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9781889325392

Metabolism : Quick Look Medicine

by
  • ISBN13:

    9781889325392

  • ISBN10:

    1889325392

  • Format: Hardcover
  • Copyright: 1999-10-01
  • Publisher: Wiley-Blackwell
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Summary

Quick Look Metabolism integrates biochemical pathways with themes traditionally covered in physiology, cell structure, histology, and nutrition. Medical students at all levels will find this approach invaluable, especially when trying to grasp the big picture of human metabolism.By integrating multidisciplinary concepts into a concise format, emphasis has been placed on basic principles, functions, and regulation with minimal attention given to metabolic intermediates and tedious structural details. Consideration of particular pathways include descriptions of the function the pathway plays in the cell or the organism as a whole; descriptions of the key reactions in the pathway, including where the reactions occur in the cell; and discussions of the organ specificity of the pathway, how it is regulated, and how it is co-ordinated with other pathways so that homeostasis is maintained. To provide vertical integration, clinical examples are used frequently to emphasise the connection between disease and abnormalities in metabolism.

Table of Contents

Preface vii
Abbreviations ix
PART I: FUNDAMENTALS OF METABOLISM
Cellular Organelles and Their Metabolic Functions
2(2)
Biological Buffers and Acid-Base Equilibrium
4(2)
Protein Structure
6(2)
Collagen: The Major Connective Tissue Protein
8(2)
Plasma Proteins
10(2)
Membrane Structure and Transport Proteins
12(2)
Hemoglobin Structure and Function
14(2)
General Properties of Enzymes
16(2)
Enzyme Kinetics
18(2)
Regulation of Enzyme Activity
20(2)
Transduction of Hormone Signals Across Membranes
22(2)
Nutritional Basis of Metabolism: Macronutrients
24(2)
Nutritional Basis of Metabolism: Micronutrients
26(8)
PART II: BIOENERGETICS
Thermodynamic Principles of Metabolism
34(2)
Oxidative Metabolism
36(2)
Mitochondrial Compartments
38(2)
Catabolic Functions of the TCA Cycle
40(2)
Anabolic Functions of the TCA Cycle
42(2)
Electron Transport Chain: Oxidation of NADH and FADH2
44(2)
Oxidative Phosphorylation: Mitochondrial ATP Synthesis
46(2)
Interconversion of Metabolic Fuels
48(6)
PART III: CARBOHYDRATE METABOLISM
Digestion and Absorption of Carbohydrates
54(2)
Effects of Insulin on Blood Glucose
56(2)
Effects of Glucagon on Blood Glucose
58(2)
Glycolysis
60(2)
Metabolic Fate of Pyruvate
62(2)
Glycogen Metabolism
64(2)
Coordinate Regulation of Glycogen Metabolism
66(2)
Gluconeogenesis
68(2)
Coordinate Regulation of Glycolysis and Gluconeogenesis
70(2)
Pentose Phosphate Pathway
72(2)
Galactose, Fructose, and Glucuronic Acid Metabolism
74(2)
Glycosylation of Proteins
76(2)
Proteoglycans
78(8)
PART IV: LIPID METABOLISM
Lipid Digestion and Absorption
86(2)
Structure and Function of Lipoproteins
88(2)
Chylomicron Metabolism
90(2)
VLDL, IDL, and LDL Metabolism
92(2)
HDL Metabolism
94(2)
Cholesterol and Bile Acid Metabolism
96(2)
Steroid Hormone Metabolism
98(2)
Fatty Acid Synthesis and Storage
100(2)
Fatty Acid Mobilization and Oxidation
102(2)
Ketone Metabolism
104(2)
Coordinate Regulation of Fatty Acid Metabolism
106(2)
Phospholipids
108(2)
Sphingolipid and Glycolipid Metabolism
110(2)
Essential Fatty Acids and Eicosanoid Metabolism
112(8)
PART V: AMINO ACID AND NITROGEN METABOLISM
Dietary Protein Requirement and Nitrogen Balance
120(2)
Protein Digestion and Amino Acid Absorption
122(2)
Interorgan Exchange of Amino Acids
124(2)
Removal of Amino Groups and Disposal of Carbon Skeletons
126(2)
Detoxification of Ammonia
128(2)
Branched-Chain Amino Acid Metabolism and Organic Acidurias
130(2)
Hepatic Aromatic Amino Acid Metabolism
132(2)
Extrahepatic Metabolism of Tyrosine
134(2)
Biogenic Amines Derived from Amino Acids
136(2)
Transfer of One-Carbon Units in Metabolism
138(2)
Metabolism of Sulfur Amino Acids and Peptides
140(2)
Porphyrin and Heme Metabolism
142(2)
Nitric Oxide Metabolism
144(2)
Purine Nucleotide Synthesis
146(2)
Salvaging and Degradation of Purine Nucleotides
148(2)
Pyrimidine Nucleotide Metabolism
150(8)
PART VI: INTEGRATION OF METABOLISM
Organizing Themes in Metabolism
158(2)
Branch Points in Metabolism
160(2)
Tissue and Subcellular Specialization
162(2)
Liver: The Nutrient Clearing Center
164(2)
Glucose Homeostasis During Fasting
166(2)
Hepatic Fuel Metabolism in the Well-Fed State
168(2)
Hepatic Fuel Metabolism in the Fasting State
170(2)
Metabolic Changes in Diabetes Mellitus
172(2)
Effect of Ethanol on Metabolism
174(2)
Inheritance Patterns of Metabolic Diseases
176(9)
Index 185

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