9783527322831

Modern Biopharmaceuticals Recent Success Stories

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  • ISBN13:

    9783527322831

  • ISBN10:

    3527322833

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 5/28/2013
  • Publisher: Wiley-Blackwell
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Summary

This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals.

Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.

Author Biography

Dr. J?rg Kn?blein studied Biotechnology / Chemical Engineering at the Society for Biotechnology Research (GBF) in Braunschweig, Germany and Biochemistry at the Max-Planck-Institute for Biochemistry. He received his Ph.D. from the Max-Planck-Institute for Biochemistry in Martinsried / Munich where he worked in the group of Professor Robert Huber (Nobelprize laureate in 1988). J?rg Kn?blein holds a leading position in technology scouting at Bayer Schering Pharma AG, Berlin.


AWARDS:
Riedel-de Haen-Stiftung
Government / Ministry of Science
Nomination for the Max-Buchner-Award from DECHEMA (Society for Biotechnology and Chemical Engineering)
Winner of the McKinsey business plan contest

Table of Contents

Twenty Thousand Years of Biotech ? from Traditional to Modern Biotechnology
MODERN BIOPHARMACEUTICAL DEVELOPMENT USING STEM CELLS, TISSUES, AND WHOLE ANIMALS
iPS as substitute of SCNT? ? The Impact of induced pluripotent stem cells on drug discovery and regenerative biopharmaceuticals
BIOheart: An Engineered Heart Tissue Spontaneously Starts Pumping
Industrialization of Functional Mouse Genomics for Biopharmaceutical Development
Zinc Finger Nucleases: A Novel Technology for Targeted Genome Editing and Biopharmaceutical Development
INNOVATIVE DEVELOPMENT TOOLS FOR MODERN BIOPHARMACEUTICALS
Standardized Solutions for Quantitative Real-time PCR To Accelerate Biopharmaceutical Development
Massive Mutagenesis?: The Path to Smarter Genetic Libraries for Effective Biopharmaceuticals
FastDigest? With All Restriction Enzymes @same Temperature and Buffer: A New Paradigm in DNA Digestion to Speed-up Biopharmaceutical Development
StarGate?: A high capacity expression cloning system to speed up biopharmaceutical development
Precision Genome Surgery With Meganucleases: A Promising Biopharmaceutical for Gene Therapy
Revolutionizing biopharmaceutical development with quantitative multi-spectral opto-acoustic tomography (MSOT)
Pharma Research Biobanking: need, socioethical considerations, and best practise
THE RISE OF MONOCLONAL ANTIBODIES ? THE PREMIUM CLASS OF BIOPHARMACEUTICALS
Implementation of current advanced technology in commercial Mab production
Erbitux ? ? The First Monoclonal IgG1 Antibody Blocking EGFR
Novel Human Antibodies against Cancer ? HuMAb and UniBody
SMART SOLUTIONS FOR GLOBAL CHALLANGES ? VACCINE-BASED BIOPHARMACEUTICALS
A Modern Biopharmaceutical to Treat AIDS ? Challenges in Designing HIV Env Immunogens for Developing a Vaccine
Superfast Biopharmaceutical Development ? Vero Cell technology and Pandemic Influenza Vaccine Production
MODERN BIOPHARMACEUTICALS ? THE HOLY GRAIL FOR HEALTH AND WEALTH
BioBenchmarking: the Global Perspective to Ensure Future Success of Biopharmaceutical Development
Medicinal Biotechnology ? A European Snapshot of Biopharmaceutical Use in Germany
Experience with Omnitrope?, the first ever approved similar biopharmaceutical product
KOGENATE? ? The First Continuous Infusion for Haemophilia Treatment During Surgery
FROM INNOVATIVE TOOLS TO IMPROVED THERAPIES ? THE SUCCESS OF SECOND-GENERATION BIOPHARMACEUTICALS
Post-translational Modifications to Improve Biopharmaceuticals
High-throughput Biomaterials-mediated Delivery of DNA and siRNA Biopharmaceuticals
BIOPHARMACEUTICAL MANUFACTURING AND DOWNSTREAM PROCESSING ? HOW TO UNCORK BOTTLENECKS
Improving Biopharmaceutical R&D and Manufacturing Strategies and Workflows
Large scale manufacturing of biopharmaceuticals: speed up the road to market ? 6x 15,000 liter BI bioreactors
Large Scale Purification of Biopharmaceuticals by Affinity Tag
In-situ On-line Monitoring of Fermentation Processes: A Cool Tool for Biopharmaceutical Production
Queen honeybee & me: forever young? Conserved pathways for longevity

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