9780748406876

Electrically Assisted Transdermal and Topical Drug Delivery : Metabolism and Molecular Physiology of Saccharomyces

by
  • ISBN13:

    9780748406876

  • ISBN10:

    0748406875

  • Format: Hardcover
  • Copyright: 1998-09-01
  • Publisher: CRC

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Supplemental Materials

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Summary

This volume provides coverage of assisted transdermal and topical delivery by the mechanisms of iontophoresis, electro-osmosis and electroporation. The book starts by introducing the terminology and outlines the historical background. It then goes on to present a foundation of the theoretical concepts and mechanisms of iontophoresis and electroporation, followed by tips on the design of experimental systems for research in this area. This book provides a wealth of theoretical and practical information not easily found in any other single source.

Table of Contents

Preface ix
About the author xi
Percutaneous absorption and its enhancement
1(12)
Introduction
1(1)
Structure, enzymatic activity and immunology of the skin
2(3)
Percutaneous absorption
5(2)
Iontophoretic enhancement of percutaneous absorption
7(3)
Other methods for enhancement of percutaneous absorption
10(3)
Iontophoretic transdermal drug delivery
13(20)
Introduction
13(1)
Electrical properties of the skin
13(2)
Pathways of iontophoretic drug delivery
15(1)
Theoretical basis of iontophoresis
16(2)
Factors affecting iontophoretic delivery
18(6)
Electro-osmotic flow
24(2)
Reverse iontophoresis
26(2)
Case studies
28(5)
In vitro experimental techniques for iontophoresis research in the laboratory
33(24)
Introduction
33(1)
Selection of skin or membrane
33(4)
In vitro transdermal iontophoresis studies
37(6)
pH control in iontophoresis research
43(5)
Novel formulations for iontophoretic delivery
48(9)
Clinical applications of iontophoresis devices for topical dermatological delivery
57(18)
Introduction
57(1)
Clinical applications of iontophoresis
57(11)
Iontophoresis devices
68(3)
Electrode design
71(2)
Treatment protocols and formulations
73(2)
Iontophoretic delivery of peptides
75(20)
Introduction
75(2)
Structural considerations of polypeptides relevant to iontophoretic delivery
77(1)
Peptides as iontophoresis candidates
78(1)
Protease inhibitors and permeation enhancers for iontophoretic delivery
79(3)
Case studies
82(8)
Iontophoretic delivery of insulin: fact or fiction?
90(5)
Transdermal delivery by electroporation
95(14)
Introduction
95(2)
Electropermeabilization of the skin
97(1)
Electroporation equipment
98(2)
Factors affecting delivery by electroporation
100(2)
Pulsatile delivery of drugs by electroporation
102(1)
Skin toxicology of electroporation
103(2)
Delivery of particulates into the skin
105(1)
Electroporation for cancer chemotherapy
106(1)
Commercial development of electroporation
107(2)
Electrically assisted delivery of gene-based drugs to skin
109(10)
Introduction
109(1)
Delivery of oligonucleotides
110(2)
Delivery of genes
112(3)
DNA vaccines
115(4)
Developmental issues and commercialization of wearable iontophoretic patches
119(16)
Introduction
119(4)
Human studies
123(2)
Dose and bioavailability
125(1)
Biological and safety issues
126(2)
Skin damage and its measurement
128(2)
Patch design and manufacture
130(2)
Developmental and regulatory issues
132(3)
Bibliography 135(36)
Index 171

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