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Foye's Principles of Medicinal Chemistry,9780683307375
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Foye's Principles of Medicinal Chemistry

by ; ;
Edition:
5th
ISBN13:

9780683307375

ISBN10:
0683307371
Format:
Hardcover
Pub. Date:
2/15/2002
Publisher(s):
LIPPINCOTT WILLIAMS & WILKINS
List Price: $92.74
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Summary

This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.

Table of Contents

Introduction Origins of Medicinal Chemistry 1(10)
William O. Foye
Part I Principles of Drug Discovery 11(234)
Overview Drug Design and Development: A Perspective
12(12)
Michael Williams
Natural Products
24(13)
Alice M. Clark
Drug Design and Relationship of Functional Groups to Pharmacologic Activity
37(31)
James J. Knittel
Robin M. Zavod
Molecular Modeling and Drug Design
68(18)
Eric Billings
Receptors and Drug Action
86(14)
Timothy J. Maher
David A. Johnson
Drug Design Through Enzyme Inhibition
100(14)
Stephen G. Kerr
Peptide and Protein Drugs
114(29)
Michael Mokotoff
Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics
143(31)
Sunil Jambhekar
Drug Metabolism
174(60)
David A. Williams
U.S. Drug Regulation: An Overview
234(11)
Douglas J. Pisano
Part II Pharmacodynamic Agents 245(19)
Overview Drug Receptors: A Perspective
246(18)
David J. Triggle
Section 1 Drugs Affecting Neurotransmission 264(93)
Drugs Affecting Cholinergic Neurotransmission
264(28)
Danny L. Lattin
E. Kim Fifer
Drugs Affecting Adrenergic Neurotransmission
292(23)
Robert Griffith
Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission
315(23)
Richard A. Glennon
Malgorzata Dukat
Local Anesthetics
338(19)
Matthias C. Lu
Section 2 Drugs Affecting Central Nervous System 357(140)
Volatile Anesthetics
357(13)
Timothy J. Maher
Hypnotics
370(14)
William Soine
Antiseizure Drugs
384(24)
Barbara W. Leduc
Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents
408(26)
Raymond G. Booth
John L. Neumeyer
Hallucinogens, Stimulants, and Related Drugs of Abuse
434(19)
Richard A. Glennon
Opioid Analgesics
453(27)
David S. Fries
Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents
480(17)
Raymond G. Booth
John L. Neumeyer
Section 3 Drugs Affecting the Cardiovascular System 497(132)
Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs
497(21)
Ahmed S. Mehanna
Diuretics
518(15)
Gary O. Rankin
Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers
533(29)
Marc W. Harrold
Central and Peripheral Sympatholytics and Vasodilators
562(18)
David A. Williams
Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis
580(24)
Marc W. Harrold
Antithrombotics, Thrombolytics, Coagulants and Plasma Extenders
604(25)
Robert B. Palmer
Section 4 Drugs Affecting the Hormonal Systems 629(122)
Insulin and Oral Hypoglycemic Drugs
629(24)
Robert A. Wiley
Adrenocorticoids
653(32)
Duane D. Miller
Robert W. Brueggemeier
James T. Dalton
Estrogen, Progestins and Androgens
685(33)
Robert W. Brueggemeier
Duane D. Miller
James T. Dalton
Thyroid Function and Thyroid Drugs
718(21)
Ali R. Banijamali
Calcium Homeostasis
739(12)
Robin M. Zavod
Section 5 Drugs Affecting the Immune Systems 751(68)
Nonsteroidal Anti-Inflammatory Agents
751(43)
Ronald F. Borne
Antihistamines and Related Antiallergic and Antiulcer Agents
794(25)
Wendel L. Nelson
Section 6 Chemotherapeutic Agents 819(162)
Antibiotics and Antimicrobial Agents
819(48)
Lester A. Mitscher
Antiparasitic Agents
867(24)
Thomas L. Lemke
Antifungal Drugs
891(13)
Robert Griffith
Timothy Tracy
Antimycobacterial Agents
904(20)
Thomas L. Lemke
Cancer and Cancer Chemotherapy
924(28)
Patrick S. Callery
Peter M. Gannett
Antiviral Agents and Protease Inhibitors
952(29)
Manohar L. Sethi
Part III Recent Advances in Drug Discovery 981(89)
Pharmaceutical Biotechnology
982(34)
Robert D. Sindelar
Gene Therapy
1016(36)
Ronald E. Reid
Antisense Therapeutic Agents
1052(7)
Marilyn K. Speedie
Selective Estrogen Receptor Modulators
1059(11)
V. Craig Jordan
Appendices pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases pH Values for Tissue Fluids 1070
David A. Williams


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