Ischemic Stroke: Pathways to Treatment

by Del Zoppo, Gregory

• ISBN13: 9781405103671
• ISBN10: 1405103671
• Edition: 1st
• Format: Hardcover
• Copyright: 2015-09-01
• Publisher: BLACKWELL PUBLISHING

Summary

This book will contain ten sections, each of which will include a variable number of chapters describing the scientific and medical basis underlying the acute intervention of ischemic stroke. Each section will be introduced by a 1-2 page summary prepared by a clinican who will discuss the relevance of the section for a clinical audience. This summary will be composed in the form of an editorial in the New England Journal of Medicine. Each sections will deal with the fundamental science of ischemic injury, while subsequent sections will discuss the medical science of ischemic injury, followed by the medical practice. Although several excellent resources exist on this topic, none provide the relevance of this topic in every day use. Now that the field is more stable, direction of clinical practice can easily be provided. Because there are few competing projects at this time, and as the most senior figures in the field will be contributing to this text, it will become the leading text of clinical management of ischemic stroke.

Table of Contents

SECTION PREFACE 1 BASIC PRINCIPLES: PATHOPHYSIOLOGY OF FOCAL CEREBRAL ISCHEMIA Part 1 Focal Cerebral Ischemia Chapter 1 Fundamental Principles of Ischemic Injury in the Central Nervous System Chapter 2 Neuron Receptor Biology: Responses to Ischemia Chapter 3 Neuron/Astroglial Responses to Ischemia: I Human, ii animal models Chapter 4 Microvascular Responses to Ischemic Injury: I Adhesion receptor biology, ii Cellular Interactions Part 2 Inflammatory Processes During Focal Cerebral Ischemia Chapter 5 Inflammatory Cellular Processes During Focal Ischemia Chapter 6 Cytokines in Focal Cerebral Ischemia Part 3 Biochemistry of Vascular Thrombosis and Recanalization Chapter 7 Processes of Thrombosis and Thromboembolism in Arterial Disease Chapter 8 Plasminogen Activators Chapter 9 Coagulation and Platelet Activation During Cerebral Ischemia Part 4 Neuron Responses to Focal Cerebral Ischemia Chapter 10 Nitric Oxide Responses Chapter 11 Neurotransmitter Release Chapter 12 Secondary Injury Cascade SECTION PREFACE 2 BASIC PRINCIPLES: CLINICAL ATTRIBUTES OF FOCAL CEREBRAL ISCHEMIA Part 1 Thrombosis and Thromboembolism in Focal Cerebral Ischemia Chapter 13 Carotid Territory Arterial Occlusion Chapter 14 Vertebrobasilar Territory Occulsion Chapter 15 Lacunar Disease Part 2 Collateral Anastamoses Chapter 16 The Cerebrovascular Arterial Tree and the Relevance of Collaterals: I Human, ii Animal Models SECTION PREFACE 3 WINDOWS FOR INTERVENTION Chapter 17 Experimental Attributes of the Window(s), including species difference Chapter 18 Clinical Attributes Supporting the Nature of Therapeutic Windows and Their Characteristics (PET) Chapter 19 Anatomic Contributions to the Clinical Window Chapter 20 Windows Characteristic of Therapeutic Interventions (based upon pharmacological characteristics of agents, e.g. antithrombotics, mNMDA receptor antagonists) SECTION PREFACE 4 MEASURES OF CLINICAL RESPONSE Part 1 Imagine Approaches Chapter 21 Relevance of the CT Scan to Patient Selection and Follow-up (ECASS/NINDS) Chapter 22 CT Scan-based Assessments Chapter 23 Carotid Angiography: i Normal, ii Cerebral Ischemia Chapter 24 Magnetic Resonance Imaging and Angiography: I normal, ii Cerebral Ischemia Chapter 25 SPECT: i Normal, ii Cerebral Ischemia Chapter 26 Transcranial Doppler Part 2 Clinical Outcome Measures in Clinical Stroke Chapter 27 Validation of Scales Chapter 28 Neurological Scale Scores and Their Utility Chapter 29 Disability Outcomes and Mortality SECTION PREFACE 5 TECHNIQUES FOR DELIVERY Chapter 30 Intravenous Delivery (pharmacological characteristics of individual agents) Chapter 31 Intra-arterial Delivery Systems SECTION PREFACE 6 RISKS Part 1 Hemorrhagic Transformation Chapter 32 Hemorrhagic Transformation (Experimental) Chapter 33 Hemorrhagic Transformation (Clinical) Part 2 Early Mortality Chapter 34 Causes of Early Mortality in Ischemic Stroke SECTION PREFACE 7 THROMBOLYSIS ACUTE FOCAL CEREBRAL ISCHEMIA - EXPERIMENTAL Chapter 35 Perspectives on Experimental Background to Clinical Thrombolysis SECTION PREFACE 8 THROMBOLYSIS IN ACUTE FOCAL CEREBRAL ISCHEMIA - CLINICAL Chapter 36 Utility of Plasminogen Activators in Myocardial Ischemia Relative to Stroke Chapter 37 Intravenous Infusion of Plasminogen, Activators in Focal Cerebral Ischemia: i historical setting, ii u-PA and streptokinase, iii rt-PA, iv future approaches, v other agents<