Molecularly Targeted Therapy for Childhood Cancer

by Houghton, Peter J.; Arceci, Robert J.

• ISBN13: 9780387690605
• ISBN10: 0387690603
• Format: Hardcover
• Copyright: 2010-10-02
• Publisher: Springer Verlag

Summary

This book will be the first to comprehensively explore the molecular aspects of childhood cancers that make them vulnerable to certain potential therapeutic approaches.

Table of Contents

Hematologic Malignancies
The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia	p. 3
Molecular Targeted Therapies in T-CellAcute Lymphoblastic Leukemia	p. 19
Molecularly Targeted Therapy for Infant ALL	p. 31
Targeted Therapeutic Approaches for AML	p. 59
Acute Promyelocytic Leukaemia	p. 83
Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy	p. 109
Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML)	p. 123
Chronic Myeloid Leukemia: Pathophysiology and Therapeutics	p. 139
Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes	p. 155
New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma	p. 177
Molecular Targeting of Post-transplant Lymphoproliferative Disorders	p. 215
Solid Tumors
Molecularly Targeted Therapies for Astrocytomas	p. 231
Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer	p. 267
Future Treatments of Ependymoma	p. 291
Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INII/hSNF5 Tumor Suppressor	p. 305
Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors	p. 331
Molecular Therapy for Neuroblastoma	p. 351
Ewing's Sarcoma Family of Tumors: Molecular Targets Need Arrows	p. 373
Molecular Targeted Therapy for Wilms' Tumor	p. 401
Molecular Therapy for Rhabdomyosarcoma	p. 425
Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here?	p. 459
Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology	p. 499
Index	p. 521
Table of Contents provided by Ingram. All Rights Reserved.