Fatty Liver Disease NASH and Related Disorders

by Farrell, Geoffrey C.; George, Jacob; Hall, Pauline de la M.; McCullough, Arthur J.

• ISBN13: 9781405112925
• ISBN10: 1405112921
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-12-10
• Publisher: Wiley-Blackwell

Summary

Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It appeals to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease. It will improve your diagnostic acumen for people with abnormal liver tests, advance your knowledge about this important subject and help with your specialist or undergraduate exams, and management of a common disorder.

Author Biography

Geoff Farrell, Professor of Hepatic Medicine, Director of Gastroenterology, The Canberra Hospital, Australia
Geoffrey Farrell graduated MB BS from the University of Tasmania in 1970, and trained in gastroenterology and hepatology at the Royal Prince Alfred and Royal Brisbane Hospitals, the latter with Lawrie Powell with whom he completed an MD on hepatic drug metabolism. He was awarded an NHMRC CJ Martin Fellowship to conduct post-doctoral research in UCSF, and in 1980 returned to Sydney to establish a Liver Research Group at Westmead Hospital. He was promoted to a personal chair in 1993, then accepted the Storr Chair in Hepatic Medicine. He remained Director of the Storr Liver Unit until Jan 2006, when he accepted the position as Professor of Hepatic Medicine with ANU Medical School and Director of Gastroenterology and Hepatology at The Canberra Hospital. He has held many leadership roles in medical research, gastroenterology, editorial boards, and academic medicine, including Editor-in-Chief of Journal of Gastroenterology and Hepatology since November 2006.
Geoff Farrell's research interests are in non-alcoholic steatohepatitis, viral hepatitis, drug-induced liver injury, and liver regeneration. He has published 3 books, including the first on non-alcoholic fatty liver disease, and written more than 180 scientific papers and 100 reviews/chapters and editorials in the fields of hepatology and biochemical pharmacology. His work is very highly cited, with an H-index of 50, more than 20 articles cited >100 times, average citation 32 per paper, and 15 articles being the subject of editorials in major medical journals. He is CIA on an NHMRC Program Grant to study the molecular and cellular basis of liver disease, and has recently held a Centre for Clinical Research Excellence Program grant to improve outcomes for patients with liver disease.

Jacob George is the editor of Fatty Liver Disease: NASH and Related Disorders, published by Wiley.

Pauline de la M. Hall is the editor of Fatty Liver Disease: NASH and Related Disorders, published by Wiley.

Arthur McCullough, Department Chair of Gastroenterology and Hepatology, Cleveland Clinic, USA
Arthur McCullough, MD, is Department Chair of Gastroenterology and Hepatology and a Staff Physician in the Department of Pathobiology and Transplantation Center at Cleveland Clinic. He was appointed in 2006. He attended medical school at SUNY Health Science Center at University Hospital of Syracuse, N.Y. He completed his internship and residency at Cleveland Clinic and a fellowship at Mayo Clinic in Rochester, Minn.
He is one of the most senior hepatologists in the United States and is the current President of the American Association for the Study of Liver Diseases. Other significant achievements are: Best Doctor's in America: "Midwest Region" annually from 1996-2008; Chair of the NIH-funded Clinical Research Network on Fatty Liver Disease (federal funding); NIH Grant on Omega 3 Fatty Acids in Diabetes (federal funding); New Novel Agents for Hepatitis C Patients who failed to respond to previous therapy (non-federal funding).

Table of Contents

Contributors	vii
Preface	x
Overview: an introduction to Nash and related fatty liver disorders	1	(12)
Geoffrey C. Farrell
Jacob George
Pauline de la M. Hall
Arthur J. McCullough
Pathology of hepatic steatosis, Nash and related conditions	13	(10)
Pauline de la M. Hall
Richard Kirsch
The epidemiology and risk factors of Nash	23	(15)
Arthur J. McCullough
Insulin resistance in NAFLD: potential mechanisms and therapies	38	(17)
Varman T. Samuel
Gerald I. Shulman
Nash as part of the metabolic (insulin resistance) syndrome	55	(11)
Giulio Marchesini
Elisabetta Bugianesi
Nash is a genetically determined disease	66	(10)
Christopher P. Day
Ann K. Daly
The pathogenesis of Nash: human studies	76	(15)
Arun J. Sanyal
Animal models of steatohepatitis	91	(18)
Geoffrey C. Farrell
Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/Nash	109	(14)
Nathan M. Bass
Raphael B. Merriman
Cytokines and inflammatory recruitment in Nash: experimental and human studies	123	(9)
Zhiping Li
Anna-Mae Diehl
Mitochondrial injury and Nash	132	(11)
Bernard Fromenty
Dominique Pessayre
Cell biology of Nash: fibrosis and cell proliferation	143	(16)
Isabelle A. Leclercq
Yves Horsmans
Clinical manifestations and diagnosis of NAFLD	159	(9)
Stephen A. Harrison
Brent Neuschwander-Tetri
The clinical outcome of NAFLD including cryptogenic cirrhosis	168	(13)
Stephen H. Caldwell
Anita Impagliazzo Hylton
Practical approach to the diagnosis and management of people with fatty liver diseases	181	(13)
Jacob George
Geoffrey C. Farrell
Management of Nash: current and future perspectives on treatment	194	(14)
Paul Angulo
Keith D. Lindor
NAFLD, Nash and orthotopic liver transplantation	208	(10)
Anne Burke
Michael R. Lucey
NAFLD/Nash is not just a `Western' problem: some perspectives on NAFLD/Nash from the East	218	(11)
Shivakumar Chitturi
Jacob George
NAFLD/Nash in children	229	(12)
Joel E. Lavine
Jeffrey B. Schwimmer
Steatohepatitis resulting from intestinal bypass	241	(8)
Christiane Bode
J. Christian Bode
Specific disorders associated with NAFLD	249	(14)
Geraldine M. Grant
Vikas Chandhoke
Zobair M. Younossi
Hepatocellular carcinoma in NAFLD	263	(13)
Vlad Ratziu
Thierry Poynard
Does Nash or NAFLD contribute to comorbidity of other liver diseases?	276	(13)
Andrew D. Clouston
Elizabeth E. Powell
Recent advances	289	(14)
Richard Kirsch
Pauline de la M. Hall
Jacob George
Arthur J. McCullough
Geoffrey C. Farrell
Index	303