9780521104746

Inherited Susceptibility to Cancer: Clinical, Predictive and Ethical Perspectives

by
  • ISBN13:

    9780521104746

  • ISBN10:

    0521104742

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2009-03-19
  • Publisher: Cambridge University Press
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Summary

Many cancers, both common and rare, are known to have a hereditary predisposition. Recent advances in genomics have clarified the risks, and in some cases the mechanisms, of cancer developing in an individual. This volume covers all the key issues in cancer genetics, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. The first of two parts deals with ethical, legal, and social issues, with chapters on counseling, screening, and gene and mutation identification. The second part systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. With a final chapter highlighting late-breaking developments, this up-to-date and authoritative volume will be of great interest to the specialist as well as other professionals in the areas of primary care, counseling, and cancer risk assessment.

Table of Contents

Ethical, legal and social issues, screening, counselling, gene and mutation detection
The inherited basis of cancer
Screening for cancer in those at high risk as a result of genetic susceptibility
Ethical and legal perspectives on inherited cancer susceptibility
Cancer genetics and public expectations
Genetic counselling
Cancer genetics in primary care
Genetic epidemiologic approaches to finding genes that influence susceptibility to cancer
Mutation detection
Hereditary contribution to cancer: site-by-site and special groups
Cancers of the digestive system
Cancers of the breast, ovary and uterus
Cancers of the kidney and urothelium
Cancers of the prostate and testes Steven Narod
The neurofibromatoses and other neuro-oncological syndromes
Malignant melanoma
Non-melanoma skin cancer
Endocrine cancers
Tobacco-related cancers of the respiratory and upper digestive tract
Inherited abnormalities of DNA processing and predisposition to cancer
Childhood cancer
Late-breaking developments
Index
Table of Contents provided by Publisher. All Rights Reserved.

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