Infection and Immunity

by Playfair, John H. L.; Bancroft, Gregory J.

• ISBN13: 9780199264957
• ISBN10: 0199264953
• Edition: 2nd
• Format: Paperback
• Copyright: 2004-05-20
• Publisher: Oxford University Press

Summary

The second edition of Infection and Immunity explains how, in the lucid, accessible style for which John Playfair is well known, and with extensive new input from Gregory Bancroft, an expert in infectious diseases. The authors describe the main causes of infection -- from viruses to worms -- and explain the intricate ways in which the body responds to infection, from detection of potentially dangerous organisms, to their ultimate elimination and how this can fail. With examples of infectious diseases from across the world, and with vastly expanded coverage compared to the first edition, the second edition of Infection and Immunity is the perfect resource for biomedical science, bioscience, microbiology, and epidemiology students who need to understand what causes infection, and how our immune systems respond. Book jacket.

Author Biography

Professor John Playfair is a widely known and well-respected academic and teacher in the field of immunology, having established the immunology course at University College London Medical Hospital where he was chairman of the Department of Immunology. His talent as an educator is reflected in the numerous other textbook projects with which he has been involved including Mim's Medical Microbiology 2e (Mosby), and Immunology at a glance 7e (Blackwell). Dr. Greg Bancroft is Reader in Immunology at the London School of Hygiene and Tropical Medicine where he established, and still teaches on, the MSc Immunology of Infectious Diseases course, an area of expertise that has been invaluable in the preparation of this second edition.

Table of Contents

List of abbreviations	xiii
Part 1 The infectious organisms
Introduction: parasites, pathogens, and immunity	3	(8)
Viruses	11	(8)
Bacteria	19	(8)
Fungi	27	(4)
Protozoa	31	(8)
Helminths (worms)	39	(8)
Prions	47	(2)
Disease: virulence and susceptibility	49	(12)
Tutorial 1	57	(4)
Part 2 The immune system
External defences: entry and exit	61	(8)
The immune system: introduction	69	(8)
Innate immunity	77	(18)
How pathogens escape innate immunity	95	(6)
Disease due to innate immunity	101	(6)
Immunodeficiency I: primary defects of innate immunity	107	(10)
Tutorial 2	113	(4)
Adaptive immunity: introduction	117	(8)
B cells and antibody	125	(10)
T cells and the MHC	135	(12)
The antibody response	147	(10)
Cell-mediated responses	157	(10)
Regulation of immune responses and memory	167	(8)
How pathogens escape adaptive immunity	175	(10)
Disease due to adaptive immunity I: hypersensitivity	185	(8)
Disease due to adaptive immunity II: autoimmunity	193	(8)
Immunodeficiency II: primary defects of adaptive immunity	201	(6)
Immunodeficiency III: secondary immunodeficiency and AIDS	207	(16)
Tutorial 3	217	(6)
Part 3 The host-pathogen balance
Epidemiology	223	(8)
Control of infectious disease: vaccination	231	(12)
Control of infectious disease: chemotherapy	243	(8)
Control of infectious disease: public health measures	251	(4)
Viral and prion disease and immunity	255	(6)
Bacterial disease and immunity	261	(10)
Fungal disease and immunity	271	(4)
Protozoal disease and immunity	275	(6)
Helminth disease and immunity	281	(4)
Emerging and future infectious diseases	285	(10)
Tutorial 4	291	(4)
Appendix 1. The major pathogens of man	295	(2)
Appendix 2. Cytokines	297	(2)
Appendix 3. CD molecules	299	(2)
Further reading	301	(6)
Index	307