Preface | p. vii |
Prefertilization Events | p. 1 |
Gametes (Oocytes and Spermatozoa) | p. 1 |
Meiosis | p. 1 |
Female Gametogenesis (Oogenesis) | p. 1 |
Hormonal Control of the Female Reproductive Cycle | p. 3 |
Male Gametogenesis (Spermatogenesis) | p. 4 |
Clinical Considerations | p. 4 |
Week 1 (Days 1-7) | p. 7 |
Overview | p. 7 |
Fertilization | p. 7 |
Cleavage | p. 7 |
Blastocyst Formation | p. 8 |
Implantation | p. 8 |
Clinical Considerations | p. 9 |
Week 2 (Days 8-14) | p. 12 |
Embryoblast | p. 12 |
Trophoblast | p. 12 |
Extraembryonic Mesoderm | p. 12 |
Clinical Considerations | p. 13 |
Embryonic Period (Weeks 3-8) | p. 17 |
Introduction | p. 17 |
Gastrulation | p. 17 |
Clinical Considerations | p. 17 |
Placenta, Amniotic Fluid, and Umbilical Cord | p. 22 |
Placenta | p. 22 |
The Placenta as an Endocrine Organ | p. 23 |
The Placental Membrane | p. 24 |
Amniotic Fluid | p. 26 |
Umbilical Cord | p. 27 |
Vasculogenesis | p. 27 |
Hematopoiesis | p. 28 |
Fetal Circulation | p. 29 |
Cardiovascular System | p. 32 |
Formation of Heart Tube | p. 32 |
Primitive Heart Tube Dilatations | p. 32 |
The Aorticopulmonary (AP) Septum | p. 33 |
The Atrial Septum | p. 35 |
The Atrioventricular (AV) Septum | p. 37 |
The Interventricular (IV) Septum | p. 39 |
Development of the Arterial System | p. 40 |
Development of the Venous System | p. 40 |
Digestive System | p. 43 |
Primitive Gut Tube | p. 43 |
Foregut Derivatives | p. 44 |
Midgut Derivatives | p. 49 |
Hindgut Derivatives | p. 52 |
The Anal Canal | p. 54 |
Mesenteries | p. 55 |
Urinary System | p. 58 |
Overview | p. 58 |
The Pronephros | p. 58 |
The Mesonephros | p. 58 |
The Metanephros | p. 58 |
Development of the Metanephros | p. 59 |
Relative Ascent of the Kidneys | p. 61 |
Blood Supply of the Kidneys | p. 61 |
Development of the Urinary Bladder | p. 61 |
Clinical Considerations | p. 61 |
Female Reproductive System | p. 66 |
The Indifferent Embryo | p. 66 |
Development of the Gonads | p. 66 |
Development of Genital Ducts | p. 67 |
Development of the Primordia of External Genitalia | p. 67 |
Clinical Considerations | p. 70 |
Male Reproductive System | p. 73 |
The Indifferent Embryo | p. 73 |
Development of the Gonads | p. 73 |
Development of the Genital Ducts | p. 74 |
Development of the Primordia of External Genitalia | p. 74 |
Clinical Considerations | p. 76 |
Summary Table of Female and Male Reproductive Systems Development | p. 81 |
Respiratory System | p. 83 |
Upper Respiratory System | p. 83 |
Lower Respiratory System | p. 83 |
Development of the Trachea | p. 83 |
Development of the Bronchi | p. 85 |
Development of the Lungs | p. 86 |
Head and Neck | p. 90 |
Pharyngeal Apparatus | p. 90 |
Development of the Thyroid Gland | p. 90 |
Development of the Tongue | p. 93 |
Development of the Face | p. 94 |
Development of the Palate | p. 94 |
Clinical Considerations | p. 95 |
Nervous System | p. 100 |
Development of the Neural Tube | p. 100 |
Neural Crest Cells | p. 100 |
Vesicle Development of the Neural Tube | p. 102 |
Development of the Spinal Cord | p. 104 |
Development of the Hypophysis (Pituitary Gland) | p. 105 |
Congenital Malformations of the Central Nervous System | p. 106 |
Ear | p. 111 |
Overview | p. 111 |
The Internal Ear | p. 111 |
The Membranous and Bony Labyrinths | p. 113 |
The Middle Ear | p. 113 |
The External Ear | p. 113 |
Congenital Malformations of the Ear | p. 114 |
Eye | p. 117 |
Development of the Optic Vesicle | p. 117 |
Development of Other Eye Structures | p. 119 |
Congenital Malformations of the Eye | p. 120 |
Body Cavities | p. 124 |
Formation of the Intraembryonic Coelom | p. 124 |
Partitioning of the Intraembryonic Coelom | p. 124 |
Positional Changes of the Diaphragm | p. 125 |
Clinical Considerations | p. 126 |
Pregnancy | p. 128 |
Endocrinology of Pregnancy | p. 128 |
Pregnancy Dating | p. 129 |
Pregnancy Milestones | p. 130 |
Prenatal Diagnostic Procedures | p. 131 |
Fetal Distress During Labor (Intrapartum) | p. 132 |
The Apgar Score | p. 132 |
Puerperium | p. 133 |
Lactation | p. 133 |
Teratology | p. 134 |
Introduction | p. 134 |
Infectious Agents | p. 134 |
TORCH Infections | p. 137 |
Category X Drugs (Absolute Contraindication in Pregnancy) | p. 137 |
Category D Drugs (Definite Evidence of Risk to Fetus) | p. 138 |
Chemical Agents | p. 139 |
Recreational Drugs | p. 140 |
Ionizing Radiation | p. 140 |
Selected Photographs | p. 140 |
Credits | p. 142 |
Index | p. 147 |
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