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Genetics : From Genes to Genomes,9780073227382
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Genetics : From Genes to Genomes

by ; ; ; ;
Edition:
3rd
ISBN13:

9780073227382

ISBN10:
0073227382
Format:
Hardcover
Pub. Date:
10/9/2006
Publisher(s):
McGraw-Hill Science/Engineering/Math
List Price: $203.45
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Summary

Genetics: From Genes to Genomesis a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Third Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.

Table of Contents

About the Authors iii
Preface xi
Acknowledgements xxi
Genetics: The Study of Biological Information
1(12)
The Biological Information Fundamental to Life is Encoded in the DNA Molecule
1(2)
Biological Function Emerges Primarily from Protein Molecules
3(1)
Complex Systems Arise from DNA-Protein and Protein-Protein Interactions
4(1)
All Living Things Are Closely Related at the Molecular Level
5(2)
The Modular Construction of Genomes Has Allowed the Rapid Evolution of Complexity
7(1)
Genetic Techniques Permit the Dissection of Complexity
8(2)
Our Focus Is on Human Genetics
10(3)
PART I Basic Principles: How Traits Are Transmitted
13(154)
Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity
13(32)
Background: The Historical Puzzle of Inheritance
15(4)
Genetic Analysis According to Mendel
19(11)
Mendelian Inheritance in Humans: Two Comprehensive Examples
30(15)
Fast Forward
22(6)
Tools of Genetics
28(6)
Genetics and Society
34(11)
Extensions to Mendel: Complexities in Relating Genotype to Phenotype
45(36)
Extensions to Mendel for Single-Gene Inheritance
46(10)
Extensions to Mendel for Multifactorial Inheritance
56(25)
Fast Forward
57(11)
Genetics and Society
68(13)
The Chromosome Theory of Inheritance
81(42)
Chromosomes Contain the Genetic Material
82(6)
Mitosis Ensures That Every Cell in an Organism Carries the Same Chromosomes
88(5)
Meiosis Produces Haploid Germ Cells, the Gametes
93(10)
Gametogenesis Requires Both Mitotic and Meiotic Divisions
103(2)
Validation of the Chromosome Theory
105(18)
Genetics and Society
87(8)
Fast Forward
95(28)
Linkage, Recombination, and the Mapping of Genes on Chromosomes
123(44)
Gene Linkage and Recombination
124(11)
Mapping: Locating Genes Along a Chromosome
135(17)
Mitotic Recombination Can Produce Genetic Mosaics
152(15)
Tools of Genetics
128(14)
Fast Forward
142(12)
Genetics and Society
154(13)
PART II What Genes Are and What They Do
167(134)
DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information
167(40)
Experiments Designate DNA as the Genetic Material
168(5)
The Watson-Crick Model: DNA Is a Double Helix
173(7)
DNA Stores Information in the Sequence of Its Bases
180(4)
DNA Replication: Copying Genetic Information for Transmission to the Next Generation
184(7)
Recombination Reshuffles the Information Content of DNA
191(16)
Tools of Genetics
182(25)
Anatomy and Function of a Gene: Dissection Through Mutation
207(48)
Mutations: Primary Tools of Genetic Analysis
208(16)
What Mutations Tell Us About Gene Structure
224(8)
What Mutations Tell Us About Gene Function
232(7)
How Gene Mutations Affect Light-Receiving Proteins and Vision: A Comprehensive Example
239(16)
Genetics and Society
216(24)
Fast Forward
240(15)
Gene Expression: The Flow of Genetic Information from DNA to RNA to Protein
255(46)
The Genetic Code: How Precise Groupings of the Four Nucleotides Specify 20 Amino Acids
257(8)
Transcription: RNA Polymerase Synthesizes a Single-Stranded RNA Copy of a Gene
265(10)
Translation: Base Pairing Between mRNA and tRNAs Directs Assembly of a Polypeptide on the Ribosome
275(7)
There Are Significant Differences in Gene Expression Between Prokaryotes and Eukaryotes
282(2)
Comprehensive Example: A Computerized Analysis of Gene Expression in C. elegans
284(1)
How Mutations Affect Gene Expression and Gene Function
285(16)
Genetics and Society
270(31)
PART III Genomes
301(164)
Deconstructing the Genome: DNA at High Resolution
301(50)
Fragmenting Complex Genomes into Bite-Size Pieces for Analysis
303(7)
Cloning Fragments of DNA
310(9)
Hybridization Is Used to Identify Similar DNA Sequences
319(8)
The Polymerase Chain Reaction Provides a Rapid Method for Isolating DNA Fragments
327(3)
DNA Sequence Analysis
330(5)
Understanding the Genes for Hemoglobin: A Comprehensive Example
335(16)
Tools of Genetics
306(14)
Genetics and Society
320(31)
Reconstructing the Genome Through Genetic and Molecular Analysis
351(40)
Analyses of Genomes
354(12)
Major Insights from the Human and Model Organism Genome Sequences
366(9)
High-Throughput Genomic Platforms Permit the Global Analysis of Genes and Their mRNAs
375(16)
