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The increasing incidence and prevalence of allergic disease worldwide is one of the most remarkable phenomena of the past 50 years. One in three people in developed countries will experience an allergic condition at some point in their lives and advances in understanding the causes of this trend, and in allergy treatment and care, have captured the imagination of scientists, clinicians and the public. Landmark Papers in Allergyis a definitive collection of over 90 papers charting key discoveries and scientific advances in relation to allergy and the development of treatment and care for allergic disorders. Comprehensive in its coverage, the book includes the first clear descriptions of allergic diseases; the major advances in treatments, such as the discovery of antihistamines, cortisone, biological therapies and immunotherapy; the great immunological advances, such as the discovery of immunoglobulin E (IgE) and leukotrienes; the factors behind the increase in allergy, such as the house dust mite, changes in hygiene and diet; and the growing understanding of the social, psychological and quality-of-life consequences of allergy. Including authoritative commentaries from leading international experts providing reflections on the historical importance and current relevance of each landmark paper,Landmark papers in Allergyis essential reading for any clinician or academic with an interest in allergy.
Table of Contents
SECTION I: 1800-1899 1. Did Bostock Discover Allergic Rhinitis?, Jean Bousquet and Pascal Demoly 2. Early Insights into the Characteristics of Asthma, Gailen D. Marshall, Jr. 3. Identifying Asthma Triggers, Gailen D. Marshall, Jr. 4. Innovative Experiments Which Helped to Unravel the Aetiological Basis of Hay Fever, Aziz Sheikh 5. Asthma Enters the Medical Mainstream, Brian Hurwitz SECTION II: 1900-1949 6. What's in a Name? First Use of the Term 'Allergy', Barry Kay 7. An Innovative Treatment for Food Allergy, Gideon Lack 8. Laying the Foundation for Specific Immunotherapy, Glennis Scadding 9. Celebrating the Case Study: Schloss' Description of Atopic Dermatitis, Torsten Zuberbier 10. Richet's Nobel Lecture, Phil Lieberman 11. A Serendipitous Discovery, Madeleine Ennis 12. Cooke's Early Insights into the Potentially Curative Role of Immunotherapy for Hay Fever, Anthony J Frew and Helen E Smith 13. . Does Eczema Have an Allergic Aetiology?, Michael Ardern-Jones 14. ...and What about Angioedema and Urticaria?, Michael Ardern-Jones 15. Prausnitz, Kustner and the First Diagnostic Test for Allergy, Jonathan Brostoff and A. William Frankland 16. Introducing Atopy, Harold S. Nelson 17. Ephedra - Laying the Foundations for Modern Autonomic Pharmacology, Munir Pirmohammed 18. First Attempts to Unravel the Relationship between Diet and Allergy, Hasan Arshad 19. Demonstrating Serological Changes Induced by Ragweed Extract, N. Franklin Adkinson Jr 20. Bovet's Nobel Prize-winning Discovery of Antihistamines, Martin K Church and Marcus Maurer 21. Identification of Slow-Reacting Substance, Sven-Erik Dahlen 22. Oral Allergy Syndrome, Victoria Cardona and Ignacio J. Ansotegui SECTION III: 1950-1999 23. In Praise of Famous Men: Early Cortisone Studies, Andrew Bush 24. The Relationship between Mast Cells and Histamine, Michael Kaliner 25. What Goes Round Comes Around: Developing Allergen Immunotherapy, Stephen R Durham 26. Burnet, Clonal Selection Theory and Acquired Immunological Tolerance, Sarah Howie 27. Slow-Reacting Substance of Anaphylaxis, Marc Peters-Golden 28. Loveless and Wasp-venom Immunotherapy, Anthony Dubois 29. Developing an Understanding of Mast Cell Biology, Stephen Wasserman 30. Disodium Cromoglycate for Allergic Asthma, Alan Edwards 31. Ancient Egyptian Soup for Treating Asthma: Cox and Intal, Anant Parekh 32. RAST: The Iconic Test for Allergic Sensitisation, Shuaib Nasser 33. The Discovery of IgE, Sami L Bahna 34. Penicillin Allergy: A Model for Practical Clinical Translational Science, Lanny Rosenwasser 35. Unravelling the Relationship between Dermatophagoides Pteronyssinus and Asthma, Angela Simpson 36. The Gell and Coombs Classification, William W. Busse 37. The Dawn of Molecular Allergology, Hannah Gould 38. Immunotherapy Can Change the Natural