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In this book, Professor Victor Dubowitz and his colleagues manage to bridge the gap between clinical syndromes and disorders and their underlying pathologies. An internationally renowned resource in the field of muscle disease, this textbook skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease. Comprehensive. Covers the entire range of diagnostic and investigative techniques, providing the clinician/pathologist with all of the necessary tools to formulate an accurate diagnosis. Unique perspective. Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis. Up-toDate. Addresses the "knowledge explosion" over the last 10 years in the fields of molecular genetics and immunohistochemistry, includes all of the latest clinically relevant investigative techniques. Visual guide. Full color images throughout. Provides the user with a comprehensive visual guide to recognition and interpretation. Reference/Bench book. Focuses on diagnostic techniques and on the diagnostic interpretation of results to provide the reader with a portable reference book and a bench book in a single volume. Major areas of update are: update on recent causative genes and their pathological significance in all areas Update on application of immunohistochemistry- ie new primary and secondary defects that can be identified with immunohistochemistry New table in ch 7 on clinical features that help the pathologist consider a disorder Mitochondrial and lipid myopathies (CH18)- completely rewritten- new tables of clinical and pathological features Glycogenoses (ch 17) rewirtten and updated ch 16 new chapter- myopathies with vacuoles ch 19 new chapter- systemic disorders and ageing Ch 20 inflammatory myopathies- update on all conditions, including necrotizing myopathies and inclusion body myositis, Ch 23 update on toxic myopathies, including effects of statins