Essential Cell Biology

by Alberts, Bruce

• ISBN13: 9780815334811
• ISBN10: 0815334818
• Edition: 2nd
• Format: Paperback
• Copyright: 2003-09-25
• Publisher: Garland Science

Author Biography

Bruce Alberts received his Ph.D. from Harvard University and is President of the National Academy of Sciences and Professor of Biochemistry and Biophysics at the University of California, San Francisco Dennis Bray received his Ph.D. from Massachusetts Institute of Technology and is currently a Medical Research Council Fellow in the Department of Zoology, University of Cambridge Karen Hopkin received her Ph.D. in biochemistry from the Albert Einstein College of Medicine in the Bronx and is a science writer in Cambridge, Massachusetts Alexander Johnson received his Ph.D. from Harvard University and is a Professor of Microbiology and Immunology and Co-Director of the Biochemistry and Molecular Biology Program at the University of California, San Francisco. Julian Lewis received his D.Phil. from the University of Oxford and is a Principal Scientist at the London Research Institute of Cancer Research UK Martin Raff received his M.D. from McGill University and is at the Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and in the Biology Department at University College London Keith Roberts received his Ph.D. from the University of Cambridge and is Associate Research Director at the John Innes Centre, Norwich Peter Walter received his Ph.D. from The Rockefeller University in New York and is Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco, and an Investigator of the Howard Hughes Medical Institute

Table of Contents

Introduction to Cells	p. 1
Light and electron microscopy	p. 8
Cells: the principal features of animal, plant, and bacterial cells	p. 25
How We Know: Life's common mechanisms	p. 30
Chemical Components of Cells	p. 39
How We Know: What are macromolecules?	p. 60
Chemical bonds and groups	p. 66
The chemical properties of water	p. 68
An outline of some of the types of sugars	p. 70
Fatty acids and other lipids	p. 72
The 20 amino acids found in proteins	p. 74
A survey of the nucleotides	p. 76
The principal types of weak noncovalent bonds	p. 78
Energy, Catalysis, and Biosynthesis	p. 83
Free energy and biological reactions	p. 96
How We Know: Using kinetics to model and manipulate metabolic pathways	p. 103
Protein Structure and Function	p. 119
A few examples of some general protein functions	p. 120
How We Know: Probing protein structure	p. 129
Four different ways of depicting a small protein	p. 132
Cell breakage and initial fractionation of cell extracts	p. 160
Protein separation by chromatography	p. 162
Protein separation by electrophoresis	p. 163
Making and using antibodies	p. 164
DNA and Chromosomes	p. 169
How We Know: Genes are made of DNA	p. 172
DNA Replication, Repair, and Recombination	p. 195
How We Know: Finding replication origins	p. 198
From DNA to Protein: How Cells Read the Genome	p. 229
How We Know: Cracking the genetic code	p. 246
Control of Gene Expression	p. 267
How We Know: Gene regulation--the story of eve	p. 282
How Genes and Genomes Evolve	p. 293
How We Know: Counting genes	p. 314
Manipulating Genes and Cells	p. 323
How We Know: Sequencing the human genome	p. 334
Membrane Structure	p. 365
How We Know: Measuring membrane flow	p. 384
Membrane Transport	p. 389
How We Know: Squid reveal secrets of membrane excitability	p. 414
How Cells Obtain Energy from Food	p. 427
Details of the 10 steps of glycolysis	p. 432
How We Know: Unraveling the citric acid cycle	p. 442
The complete citric acid cycle	p. 450
Energy Generation in Mitochondria and Chloroplasts	p. 453
How We Know: How chemiosmotic coupling drives ATP synthesis	p. 460
Redox potentials	p. 471
Intracellular Compartments and Transport	p. 497
How We Know: Tracking protein and vesicle transport	p. 520
Cell Communication	p. 533
How We Know: Untangling cell signaling pathways	p. 561
Cytoskeleton	p. 573
How We Know: Pursuing motor proteins	p. 586
Cell-Cycle Control and Cell Death	p. 611
How We Know: Discovery of cyclins and Cdks	p. 618
Cell Division	p. 637
The principal stages of M phase in an animal cell	p. 642
How We Know: Building the mitotic spindle	p. 646
Genetics, Meiosis, and the Molecular Basis of Heredity	p. 659
How We Know: Reading genetic linkage maps	p. 682
Some essentials of classical genetics	p. 685
Tissues and Cancer	p. 697
The cell types and tissues from which higher plants are constructed	p. 700
How We Know: Making sense of the genes that are critical for cancer	p. 734
Answers to Questions	p. A:1
Glossary	p. G:1
Index	p. I:1
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