechanisms are introduced, ensuring an understanding of supersaturation. In addition, the solubility of the substance and its dependences on process conditions and the various techniques of crystallization and their possibilities and limitations are discussed. The second part builds on the basics, exploring how crystallization processes can be developed, either batch-wise or continuous, from solution or from the melt. The two sections are bridged by a discussion of the purification during crystallization, where practical aspects and an insight using theoretical concepts are combined. The third part of the book is dedicated to accounts of actual developments and successful crystallizations, outlining typical pitfalls and strategies to avoid them, as well as to the design of robust processes.

Author Biography

Wolfgang Beckmann is Senior Scientist at Bayer Technologies. Dr. Beckmann studied Chemical Engineering and Physical Chemistry in Germany and the US. He spent one year as Postdoctoral Fellow in Marseille.
Wolfgang Beckmann has spent the last 20 years working at Bayer and prior to this at Schering, developing crystallization processes for pharmaceutical compounds. He has authored 3 chapters in books and approximately 50 publications in reviewed journals.

Table of Contents

Basics of Crystallization
Mechanisms of Crystallization
Solubility -
Phase Diagrams
Agglomeration Phenomena during Crystallization
Polymorphism of Crystalline Systems
Influence of Impurities on Crystallization
Purification by Crystallization
Characterization of Crystalline Products
Design of Crystallization Processes
Development of Crystallization Processes
Batch Crystallizers
Continuous Crystallizers
Down-Stream Processes
Crystallization from the Melt
Design Examples of Crystallizations
Batch -
Crystallizations from Solutions
Example of Completed Continuous Crystallization
Design Examples of Melt Crystallizations
Examples of Purification via Crystallization
Table of Contents provided by Publisher. All Rights Reserved.

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