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Janeway#xE2;#xAC;"s Immunobiology is an introductory textbook for undergraduates, graduate students, and medical students of immunology. It guides the reader through the immune system in all its aspects#xE2;#xAC;#x1D;from the first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. The Eighth Edition has been completely updated as follows: Two separate chapters on innate immunity: Chapter 2 (Innate Immunity: The First Lines of Defense) and Chapter 3 (The Induced Responses of Innate Immunity). Presentation of T cell subset including Th17 development and regulation. Revised treatment of signaling and immune regulation. Addition of new structural information and insight into the mechanisms of innate recognition. Presentation of lymphocyte development. Coverage of the interactions of the commensal gut microbioata with the mucosal immune system (Chapter 12). Evolution is now incorporated throughout the text. Addition of new illustrations throughout the book. Students and instructors will have access to supplements including animations and videos with voiceover narration as well as the figures from the text for presentation purposes. Janeway's Immunobiology continues to set the standard for relevancy and authority with its clear writing style and organization, full-color art program, and scientific accuracy.