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Foye's Principles of Medicinal Chemistry,9780781768795
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Foye's Principles of Medicinal Chemistry

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Lippincott Williams & Wilkins
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  • Foye's Principles of Medicinal Chemistry
    Foye's Principles of Medicinal Chemistry
  • Foye's Principles of Medicinal Chemistry
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  • Foye's Principles of Medicinal Chemistry
    Foye's Principles of Medicinal Chemistry


This comprehensive the Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. NEW TO THIS EDITION: Case studies from previous editions and answers to this edition's case studies will be available online at thePoint. New section on Disease State Management (Part IV) helps students understand how asthma, chronic obstructive pulmonary disease, and women's and men health issues can be treated with appropriate therapeutic options. 8-page color insert contains detailed illustrations of drug structures covered within the text. Clinical Significance boxes show students how the content in each of the chapters relates to effective pharmaceutical care. Drug Lists at the beginning of appropriate chapters are bulleted lists that provide students with a summary of the drugs covered within the chapter.

Table of Contents

Historical Perspective of Medicinal Chemistry Part I: Principles of Drug Discovery Chapter 1. Drug Discovery from Natural Products Chapter 2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity Chapter 3. Molecular Modeling and in Silico Chapter 4. Receptors and Drug Action Chapter 5. Drug Discovery Through Enzyme Inhibition Chapter 6. Pharmaceutical Biotechnology-From Nucleic Acids to Personalized Medicine Chapter 7. Peptide and Protein Drugs Chapter 8. Antisense Therapeutic Agents Chapter 9. Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics Chapter 10. Drug Metabolism Chapter 11. Drug Regulation: An Overview Part II: Drug Receptors Affecting Neurotransmission and Enzymes as Catalytic Receptors Overview of Drug Receptors: A Perspective Chapter 12. Drugs Affecting Cholinergic Neurotransmission Chapter 13. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission Chapter 14. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission Chapter 15. Amino Acid Neurotransmitters in the Central Nervous System Chapter 16. Inhibitors of Nerve Conduction: Local Anesthetics Chapter 17. Phosphodiesterase Inhibitors Part III: Pharmacodynamic Agents Section 1: Drugs Affecting Central Nervous System Chapter 18. General Anesthetics Chapter 19. Sedative-Hypnotics Chapter 20. Antiseizure Agents Chapter 21. Antidepressants Chapter 22. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents Chapter 23. Hallucinogens, Stimulants and Related Drugs of Abuse Chapter 24. Opioid Analgesics Chapter 25. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents Section 2: Drugs Affecting the Cardiovascular System Chapter 26. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs Chapter 27. Diuretics Chapter 28. Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers Chapter 29. Central and Peripheral Sympatholytics and Vasodilators Chapter 30. Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis Chapter 31. Antithrombotics, Thrombolytics, Coagulants, and Plasma Extenders Section 3: Drugs Affecting the Hormonal Systems Chapter 32. Insulin and Drugs Used for the Treatment of Diabetes Chapter 33. Adrenocorticoids Chapter 34. Thyroid Function and Thyroid Drugs Chapter 35. Calcium Homeostasis Section 4: Drugs Affecting the Immune Systems Chapter 36. Nonsteroidal Anti-Inflammatory Drugs Chapter 37. Antihistamines and Related Antiallergic and Antiulcer Agents Section 5: Chemotherapeutic Agents Chapter 38. Antibiotics and Antimicrobial Agents Chapter 39. Antiparasitic Agents Chapter 40. Antifungal Agents Chapter 41. Antimycobacterial Agents Chapter 42. Cancer and Chemotherapy Chapter 43. Antiviral Agents and Protease Inhibitors Part IV: Disease State Management Chapter 44. Asthma and Chronic Obstructive Pulmonary Disease Chapter 45. Men' Health Chapter 46. Women's Health Appendix A: pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases Appendix B: pH Values for Tissue Fluids

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