Hereditary Tumors : From Genes to Clinical Consequences

by Editor: Heike Allgayer (Universitat Heidelberg, Experimentelle Chirurgie, Universitatsklinikum Mannheim); Editor: Helga Rehder (Medizinische Universitat Wien, Austria); Editor: Simone Fulda (University Children's Hospital, Ulm, Germany)

• ISBN13: 9783527320288
• ISBN10: 3527320288
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-03-01
• Publisher: Blackwell Pub

Summary

Summarizing molecular aspects, diagnostic as well as therapeutic issues, this book is the very first and most comprehensive on hereditary aspects of tumor diseases. All the contributors have been made fellows of the Ingrid zu Solms Foundation due to their outstanding achievements in scientific research, and they discuss here the latest aspects in the diagnosis, disease management, and treatment of hereditary tumor diseases and syndromes. A must-have ready reference for medical and biology students, MDs, PhDs, physicians, and researchers.

Author Biography

Heike Allgayer is the Department Head of Experimental Surgery at the Mannheim Medical Faculty of University of Heidelberg, and also Head of the Molecular Oncology of Solid Tumor's Unit at German Cancer Research Center (DKFZ), Heidelberg. Her major research interests include tumor progression, invasion and metastasis, molecular determinants of carcinogenesis and cancer progression, translational research, and molecular staging of cancer. She has authored 145 scientific publications and has received 19 scientific awards.

Helga Rehder, MD, PhD, former head of the Institute of Clinical Genetics of the Philipps-University Marburg, is now Guest Professor of the Department of Medical Genetics at University Vienna. As a Pathologist and Human Geneticist, her fields of research activities were 'Fetal Pathology and Syndromology' and 'Tumor Genetics'. Her publication list covers 138 papers and she has received four awards, including the Hans Nachtsheim-Award of the Society of Human Genetics and the Jacob Henle-Medal' of the University G+¦ttingen. Helga Rehder is member of the Curatory of the Ingrid-zu-Solms-Foundation, and head of the Consultive Committee for the Ingrid zu Solms-Award for Woman-Scientists.

Simone Fulda is Full Professor of Pediatric Research and Head of the Clinical Research Group on Apoptosis at Ulm University, Germany. She trained as pediatric oncologist and molecular/cell biologist in Germany, Harvard Medical School Boston, San Francisco, Phoenix and in the UK. Her research focusses on elucidating apoptosis signaling pathways in cancer and during cancer therapy. She holds several international patent applications and has received various scientific awards, including the Schweizgurth Prize of the International Society of Pediatric Oncology, the Kind-Philipp-Prize of the German Society of Pediatric Oncology & Hematology, the Vincenz-Czerny Preis of the German Society of Hematology & Oncology, the Research Award of the Ingrid zu Solms-Foundation, Merckle Research Award, Johann-Georg-Zimmermann Award and the Heisenberg excellence grant of the German Science Foundation. She is member of several international advisory boards, editorial board member of Cancer Research and Recent Patents on Anti-Cancer Drug Discovery and Editor of "Apoptosis and Cancer Therapy" published by Wiley-VCH.

Table of Contents

Hereditary Tumors-General Aspects

Tumor Invasion, Progression and Metastasis

The Genetic Background of Hereditary Tumor Diseases

Syndromal Types Of Hereditary Tumors

Family Cancer Syndromes

Genetic Dysmorphic Syndromes Leading to Tumorigenesis

Site-Specific Hereditary Tumors

Hereditary Brain Tumors

Neurofibromatosis

Retinoblastoma: The Prototypic Hereditary Tumor (

Hereditary Cancer in the Head and Neck

Hereditary Medullary and Familial Nonmedullary Thyroid Carcinoma

Lung Tumors (Danson, Teare, Woll) Hereditary Breast Cancer

The Hereditary Ovarian and Endometrial Cancer

Prostate Cancer

Wilms and Rhabdoid Tumors of the Kidney

Hereditary Renal Tumours of the Adult

Gastrointestinal Polyposis Syndromes

Lynch Syndrome (HNPCC)

Gastrointestinal Stromal Tumors (GISTs)

Hereditary Gastric Cancer

Pancreatic Cancer

Liver Tumors

DNA-Repair Deficiency and Cancer

Lessons from Lymphoma

Leukemia (Fonatsch) Malignant MelanomaBerking, Bosserhoff

Xeroderma Pigmentosum, Cockayne Syndrome, Trichothiodystrophy - Defects in DNA Repair and Carcinogenesis

Hereditary Tumors in Children

Sarcomas and Bone Tumors in Adulthood

Genetic Counselling; Psychooncology; And General Perspectives For Therapeutic Strategies

Genetic Counselling for Hereditary Tumors

Psychooncologic Aspects of Hereditary Tumors and Predictive Testing

Molecular Targeted Therapy

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