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WALTER A. KORFMACHER, PhD, is Director of Bioanalysis at Genzyme, a Sanofi company, and Associate Editor at the Journal of Mass Spectrometry. Previously, he held positions at the FDA's National Center for Toxicological Research, Schering-Plough Research Institute, Merck Research Laboratories, and Medpace Bioanalytical Laboratories. Dr. Korfmacher is an international leader in developing mass spectrometry techniques and strategies for new drug discovery and drug metabolism applications. A 2009 recipient of the CPSA Distinguished Analytical Scientist Award, he has published more than 150 articles in the scientific literature and made more than eighty presentations at various scientific forums.
Table of Contents
Walter A. Korfmacher
1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1
2 Utility of High Resolution Mass Spectrometry for New Drug Discovery Applications
William Bart Emary and Nanyan Rena Zhang
3 Quantitative Mass Spectrometry Considerations in a Regulated Environment
Mohammed Jemal and Yuan-Qing Xia
4 Mass Spectrometry for Quantitative in Vitro ADME Assays
Jun Zhang and Wilson Z. Shou
5 Metabolite Identification Using Mass Spectrometry in Drug Development
Natalia Penner, Joanna Zgoda-Pols and Chandra Prakash
6 MS Analysis of Biological Drugs, Proteins and Peptides
Yi Du, John Mehl and Pavlo Pristatsky
7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics
Hui Wei, Guodong Chen and Adrienne A. Tymiak
8 Liquid Extraction Surface Analysis (LESA): a New Mass Spectrometry-Based Technique for Ambient Surface Profiling
Dan Eikel and Jack Henion
9 MS Applications in Support of Medicinal Chemistry Sciences
Maarten Honing, Benno Ingelse and Birendra N. Pramanik
10 Imaging Mass Spectrometry of Proteins and Peptides
Michelle L. Reyzer and Richard M. Caprioli
11 Imaging Mass Spectrometry for Drugs and Metabolites
Stacey R. Oppenheimer
12 Screening Reactive Metabolites: Role of Liquid Chromatography-High Resolution Mass Spectrometry in Combination with 'Intelligent' Data Mining Tools
Shuguang Ma and Swapan K. Chowdhury
13 Mass Spectrometry of siRNA
Mark Cancilla and Mike Flanagan
14 Mass Spectrometry for Metabolomics
Petia Shipkova and Michael D. Reily
15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High Resolution Full Scan?
Lieve Dillen and Filip Cuyckens