Lung Cancer Metastasis

by Keshamouni, Venkateshwar; Arenberg, Douglas; Kalemkerian, Gregory

• ISBN13: 9781441907714
• ISBN10: 1441907718
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-09-08
• Publisher: Springer Verlag

Summary

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include; defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

Table of Contents

Lung Cancer: Overview	p. 1
Hallmarks of Metastasis	p. 29
Tumor Stem Cells and Metastasis	p. 47
Epithelial-Mesenchymal Transition as a Mechanism of Metastasis	p. 65
Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis	p. 93
Immunologic Mechanisms in Lung Carcinogenesis and Metastasis	p. 111
Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis	p. 135
Chemokines in Lung Cancer Metastasis	p. 155
Molecular Control of Lymphatic Metastasis in Lung Cancer	p. 173
Carcinoma-Associated Fibroblasts in Lung Cancer	p. 193
The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer	p. 217
Experimental Animal Models for Studying Lung Cancer	p. 241
Molecular Imaging in Lung Cancer Metastases	p. 267
Biomarker Discovery for Metastatic Disease	p. 289
Current Clinical Management of Metastatic Lung Cancer	p. 317
Site-Directed Therapy for Lung Cancer Metastases	p. 351
Systems Approach for Understanding Metastasis	p. 383
Subject Index	p. 395
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