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With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on key experiments, Molecular Cell Biology has justly earned an impeccable reputation as an exciting and authoritative text. Avoiding an encyclopedic approach, the book grounds its coverage in the experiments that define our understanding of cell biology, engaging students with the exciting breakthroughs that define the field’s history and point to its future. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease.
Harvey Lodish is Professor of Biology and Professor of Bioengineering at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF-ß receptors. His lab also studies hematopoietic stem cells and has identified novel proteins that support their proliferation. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology.
Arnold Berk is Professor of Microbiology, Immunology and Molecular Genetics and a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the original discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription nitiation in mammalian cells, focusing particular attention on transcription factors encoded by oncogenes and tumor suppressors. He teaches introductory courses in molecular biology and virology and an advanced course in cell biology of the nucleus.
Chris A. Kaiser is Professor and Head of the Department of Biology at the Massachusetts Institute of Technology. His laboratory uses genetic and cell biological methods to understand the basic processes of how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top undergraduate educator at MIT, where he has taught genetics to undergraduates for many years.
Monty Krieger is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for the movement of cholesterol into and out of cells, including the HDL receptor.
Anthony Bretscher is Professor of Cell Biology at Cornell University. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton, and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. Dr. Bretscher teaches cell biology to graduate students at Cornell University.
Hidde Ploegh is Professor of Biology at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. One of the world’s leading researchers in immune system behavior, Dr. Ploegh studies the various tactics that viruses employ to evade our immune responses, and the ways in which our immune system distinguishes friend from foe. Dr. Ploegh teaches immunology to undergraduate students at Harvard University and MIT.
Angelika Amon is Professor of Biology at the Massachusetts Institute of Technology, a member of the Koch Institute for Integrative Cancer Research, and Investigator at the Howard Hughes Medical Institute. She is also a member of the National Academy of Sciences. Her laboratory studies the molecular mechanisms that govern chromosome segregation during mitosis and meiosis and the consequences—aneuploidy—when these mechanisms fail during normal cell proliferation and cancer development. Dr. Amon teaches undergraduate and graduate courses in cell biology and genetics.
Matthew P. Scott is Professor of Developmental Biology, Genetics and Bioengineering at Stanford University School of Medicine and Investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and a past president of the Society for Developmental Biology. He is known for his work in developmental biology and genetics, particularly in areas of cell-cell signaling and homeobox genes and for discovering the roles of developmental regulators in cancer. Dr. Scott teaches cell and developmental biology to undergraduate students, development and disease mechanisms to medical students and developmental biology to graduate students at Stanford University
Table of Contents
Table of Contents with New Discoveries and Methodologies
Part I. Chemical and Molecular Foundations 1. Molecules, Cells, and Model Organisms Model organisms Chlamydomonas reinhardtii (for study of flagella, chloroplast formation, photosynthesis, and phototaxis) and Plasmodium falciparum (novel organelles and a complex life cycle) 2. Chemical Foundations3. Protein Structure and Function Intrinsically disordered proteins Chaperone-guided folding and updated chaperone structures Unfolded proteins and the amyloid state and disease Hydrogen/deuterium exchange mass spectrometry (HXMS) Phosphoproteomics 4. Culturing and Visualizing Cells Two-photon excitation microscopy Light sheet microscopy Super resolution microscopy 3D culture matricies and 3D printing Part II. Biomembranes, Genes, and Gene Regulation 5. Fundamental Molecular Genetic Mechanisms Ribosome structural comparison across domains shows conserved core 6. Molecular Genetic Techniques CRISPR/Cas9 system in bacteria and its application in genomic editing 7. Biomembrane Structure8. Genes, Genomics, and Chromosomes Chromosome conformation capture techniques reveal topological domains in chromosome territories within the nucleus 9. Transcriptional Control of Gene Expression DNase I hypersensitivity mapping reveals cell developmental history Long non-coding RNAs involved in X-inactivation in mammals ENCODE databases 10. Post-transcriptional Gene Control Improved discussion of mRNA degradation pathways and RNA surveillance in the cytoplasm Nuclear bodies: P bodies, Cajal bodies, histone locus bodies, speckles, paraspeckles, and PML-nuclear bodies Part III. Cellular Organization and Function 11. Transmembrane Transport of Ions and Small Molecules GLUT1 molecular model and transport cycle 12. Cellular Energetics13. Moving Proteins into Membranes and Organelles Expanded discussion of the pathway for import of PTS1-bearing proteins into the peroxisomal matrix14. Vesicular Traffic, Secretion, and Endocytosis Expanded discussion of Rab proteins and their role in vesicle fusion with target membranes15. Signal Transduction and G Protein–Coupled Receptors Human G protein-coupled receptors of pharmaceutical importance16. Signaling Pathways That Control Gene Expression Wnt concentration gradients in planaria development and regeneration Inflammatory hormones in adipose cell function and obesity Regulation of insulin and glucagon function in control of blood glucose17. Cell Organization and Movement I: Microfilaments Use of troponins as an indicator of the severity of a heart attack18. Cell Organization and Movement II: Microtubules and Intermediate Filaments Neurofilaments and keratins involved in skin integrity, epidermolysus bullosa simplex New structures and understanding of function of dynein and dynactin19. The Eukaryotic Cell Cycle The Hippo pathway Spindle checkpoint assembly and nondisjunction and aneuploidy in mice, and nondisjunction increases with maternal age Part IV. Cell Growth and Differentiation 20. Integrating Cells Into Tissues Expanded discussion of the functions of the extracellular matrix and the role of cells in assembling it Mechanotransduction Structure of cadherins and their cis and trans interactions Cadherins as receptors for Class C rhinoviruses and asthma Improved discussion of microfibrils in elastic tissue and in LTBP-mediated TGF-B signaling Tunneling nanotubes Functions of WAKs in plants as pectin receptors21. Stem Cells, Cell Asymmetry, and Cell Death Pluripotency of mouse ES cells and the potential of differentiated cells derived from iPS and ES cells in treating various diseases Pluripotent ES cells in planaria Cells in intestinal crypts can dedifferentiate to replenish intestinal stem cells Cdc42 and feedback loops that control cell polarity22. Cells of the Nervous System Prokaryotic voltage-gated Na+ channel structure, allowing comparison with voltage-gated K+ channels Optogenetics techniques for linking neural circuits with behavior Mechanisms of synaptic plasticity that govern learning and memory23. Immunology Inflammasomes and non-TLR nucleic sensors Expanded discussion of somatic hypermutation Improved discussion of the MHC molecule classes, MHC-peptide complexes and their interactions with T-cells Lineage commitment of T cells Tumor immunology24. Cancer The characteristics of cancer cells and how they differ from normal cells How carcinogens lead to mutations and how mutations accumulate to cancer