Diagnostic Pediatric Hematopathology

by Edited by Maria A. Proytcheva

• ISBN13: 9780521881609
• ISBN10: 0521881609
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-03-14
• Publisher: Cambridge University Press

Summary

Diagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, United Kingdom, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists.

Table of Contents

Introduction

General and Non-Neoplastic Hematopathology

Hematologic values in the healthy fetus, neonate, and child

Normal bone marrow

Disorders of erythrocyte production: nutritional deficiencies, iron deficient, and sideroblastic anemia

Disorders of hemoglobin synthesis: thalassemias and structural hemoglobinopathies

Hemolytic anemias: immune- and non-immune-mediated hemolytic anemias, RBC membrane defects, and hereditary disorders due to RBC enzyme defects

Inherited and acquired bone marrow failure syndromes associated with multiple cytopenias

Inherited bone marrow failure syndromes and acquired disorders associated with single peripheral blood cytopenia: pure red cell aplasia, agranulocytosis, and thrombocytopenias

Peripheral blood and bone marrow manifestations of metabolite storage diseases

Reactive lymphadenopathies

Neoplastic Hematopathology

Chromosome abnormalities of hematologic malignancies: a practical guide to cytogenetic analysis

Expression profiling in pediatric acute leukemias

Myeloproliferative neoplasms

Myelodysplastic/myeloproliferative neoplasms

Myelodysplastic syndromes and therapy-related myeloid neoplasms

Acute myeloid leukemia and related precursor neoplasms

Hematologic abnormalities in individuals with Down syndrome

Precursor lymphoid neoplasms

Advances in prognostication and treatment of pediatric acute leukemia

The effect of chemotherapy, detection of minimal residual disease, and hematopoietic stem cell transplantation

Pediatric small blue cell tumors metastatic to the bone marrow

Pediatric mature B-cell non-Hodgkin lymphomas

Pediatric mature T-cell and NK-cell non-Hodgkin lymphomas

Hodgkin lymphoma

Immunodeficiency-associated lymphoproliferative disorders: congenital immune deficiencies, acquired immune deficiencies, and post-transplant lymphoproliferative disorders

Histiocytic proliferations in childhood

Cutaneous and subcutaneous lymphomas in children

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