Molecular Medical Parasitology

by Marr; Nilsen; Komuniecki

• ISBN13: 9780124733466
• ISBN10: 0124733468
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-12-31
• Publisher: Elsevier Science

Summary

A valuable, new source, Molecular Medical Parasitology is the only text of its kind -- one that applies broad concepts and current scientific advances from both molecular biology and biochemistry to the study of parasitic organisms. An internationally renowned team of scientists and physicians places parasites in their broad biological contexts while still emphasizing the specifics that differentiate these organisms. Not only will researchers and faculty in parasitology find this an indispensable guide, physicians will benefit from the thorough coverage molecular biology and biochemistry's current influences on treatment and management of parasitic diseases. Key Features * Features the most up-to-date scientific methods behind the medical management of parasitic diseases * Applies the most current synthesis of molecular biology and biochemistry to parasitic organisms * Contains many informative figures and clear illustrations

Table of Contents

List of contributors	p. vii
Preface	p. xi
Molecular Biology	p. 1
Parasite genomics	p. 3
RNA processing in parasitic organisms: trans-splicing and RNA editing	p. 29
Transcription	p. 47
Post-transcriptional regulation	p. 67
Antigenic variation in African trypanosomes and malaria	p. 89
Genetic and genomic approaches to the analysis of Leishmania virulence	p. 111
Biochemistry and Cell Biology: Protozoa	p. 123
Energy metabolism
Anaerobic protozoa	p. 125
Aerobic protists - trypanosomatidae	p. 140
Energy metabolism in the Apicomplexa	p. 154
Amino acid and protein metabolism	p. 171
Purine and pyrimidine transport and metabolism	p. 197
Trypanosomatid surface and secreted carbohydrates	p. 225
Intracellular signaling	p. 241
Plastids, mitochondria, and hydrogenosomes	p. 277
Biochemistry and Cell Biology: Helminths	p. 295
Helminth surfaces: structural, molecular and functional properties	p. 297
Carbohydrate and energy metabolism in parasitic helminths	p. 339
Neurotransmitters	p. 359
Medical Applications	p. 395
Drug resistance in parasites	p. 397
Medical implications of molecular parasitology	p. 433
Index	p. 463
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