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9781420044331

Free Radicals in Ophthalmic Disorders

by ;
  • ISBN13:

    9781420044331

  • ISBN10:

    1420044338

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-03-24
  • Publisher: CRC Press

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Summary

Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splitting bond. After a free radical is formed they will continue to attack other molecules, which usually results in the damage of tissue or destruction of a healthy cell. Free radicals arise normally through metabolism, however sometimes the body's immune system will create them on purpose to neutralize viruses and bacteria. Free radicals are implicates in many ophthalmic disorders including uveitis, optic nerve damage, retinal ischemia, and macular degeneration. Free Radicals in Ophthalmic Disorders presents the most current knowledge pertaining to the role of free radicals/oxidants in ocular disorders, and the use of antioxidants in the prevention of these disordersWritten by today's leading ocular scientists and clinicians Free Radicals in Ophthalmic Disorders· Gives comprehensive coverage of the role of free radicals/oxidants in ocular disorders· Covers the use of antioxidants to prevent oxidative stress and ocular tissue damage· Examines external factors that may result in the stimulation and heightened occurrence of free radicals/oxidants· Is written by today's leading scientists and ophthalmologists

Table of Contents

Prefacep. iii
Contributorsp. vii
Free Radical Biology, Mitochondrial Functions, and Nitric Oxidep. 1
Antioxidants and Modulation of Cardiovascular Diseasep. 11
Nitric Oxide-Related Oxidants in Health and Diseasep. 33
Modulation and Determination of Cellular Glutathione Concentrationsp. 45
Oxidants in Corneal Diseasesp. 55
Involvement of Oxidative Stress in the Pathogenesis of Glaucomap. 71
Oxidative Stress and Cataractp. 81
Nitric Oxide in Experimental Autoimmune Uveoretinitisp. 107
TNF Activation and Nitric Oxide Production in EAUp. 121
Peroxynitrite and Ocular Inflammationp. 131
Melanin and Oxidative Reactionsp. 147
Are Antioxidants Useful in Diabetic Retinopathy?p. 159
Macular Degeneration: The Role of Reactive Oxygen Speciesp. 167
Retinal Ischemia and Oxidative Stressp. 177
Reduction of Oxidative Stress in Retinal Diseasep. 197
Indexp. 209
Table of Contents provided by Ingram. All Rights Reserved.

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