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Human Population Genetics



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Human Population Genetics will provide an introduction to mathematical population genetics, along with relevant examples from human (and some non-human primate) populations, and will also present concepts and methods of population genetics that are specific to the study of human populations. The purpose of this book is to provide a basic background text for advanced undergraduate and graduate students interesting in the mechanisms of human microevolution.

Table of Contents

Forewordp. vii
Prefacep. ix
Genetic, Mathematical, and Anthropological Backgroundp. 1
The Scope of Population Geneticsp. 2
Genetics Backgroundp. 5
Principles of Probabilityp. 14
The Anthropological Connectionp. 17
A Closing Thoughtp. 21
Hardy-Weinberg Equilibriump. 23
Genotype and Allele Frequenciesp. 24
What is Hardy-Weinberg Equilibrium?p. 30
The Mathematics of Hardy-Weinberg Equilibriump. 31
Using Hardy-Weinberg Equilibriump. 37
Extensions of Hardy-Weinberg Equilibriump. 40
Hardy-Weinberg Equilibrium and Evolutionp. 44
Summaryp. 45
Inbreedingp. 49
Quantifying Inbreedingp. 51
Population Genetics and Inbreedingp. 62
Inbreeding in Human Populationsp. 65
Summaryp. 75
Mutationp. 77
The Nature of Mutationsp. 77
Models of Mutationp. 81
Mutational History and Anthropological Questionsp. 88
Summaryp. 96
Genetic Driftp. 101
What is Genetic Drift?p. 102
Genetic Drift and Population Sizep. 112
Effects on Genetic Variationp. 120
Mutation and Genetic Driftp. 121
Coalescent Theoryp. 125
Summaryp. 131
Models of Natural Selectionp. 139
How Does Natural Selection Work?p. 140
A General Model of Natural Selectionp. 145
Types of Natural Selectionp. 147
Other Aspects of Selectionp. 160
Summaryp. 167
Natural Selection in Human Populationsp. 181
Case Studies of Natural Selection in Human Populationsp. 182
Are Humans Still Evolving?p. 198
Summaryp. 203
Gene Flowp. 205
The Evolutionary Impact of Gene Flowp. 206
Models of Gene Flowp. 208
Gene Flow and Genetic Driftp. 213
Estimating Admixture in Human Populationsp. 226
Summaryp. 230
Human Population Structure and Historyp. 237
Case Studies of Human Population Structurep. 238
The Origin of Modern Humansp. 242
Case Studies of Population Originsp. 247
Summaryp. 255
Glossaryp. 257
Referencesp. 267
Indexp. 279
Table of Contents provided by Ingram. All Rights Reserved.

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