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This is an up-to-date review of the epidemiology of childhood cancers. The text is divided into three parts with Part 1 designed to introduce the reader to the descriptive epidemiology, clinical aspects, and biologic basis of childhood cancers. This section also provides a detailed account of the methodological issues involved in the epidemiologic study of pediatric cancers. Part 2 provides an overview of the epidemiology of the various cancer types affecting children, while Part 3 provides a detailed review of the genetics of childhood cancers and the possible role of various environmental exposures in their etiology. It will also contain a glossary and a list of Internet sites where additional information and data on childhood cancers can be obtained.