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How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks?
With its unique integration of genetics and molecular biology, Genetic Analysis explores these fascinating questions, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the genetic structure of natural populations follows, before the interaction of genes during suppression and epistasis, how we study gene networks, and personalized genomics are considered.
Drawing on the latest experimental tools, including microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader to the forefront of contemporary research with exceptional clarity.
We are in an age where, despite knowing so much about biological systems, we are just beginning to realize how much more there is still to understand. Genetic Analysis is the ideal guide to harnessing the awesome power of molecular genetics to further our understanding of biology.
Philip Meneely is Professor of Biology in the Department of Biology at Haverford College, PA, where he teaches genetics, molecular biology, and bioinformatics.
Table of Contents
Unit I Genes, Chromosomes, and Genomes 1. The Logic of Genetic Analysis 2. Model Organisms and Their Genomes 3. Genomes, Chromosomes, and Epigenetics Unit II Genes and Mutations 4. Identifying and Classifying Mutants 5. Connecting a Phenotype to a DNA Sequence 6. Finding Mutant Phenotypes for Cloned Genes 7. Genome-wide Mutant Screens Unit III Genes and Natural Variation 8. Genome-wide Associations 9. Genetic Analysis of Complex Traits 10. Genetic Analysis Using Natural Variation Unit IV Gene Interactions 11. Using One Gene to Identify Functionally Related Genes 12. Epistasis and Genetic Pathways 13. Pathways, Networks, and Systems 14. Genes, Systems, and Phenotypes