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An Introduction to Medicinal Chemistry,9780199234479
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An Introduction to Medicinal Chemistry

by
Edition:
4th
ISBN13:

9780199234479

ISBN10:
0199234477
Format:
Paperback
Pub. Date:
3/25/2009
Publisher(s):
Oxford University Press
List Price: $67.99
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Summary

The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very accessible to students. Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitors to painkillers. The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques. An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses. With enhanced attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading.

Author Biography


Graham Patrick is a lecturer in Organic Chemistry and Medicinal Chemistry at the University of the West of Scotland, Paisley. He is the author of four other undergraduate textbooks covering medicinal chemistry and organic chemistry.

Table of Contents

Drugs and drug targets: an overview
Drug targets: Structure and Function
Protein structure and function
Enzymes: structure and function
Receptors: structure and function
Receptors and signal transduction
Nucleic acids - structure and function
Pharmacodynamics and pharmacokinetics
Enzymes as drug targets
Receptors as drug targets
Nucleic acids as drug targets
Other drug targets
Pharmacokinetics and related topics
Statins
Drug discovery, design, and development
Drug discovery: finding a lead
Drug design: optimizing target interactions
Drug design: optimizing access to the target
Drug development
The design of ACE inhibitors
Artemisinin and related antimalarial drugs
The design of oxamniquine
Tools of the trade
Combinatorial synthesis
Computers in medicinal chemistry
Quantitative structure-activity relationships (QSAR)
De novo design of a thymidylate synthase inhibitor
Design of a serotonin antagonist
Selected topics in medicinal chemistry
Antibacterial agents
Antiviral agents
Anticancer agents
The peripheral nervous system: cholinergics, anticholinergics, and anticholinesterases
The andrenergic nervous system
The opium analgesics
Anti-ulcer agents
Table of Contents provided by Publisher. All Rights Reserved.


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