Epigenetic Regulation in the Nervous System

by Sweatt; Meaney; Nestler; Akbarian

• ISBN13: 9780123914941
• ISBN10: 0123914949
• Edition: 1st
• Format: Hardcover
• Copyright: 2013-02-08
• Publisher: Elsevier Science

Summary

Behavioral Epigenetics is the study of how environmental factors affect alterations in behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcome. With an understanding of the molecular mechanisms involved in epigenetic modulation, researchers believe it will be possible to develop targeted therapies for those individuals in whom it malfunctions. This volume will address current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. It will span molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and will be unique in its incorporation of epigenetically based disorders of the CNS. Edited by the most highly regarded leaders in the field, the volume will offer a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material and specific topics of emerging excitement, it will serve as both a cutting edge resource and a foundational reference. Neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior will benefit, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. * Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between * Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists * Edited and authored by the leaders in the field around the globe - the broadest, most expert coverage available * Provides numerous practical examples for the new investigator to facilitate implementation of research in the neuroepigenetics area