History of Respiratory Allergy, Walter Canonica 39. Anatomy of the Asthmatic Bronchi, Paul O'Byrne 40. Identifying a Novel Cause of Occupational Allergy, Paul Cullinan and Anthony Newman Taylor 41. Delayed Hypersensitivity to Pollen Allergens, Tom Platts-Mills 42. Inhaled Beclomethasone Dipropionate: Stepping-up Asthma Care, Aziz Sheikh 43. Challenging Notions of the "Atopic Personality", Thomas Ruzicka and Andreas Wollenberg 44. Establishing and Investigating the Relationship between Food Allergy and Asthma, Graham Roberts 45. The "Histamine-Inhalational Test", . Bruce R Thompson and Robyn E O'Hehir 46. Allergic Reactions to Colloid Infusions-Another Chapter in the Colloid Debate, Jasmeet Soar 47. Total and Specific IgE and Allergic Bronchopulmonary Aspergillosis, Paul Greenberger 48. Immunotherapy for Venom Allergy Comes of Age, Richard F. Lockey 49. Extending the Evidence for Immunotherapy to the Management of Children with House Dust Mite Triggered Asthma, Roy Gerth van Wijk 50. Insights from Xhosa into Environmental Risk Factors for the Development of Asthma, Peter Burney 51. Viral Infection, Allergic Sensitisation and Asthma, Jurgen Schwarze 52. Immune Responses in Atopic Eczema, Johannes Ring and Ulf Darsow 53. . Understanding the Relationship between Atopic Sensitisation and Airway Hyper-responsiveness in Asthma, Todor Popov 54. Key Insights into the Relationship between Food Allergy and Atopic Dermatitis, Alessandro Fiocchi 55. From Slow-Reacting Substance of Anaphylaxis to Anti-Leukotrienes, Frank Austen 56. Once More unto the Breach: the Role of the Damaged Bronchial Epithelium in Asthma, Karl Staples and Ratko Djukanovic 57. Management of Anaphylactic Shock, Simon Brown 58. The Hygiene Hypothesis, Graham Devereux 59. In Search of the Elixir for Childhood Allergy and Asthma, Diane Gold 60. A New Way of Considering 'Quality of Life', Allison Worth 61. Food Allergy and Anaphylaxis, Scott Sicherer 62. Allergen Avoidance: The Isle of Wight Study, Sandra Kuiper and Constant P. van Schayck 63. Introducing Sputum Counts, Parameswaran Nair 64. Atopic Asthma is a TH2-cell Mediated Disease, David Ahern 65. Investigating the Impact of Hay Fever on Educational Performance, Samantha M Walker 66. Findings from an Early Peanut Immunotherapy Trial, Tomohiro Utsunomiya and Motohiro Ebisawa 67. Auto-Immune Mechanisms in Chronic Urticaria, Young Min Ye and Hae-Sim Park 68. Air Pollution, Mortality and the Need for Public Health Policy, Frank J Kelly 69. The Geography of Asthma and Atopy: After the Berlin Wall Came Down, Seif Shaheen 70. The Role of Animal Allergens in Allergic Disease, Judith Woodfolk 71. The Natural History of Wheezing: the Tucson Cohort, Innes Asher and Julian R Vyas 72. Measuring Food-Specific IgE Values, Stacy Chin and Wesley Burks 73. Tuberculosis Exposure and Atopy, Mary Linehan 74. The Inner-City Home Environment and Asthma, James Friedlander and Wanda Phipatanakul 75. Mapping the Burden of Allergic Disease in Childhood: ISAAC, Carsten Flohr 76. The Relationship between Obesity and Asthma, David Beuther 77. The Emergence of Monoclonal Antibodies, Michael Daines and Wayne Morgan 78. The Renaissance in Allergen Immunotherapy, John Warner 79. Pet Exposure in Early Life and the Development of Allergy and Asthma, Somnath Mukhopadhyay SECTION IV: 2000-2012 80. Predicting the Development of Childhood Asthma, Denis Ownby 81. IL-5 Blocking Monoclonal Antibody, Andrew J Wardlaw 82. Learning from Anaphylaxis Fatalities, Simon Brown 83. Peanut Allergy and Quality of Life, Audrey DunnGalvin 84. The Janus Face of Endotoxin: for Good and Bad?, Erika von Mutius 85. Testing the 'Hygiene Hypothesis': Probiotics for the Primary Prevention of Atopic Eczema, Carlos Camargo 86. The Impact of Food Allergy on Health-Related Quality of Life, Antonella Muraro 87. Does Idiopathic Eosinophilic Esophagitis have an Allergic Aetiology?, Stephan Bischoff 88. Dawn of the Genomic Age for Asthma, Ian M Adcock 89. Endotoxins, Allergy and Tolerance, Malcolm Sears 90. Inherited Skin-Barrier Defects and Risk of Developing 'Atopic' Eczema, William Cookson 91. Anti-IgE: Biologicals Reach the Inner-cities, Ulrich Wahn 92. Conclusions: From the 18th to the 21st Century, and Beyond..., Tom Platts-Mills, Allison Worth and Aziz Sheikh