Guide to Genital HPV Diseases and Prevention

by Bonnez; William

• ISBN13: 9781439808993
• ISBN10: 1439808996
• Edition: 1st
• Format: Nonspecific Binding
• Copyright: 2009-04-14
• Publisher: CRC Press

Summary

Key features of this must-have guide: COMPREHENSIVE COVERAGE-exploring the background, diagnosis, screening, prevention, and treatment of HPV, physicians have the knowledge they need to educate, diagnose, and treat patients with this disease DETAILED PREVENTION STRATEGIES-focusing on recent vaccine discoveries, both approved and in development, help control the outspread of HPV LATEST TREATMENT OPTIONS-including both chemical and physical methods, helps avoid related complications and optimize patient outcomes EXPERT EDITORSHIP-edited by one of the discoverers of the HPV vaccine, this is reliable, first-hand guidance that all professionals need to stay at the forefront of HPV

Table of Contents

Preface

Overview

Biology

Basic Virology

Structure

Classification and Disease Association

Genome Organization

Viral Proteins

Growth in Cell Cultures and Animal Models

Antigenicity

Pathogenesis

Molecular and Cellular Pathogenesis

Active Infection

Oncogenesis

Latency

Immunology

Humoral Response

Cellular Innate and Adaptative Response

References

Epidemiology

Incidence and Prevalence

Risk Factors

HPV and Cancer, the Casual Link

Transmission and Reinfection

Natural History

References

HPV Diseases

External Anogenital Warts

Other Diseases of the Anogenital Tract

Diseases of the Head and Neck Area

References

Treatment

The Armamentarium

Chemical Methods

Physical Methods

Approach to Treatment

External Anogenital Warts

Other Diseases of the Anogenital Tract

Diseases of the Head and Neck Area

References

Diagnosis

Cytology and Colposcopy

Histology

Nucleic Acid Detection Methods

Serology

References

Screening

Screening Strategies

Appropriate Use of HPV DNA Testing

New Screnning Markers

References

Prevention

Condoms and Microbicides

Vaccination

Vaccine Preclinical and Early Clinical Development

Gardasil/Silgard

Clinical Trials

Phase I Studies

Phase II Studies

Phase III and IV Studies

The Vaccine

Vaccine Recommendations

Availability

Duration of Immunity

Contraindications

Adverse Events

Cervarix

Clinical Trials

Phase I Studies

Phase II Studies

Phase III and IV Studies

The Vaccine

Vaccine Recommendations

Availability

Duration of Immunity

Contraindications

Adverse Events

Other Vaccines in Development

Benefits, Obstacles, and Strategies to Implement HPV Vaccination

Unanswered Questions

References.

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