Intracellular Delivery

by Prokop, Ales

• ISBN13: 9789400712478
• ISBN10: 9400712472
• Format: Hardcover
• Copyright: 2011-06-28
• Publisher: Springer Verlag

Summary

This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.

Table of Contents

Mechanisms of Uptake and Targeting
Mass Transport via Cellular Barriers and Endocytosis	p. 3
Approaches to Achieving Sub-cellular Targeting of Bioactives Using Pharmaceutical Nanocarriers	p. 57
Delivery to Intracellular Targets by Nanosized Particles	p. 73
The Potential and Current Progress of Internalizing Molecules in Targeted Drug Delivery	p. 97
Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool	p. 125
Nanosized Drug Delivery Vectors and the Reticuloendothelial System	p. 155
Membrane Crossover by Cell-Penetrating Peptides: Kinetics and Mechanisms - From Model to Cell Membrane Perturbation by Permeant Peptides	p. 179
Nanocarrier Formulation
Intracellular Delivery: A Multifunctional and Modular Approach	p. 199
Poly(Alkyl Cyanoacrylate) Nanosystems	p. 225
Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery	p. 251
Stimuli-Responsive Polymersomes	p. 291
Silica-Based Nanoparticles for Intracellular Drug Delivery	p. 333
Magnetic Nanoparticles for Biomedicine	p. 363
Biosynthesis of Metallic Nanoparticles and Their Applications	p. 373
Nanocrystals: Production, Cellular Drug Delivery, Current and Future Products	p. 411
Processing and Scale-up of Polymeric Nanoparticles	p. 433
Medical Applications
Magnetic Resonance Tracking of Stem Cells with Iron Oxide Particles	p. 459
Nanoparticles for the Oral Administration of Cancer Therapies	p. 487
Nanoparticles for Photodynamic Therapy Applications	p. 511
Nanoparticles Enhanced Hyperthermia	p. 567
Non-viral Gene Therapy	p. 599
Imaging of Nanoparticle Delivery Using Terahertz Waves	p. 701
Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging	p. 713
Intracellular Bacteria and Protozoa	p. 745
Gene Therapy in Bone Regeneration: A Summary of Delivery Approaches for Effective Therapies	p. 813
Nanoinformatics: Developing Advanced Informatics Applications for Nanomedicine	p. 847
Index	p. 861
Table of Contents provided by Ingram. All Rights Reserved.