9781429234139

Molecular Cell Biology

by ; ; ; ; ; ; ;
  • ISBN13:

    9781429234139

  • ISBN10:

    142923413X

  • Edition: 7th
  • Format: Hardcover
  • Copyright: 5/2/2012
  • Publisher: W. H. Freeman

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Summary

Molecular Cell Biologypresents the key concepts in cell biology and their experimental underpinnings. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. As always, a hallmark of MCBis the use of experiments to engage students in the history of cell biology and the research that has contributed to the field.

Table of Contents

Molecules, Cells, and Evolution
The Molecules of Life
Genomes, Cell Architecture, and Cell Function
Cells into Tissues-Unicellular and Metazoan Organisms Used for Molecular Cell Biology Investigations
Chemical Foundations
Covalent Bonds and Noncovalent Interactions
Chemical Building Blocks of Cells
Chemical Reactions and Equilibrium
Biochemical Energetics
Protein Structure and Function
Hierarchical Structure of Proteins
Protein Folding
Protein Binding and Enzyme Catalysis
Regulating Protein Function
Purifying, Detecting, and Characterizing Proteins
Proteomics
Basic Molecular Genetic Mechanisms
Structure of Nucleic Acids
Transcription of Protein-Coding Genes and Formation of Functional mRNA
The Decoding of mRNA by tRNAs
Stepwise Synthesis of Proteins on Ribosomes
DNA Replication
DNA Repair and Recombination
Viruses: Parasites of the Cellular Genetic System
Molecular Genetic Techniques
Genetic Analysis of Mutations to Identify and Study Genes
DNA Cloning and Characterization
Using Cloned DNA Fragments to Study Gene Expression
Locating and Identifying Human Disease Genes
Inactivating the Function of Specific Genes in Eukaryotes
Genes, Genomics, and Chromosomes
Eukaryotic Gene Structure
Chromosomal Organization of Genes and Noncoding DNA
Transposable (Mobile) DNA Elements
Organelle DNAs
Genomics: Genome-wide Analysis of Gene Structure and Expression
Structural Organization of Eukaryotic Chromosomes
Morphology and Functional Elements of Eukaryotic Chromosomes
Transcriptional Control of Gene Expression
Overview of Eukaryotic Gene Control
RNA Polymerase II and the General Transcription Factors Required for Initiation
Regulatory Sequences in Protein-Coding Genes and the Proteins Through Which They Function
Molecular Mechanisms of Transcription Repression and Activation
Regulation of Transcription-Factor Activity
Epigenetic Regulation of Transcription
Other Eukaryotic Transcription Systems
Post-Transcriptional Gene Control
Processing of Eukaryotic Pre-mRNA
Regulation of Pre-mRNA Processing
Transport of mRNA Across the Nuclear Envelope
Cytoplasmic Mechanisms of Post-transcriptional Control
Processing of rRNA and tRNA
Culturing, Visualizing, and Perturbing Cells
Growing Cells in Culture
Light Microscopy: Exploring Cell Structure and Visualizing Proteins within Cells
Electron Microscopy: High-Resolution Imaging
Isolation and Characterization of Cell Organelles
Perturbing Specific Cell Functions
Biomembrane Structure
The Phospholipid Bilayer: Composition and Structural Organization
Membrane Proteins: Structure and Basic Functions
Phospholipids, Sphingolipids, and Cholesterol: Synthesis and Intracellular Movements
Transmembrane Transport of Ions and Small Molecules
Overview of Transmembrane Transport
Facilitated Transport of Glucose and Water
ATP-Powered Pumps and the Intracellular Ionic Environment
Nongated Ion Channels and the Resting Membrane Potential
Cotransport by Symporters and Antiporters
Transcellular Transport
Cellular Energetics
First Step of Harvesting Energy from Glucose: Glycolysis
Mitochondria and the Citric Acid Cycle
The Electron Transport Chain and Generation of the Proton-Motive Force
Harnessing the Proton-Motive Force to Synthesize ATP
Photosynthesis and Light-Absorbing Pigments
Molecular Analysis of Photosystems
