This book offers comprehensive coverage of the general principles governing the structures and functions of both procaryotic and eucaryotic genes, including the molecular biology of yeast and recombinant DNA methodology. It also addresses the specialized aspects of the gene that underlie multicellular existence, including detailed discussion of development, immunogenetics, eucaryotic viruses, and cancer. The final chapter discusses the evolution of the gene.
VOLUME I: General Principles.
PART 1: HISTORICAL BACKGROUND.
1 The Mendelian view of the World.
2 Cells Obey the Laws of Chemistry.
3 Nucleic Acids Convey Genetic Information.
PART II: CHEMICAL FACTS AND PRINCIPLES.
4 A Chemist's Look at the Bacterial Cell.
5 The Importance of Weak Chemical Interactions.
6 Coupled Reactions and Group Transfers.
PART III: BACTERIAL GENETICS.
7 The Genetic Systems Provided by E. Coli and Its Viruses.
8 The Fine Structure of Bacterial and Phase Genes.
PART IV: DNA IN DETAIL.
9 The Structures of DNA.
10 The Replication of DNA.
11 Recombination at the Molecular Level.
12 The Mutability and Repair of DNA.
PART V: THE STEPS IN PROTEIN SYNTHESIS.
13 The Synthesis of RNA upon DNA Templates.
14 Involvement of RNA in Protein Synthesis.
15 The Genetic Code.
PART VI: REGULATION OF GENE FUNCTION IN BACTERIAL CELLS.
16 Regulation of Protein Synthesis and Function in Bacteria.
17 The Replication of Bacterial Viruses.
PART VII: FACING UP TO EUKARYOTIC CELLS.
18 Yeasts as the E. coli of Eukaryotic Cells.
19 Recombinant DNA at Work.
PART VIII: THE FUNCTIONING OF EUKARYOTIC CHROMOSOME.
20 The Unexpected Structures of Eukaryotic Genomes.
21 The Functioning of Higher Eukaryotic Genes.
VOLUME II: Specialized Aspects.
PART IX: GENE FUNCTION IN SPECIALIZED EUKARYOTIC SYSTEMS.
22 The Molecular Biology of Development.
23 The Generation of Immunological Specificity.
24 The Extraordinary Diversity of Eukaryotic viruses.
PART X: CANCER AT THE GENETIC LEVEL.
25 The Control of Cell Proliferation.
26 The Genetic Basis of Cancer.
27 The Origins of Human Cancer.
PART XI: EVOLUTION OF THE GENE.
28 The Origins of Life.