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In a city so dismal it's known only as "the Hole," a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.
After an emotional reunion with Caiman, Nikaido receives a cryptic hint from a mysterious Devil on how to escape from deep within the Central Department Store. Meanwhile, with the En family spread about a bleak landscape, Fulita, Chota and Turkey must attempt to get the situation back on their terms. And now, in the shadow of a Devil vs. Devil battle, no one can catch the boss as he drags his secretive tube, while the Central Department Store is becoming more and more confusing. Who will be left standing at the end?
Known for her bold style and seamless creation of alternate universes, QHayashida made her manga debut with Maken X Another, which ran in Magazine Z and was subsequently adapted into a video game. She followed this series with a sequel, Maken X Another Jack. Dorohedoro is her latest series.