Human Hypothalamus in Health and Disease : Proceedings of the 17th International Summer School of Brain Research, Held at the Auditorium of the University of Amsterdam, the Netherlands, 26-30 August 1991

by Swaab

• ISBN13: 9780444895387
• ISBN10: 0444895388
• Format: Hardcover
• Copyright: 1992-05-01
• Publisher: Elsevier Science Ltd

Summary

This volume is based on the first international multidisciplinary conference on the human hypothalamus in health and disease, where international experts shared current knowledge. The involvement of the hypothalamus in human development, and alterations in hypothalamic structures connected to human diseases are areas which have only recently been published in scientific literature. Such data provides unique information on possible functions of the different hypothalamic nuclei. With the advent of powerful molecular, physiological, neuroanatomical and morphometric techniques, more questions and answers will be generated. Already different groups from various disciplines in many countries work on different aspects of the human hypothalamus and its workings, providing new and exciting data. This volume integrates this new information in the form of review chapters for students, researchers and clinicians. In addition, the book will initiate further interdisciplinary international colloborative research efforts in this field.

Table of Contents

List of Contributors
Preface
Acknowledgements
Structure of the Human Hypothalamus
Anatomy of the human hypothalamus (chiasmatic and tuberal region)	p. 3
Clinical Manifestations of Hypothalamic Diseases
Endocrine functions of the hypothalamus and alterations in neuroendocrine function - focus on thyrotropin and growth hormone	p. 19
Neurologic manifestations of hypothalamic disease	p. 31
Technical Potentialities and Pitfalls in the Use of Human Material
In situ hybridization histochemistry in the human hypothalamus	p. 45
Receptor localization in the human hypothalamus	p. 57
Human hypothalamic and pituitary neuroendocrine function during in vitro perifusion	p. 69
Brain banking and the human hypothalamus - factors to match for, pitfalls and potentials	p. 83
Biological Rhythms
The fourth C.U. Ariens Kappers lecture	p. 99
The organization of the human circadian timing system	p. 101
Prenatal development of a hypothalamic biological clock	p. 119
The human hypothalamus: comparative morphometry and photoperiodic influences	p. 133
Circadian rhythms and the suprachiasmatic nucleus in perinatal development, aging and Alzheimer's disease	p. 151
Development, Aging and Dementia
Ontogeny of peptides in the human hypothalamus in relation to sudden infant death syndrome (SIDS)	p. 167
LHRH neurons: functions and development	p. 189
The human hypothalamus in relation to gender and sexual orientation	p. 205
Hormonal influences on morphology and neuropeptide gene expression in the infundibular nucleus of post-menopausal women	p. 221
The human hypothalamo-neurohypophyseal system in relation to development, aging and Alzheimer's disease	p. 237
The hypothalamic lateral tuberal nucleus: normal anatomy and changes in neurological diseases	p. 249
Galanin tuberomammillary neurons in the hypothalamus in Alzheimer's and Parkinson's diseases	p. 263
Osmoregulation
Animal models for osmoregulatory disturbances	p. 273
Autoimmune hypothalamic diabetes insipidus ("autoimmune hypothalamitis")	p. 283
The molecular biology of human hereditary central diabetes insipidus	p. 295
The use of linkage analysis and the Centre d'Etude Polymorphisme Humain (CEPH) panel of DNA in the study of the arginine vasopressin, oxytocin and prodynorphin gene loci	p. 309
Hypothalamus and Reproduction
Animal models for brain and pituitary gonadal disturbances	p. 321
Genetic, hypothalamic and endocrine features of clinical and experimental obesity	p. 333
Hypothalamic involvement in sexuality and hostility: comparative psychological aspects	p. 343
Hypothalamus and Stress
Re-examination of the glucocorticoid hypothesis of stress and aging	p. 365
The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia	p. 385
Endogenous pyrogens in the CNS: role in the febrile response	p. 419
Psychiatric Diseases
Endorphins and schizophrenia	p. 433
Neurohypophyseal peptides and psychopathology	p. 455
Subject Index	p. 463
Table of Contents provided by Blackwell. All Rights Reserved.