CO2 Metabolism During Photosynthesis
Moving Proteins Into Membranes and Organelles
Insertion of Membrane Proteins into the ER
Protein Modifications, Folding, and Quality Control in the ER
Targeting of Proteins to Mitochondria and Chloroplasts
Targeting of Peroxisomal Proteins
Transport into and out of the Nucleus
Vesicular Traffic, Secretion, and Endocytosis
Techniques for Studying the Secretory Pathway
Molecular Mechanisms of Vesicular Budding and Fusion
Early Stages of the Secretory Pathway
Later Stages of the Secretory Pathway
Receptor-Mediated Endocytosis
Directing Membrane Proteins and Cytosolic Materials to the Lysosome
Signal Transduction and G Protein-Coupled Receptors
Signal Transduction: From Extracellular Signal to Cellular Response
Studying Cell-Surface Receptors and Signal Transduction Proteins
G Protein-Coupled Receptors: Structure and Mechanism
G Protein-Coupled Receptors That Regulate Ion Channels
G Protein-Coupled Receptors That Activate or Inhibit Adenylyl Cyclase
G Protein-Coupled Receptors That Trigger Elevations in Cytosolic Ca2+
Signaling Pathways That Control Gene Expression
Receptors That Activate Protein Tyrosine Kinases
The Ras/MAP Kinase Pathway
Phosphoinositide Signaling Pathways
Receptor Serine Kinases That Activate Smads
Signaling Pathways Controlled by Ubiquitination: Wnt, Hedgehog, and NF-kB
Signaling Pathways Controlled by Protein Cleavage: Notch/Delta, SREBP
Integration of Cellular Responses to Multiple Signaling Pathways
Cell Organization and Movement I: Microfilaments
Microfilaments and Actin Structures
Dynamics of Actin Filaments
Mechanisms of Actin Filament Assembly
Organization of Actin-Based Cellular Structures
Myosins: Actin-Based Motor Proteins
Myosin-Powered Movements
Cell Migration: Mechanism, Signaling and Chemotaxis
Cell Organization and Movement II: Microtubules and Intermediate Filaments
Microtubule Structure and Organization
Microtubule Dynamics
Regulation of Microtubule Structure and Dynamics
Kinesins and Dyneins: Microtubule-Based Motor Proteins
Cilia and Flagella: Microtubule-Based Surface Structures
Mitosis
Intermediate Filaments
Coordination and Cooperation between Cytoskeletal Elements
The Eukaryotic Cell Cycle
Overview of the Cell Cycle and its Control
Model Organisms and Methods to Study the Cell Cycle
Regulation of CDK Activity
Commitment to the Cell Cycle and DNA Replication
Entry into Mitosis
Completion of Mitosis: Chromosome Segregation and Exit from Mitosis
Surveillance Mechanisms in Cell Cycle Regulation
Meiosis: A Special Type of Cell Division
Integrating Cells Into Tissues
Cell-Cell and Cell-Matrix Adhesion: An Overview
Cell-Cell and Cell-ECM Junctions and Their Adhesion Molecules
The Extracellular Matrix I: The Basal Lamina
The Extracellular Matrix II: Connective Tissue
Adhesive Interactions in Motile and Nonmotile Cells
Plant Tissues
Stem Cells, Cell Asymmetry, and Cell Death
Early Metazoan Development and Embryonic Stem Cells
Stem Cells and Niches in Multicellular Organisms
Regulation of Asymmetric Cell Division
Cell Death and Its Regulation
Nerve Cells
Neurons and Glia: Building Blocks of the Nervous System
Voltage-Gated Ion Channels and the Propagation of Action Potentials
Communication at Synapses
Sensing the Environment: Touch, Pain, Taste, and Smell
Immunology
Overview of Host Defenses
Immunoglobulins: Structure and Function
Generation of Antibody Diversity and B-Cell Development
The MHC and Antigen Presentation
T Cells, T-Cell Receptors, and T-Cell Development
Collaboration of Immune-System Cells in the Adaptive Response
Cancer
Tumor Cells and the Onset of Cancer
The Genetic Basis of Cancer
Cancer and the Misregulation of Growth Regulatory Pathways
Cancer and Mutation of Cell Division and Checkpoint Regulators
Carcinogens and Caretaker Genes in Cancer
Table of Contents provided by Publisher. All Rights Reserved.

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