Electroporation-Based Therapies for Cancer

by Sundararajan

• ISBN13: 9781907568152
• ISBN10: 1907568158
• Edition: 1st
• Format: Paperback
• Copyright: 2018-10-30
• Publisher: Elsevier Science

Summary

There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring and chemo-resistant cancers, that do not respond well to current treatment regimen. Electrical-pulse-mediated, enhanced drug delivery technique, known as electroporation is one of the ways to effectively treat these patients. Towards this end, this book provides a comprehensive overview of electroporation-based clinical studies in the hospitals for various cancer treatments including melanomas, head and neck cancers, chest wall breast carcinomas and colorectal cancers and research studies in the lab using cell lines, primary cells, and animals. This technique is especially suitable for low and middle-income countries, where due to lack of infrastructure and resources, many cancers are diagnosed at late stages and this safe, effective, economical, out-patient-based and quick (it only takes a few minutes to treat a tumor) technique is a boon to these patients for palliative and other care with enhanced quality of life. From basics to clinical medical applications of electroporation are discussed by interdisciplinary authors including practicing oncological surgeons, medical professional, and academic and other researchers.