Genetics and Society
381(10)
The Direct Detection of Genotype Distinguishes Individual Genomes
391(46)
DNA Variation Is Multifaceted and Widespread
394(5)
Detecting DNA Genotypes of Different Types of Polymorphisms
399(9)
Positional Cloning: From DNA Markers to Gene Clones
408(11)
Genetic Dissection of Complex Traits
419(4)
Haplotype Association Studies for High-Resolution Mapping in Humans
423(14)
Genetics and Society
394(22)
Tools of Genetics
416(21)
Systems Biology and Proteomics
437(28)
What Is Systems Biology?
439(1)
Looking at Biology as an Informational Science Is Central to the Practice of Systems Biology
440(4)
Global Proteomics Strategies and High-Throughput Platforms Make It Possible to Gather and Analyze Systemwide Protein Data
444(7)
Putting It All Together: The Practice of Systems Biology
451(4)
A Systems Approach to Disease Leads to Predictive, Preventive, and Personalized Medicine
455(10)
Genetics and Society
457(8)
PART IV How Genes Travel on Chromosomes
465(144)
The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA
465(24)
The Components of Eukaryotic Chromosomes: DNA, Histones, and Nonhistone Proteins
466(3)
Chromosome Structure: Variable DNA-Protein Interactions Create Reversible Levels of Compaction
469(5)
Specialized Chromosomal Elements Ensure Accurate Replication and Segregation of Chromosomes
474(5)
How Chromosomal Packaging Influences Gene Activity
479(10)
Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes
489(50)
Rearrangements of DNA Sequences Within Chromosomes
491(25)
Changes in Chromosome Number
516(8)
A Glimpse of the Future: Emergent Technologies in the Analysis of Chromosomal Rearrangements and Changes in Chromosome Number
524(15)
Fast Forward
492(47)
The Prokaryotic Chromosome: Genetic Analysis in Bacteria
539(42)
A General Overview of Prokaryotes
540(3)
The Bacterial Genome
543(7)
Gene Transfer in Bacteria
550(16)
Comprehensive Example: Genetic Dissection Helps Explain How Bacteria Move
566(4)
Genome Analysis Provides Powerful New Tools for Understanding Bacteria
570(11)
Genetics and Society
544(37)
The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of Inheritance
581(28)
The Structure and Function of Mitochondrial and Chloroplast Genomes
583(9)
Genetic Studies of Organelle Genomes Clarify Key Elements of Non-Mendelian Inheritance
592(7)
Comprehensive Example: How Mutations in mtDNA Affect Human Health
599(10)
Fast Forward
594(6)
Genetics and Society
600(9)
PART V How Genes Are Regulated
609(148)
Gene Regulation in Prokaryotes
609(34)
An Overview of Prokaryotic Gene Regulation
611(1)
The Regulation of Gene Transcription
612(14)
The Attenuation of Gene Expression: Fine-Tuning the trp Operon Through the Termination of Transcription
626(2)
Global Regulatory Mechanisms Coordinate the Expression of Many Sets of Genes
628(4)
A Comprehensive Example: The Regulation of Virulence Genes in V. cholerae
632(11)
Genetics and Society
630(13)
Gene Regulation in Eukaryotes
643(42)
The Use of Genetics to Study Gene Regulation
645(1)
Gene Regulation Begins with Control Over the Initiation of Transcription
646(18)
Regulation After Transcription Influences RNA Production, Protein Synthesis, and Protein Stability
664(5)
Sex Determination in Drosophila: A Comprehensive Example of Gene Regulation
669(16)
Tools of Genetics
670(15)
Cell-Cycle Regulation and the Genetics of Cancer
685(32)
The Normal Control of Cell Division
686(10)
Cancer Arises When Controls Over Cell Division No Longer Function Properly
696(21)
Using Genetics to Study Development
717(40)
Model Organisms: Prototypes for Developmental Genetics
719(2)
Genetics Simplifies the Study of Development
721(11)
The Genetic Analysis of Body-Plan Development in Drosophila: A Comprehensive Example
732(13)
How Genes Help Control Development: A Mechanistic Framework
745(12)
Genetics and Society
724(33)
PART VI How Genes Change
757
The Genetic Analysis of Populations and How They Evolve
757(34)
The Hardy-Weinberg Law: A Model for Understanding Allele, Genotype, and Phenotype Frequencies for a Single-Gene Trait in a Genetically Stable Population
759(3)
Beyond Hardy-Weinberg: Measuring How Mutation and Selection Cause Changes in Allele Frequencies
762(11)
Analyzing the Quantitative Variation of Multifactorial Traits
773(18)
Genetics and Society
780(11)
Evolution at the Molecular Level
791
The Origin of Life on Earth
794(5)
The Evolution of Genomes
799(6)
The Organization of Genomes
805(8)
The Immunoglobulin Gene Superfamily: A Comprehensive Example of Molecular Evolution
813
Genetics and Society
802
Guidelines for Gene Nomenclature 1(1)
Brief Answer Section 1(1)
Glossary 1(1)
Credits 1(1)
Index 1


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