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An Introduction to Cell Mechanics and Mechanobiology teaches a quantitative understanding of the way cells detect, modify, and respond to the physical properties within the cell environment. Coverage includes the mechanics of single molecule polymers, polymer networks, two-dimensional membranes, whole-cell mechanics, and mechanobiology, as well as primer chapters on solid, fluid, and statistical mechanics. Advanced analyses and mathematical derivations are presented as optional boxes along with solved examples in the main text; each chapter ends with problems and annotated references. The textbook is designed for a one-semester course in the mechanics of the cell offered to senior undergraduate and first year graduate students in biomedical and bioengineering, and mechanical engineering.