9781587061202

The JNK Signaling Pathway

by
  • ISBN13:

    9781587061202

  • ISBN10:

    1587061201

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2006-02-15
  • Publisher: CRC Press

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Table of Contents

Preface
The Structure of the Type 1 Insulin-Like Growth Factor Receptorp. 1
Structure and Function of the IGF-1 and Mannose 6-Phosphate/IGF-2 Receptorsp. 22
IGFBPs - Gene and Protein Structurep. 48
Regulation of Insulin-Like Growth Factor-I Gene Expressionp. 64
The Many Levels of Control of IGF-II Expressionp. 91
IGF-I Receptor Signaling in Health and Diseasep. 104
Insulin-Like Growth Factor-I Stimulation of Growth: Autocrine, Paracrine and/or Endocrine Mechanisms of Action?p. 121
Insulin-Like Growth Factor 1 (IGF1) and Brain Developmentp. 137
IGFs and the Nervous Systemp. 158
The Insulin-Like Growth Factors in Mammary Development and Breast Cancerp. 188
The Insulin-Like Growth Factor System and Bonep. 206
IGFBP-5, a Multifunctional Protein, Is an Important Bone Formation Regulatorp. 219
IGF Action and Skeletal Musclep. 235
Insulin-Like Growth Factor-I and the Kidneyp. 244
IGF-Independent Effects of the IGFBP Superfamilyp. 262
Functional Relationships between Transforming Growth Factor-[beta] and the Insulin-Like Growth Factor Binding Proteinsp. 281
Insulin-Like Growth Factor Binding Proteins (IGFBPs) and Apoptosisp. 294
The Role of Insulin-Like Growth Factor-1 and Extracellular Matrix Protein Interaction in Controlling Cellular Responses to This Growth Factorp. 304
Epidemiologic Approaches to Evaluating Insulin-Like Growth Factor and Cancer Riskp. 317
IGF-I, Insulin and Cancer Risk: Linking the Biology and the Epidemiologyp. 338
The Molecular Basis of IGF-I Receptor Gene Expression in Human Cancerp. 346
Antisense and Triple Helix Strategies in Basic and Clinical Research: Challenge for Gene Therapy of Tumors Expressing IGF-Ip. 357
The IGF System in Breast Cancerp. 367
The Role of the IGF System in Prostate Cancerp. 385
IGFs and Sarcomasp. 390
IGFs and Epithelial Cancerp. 399
Insulin-Like Growth Factors and Hematological Malignanciesp. 410
Metabolic Effects of Insulin-Like Growth Factor I and Growth Hormone in vivo: A Comparisonp. 423
Insulin-Like Growth Factor II (IGF-II) and Non-Islet Cell Tumor Hypoglycemia (NICTH)p. 434
Diabetesp. 441
Insulin-Like Growth Factors in Critical Illnessp. 457
Laron Syndrome: Primary GH Insensitivity or Resistancep. 467
Indexp. 493
Table of Contents provided by Blackwell. All Rights Reserved.

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