Nathan and Oski's Hematology of Infancy and Childhood

by Nathan, Orkin, Look & Ginsburg

• ISBN13: 9780721693170
• ISBN10: 0721693172
• Edition: 6th
• Format: Hardcover
• Copyright: 2003-06-16
• Publisher: Saunders

Summary

Presenting the New Edition of the classic reference on pediatric hematology and oncology. Comprehensively revised and updated, it continues to integrate lucid reviews of the pathophysiology of disease with detailed clinical guidance on its diagnosis and management. Drs. Nathan and Orkin - joined by two new co-editors and an outstanding team of authors - worked tirelessly to ensure that all the latest scientific advances appear in the 6th Edition. Nearly 50% of the chapters have been rewritten for the 6th Edition; the remaining chapters have been thoroughly revised and updated. Two new co-editors, Dr. Thomas Look and Dr. David Ginsburg, who contribute their expertise to the neoplastic diseases and coagulation sections. Important new coverage of transfusion medicine, stem cell transplantation protocols, the hematologic manifestations of pediatric AIDS/HIV, and more. The recently codified WHO classification for all lymphomas and leukemias.

Table of Contents

I. History	1	(16)
Pediatric Hematology in Historical Perspective	3	(14)
Wolf W. Zuelzer
II. Neonatal Hematology	17	(152)
The Neonatal Erythrocyte and Its Disorders	19	(37)
Carlo Brugnara
Orah S. Platt
Immune Hemolytic Disease	56	(30)
Helen G. Liley
Disorders of Bilirubin Metabolism	86	(35)
Peter F. Whitington
Estella M. Alonso
Developmental Hemostasis: Relevance to Newborns and Infants	121	(48)
Paul Monagle
Maureen Andrew
III. Bone Marrow Failure	169	(238)
The Anatomy and Physiology of Hematopoiesis	171	(85)
Steven C. Clark
Colin A. Sieff
Acquired Aplastic Anemia	256	(24)
Akiko Shimamura
Eva C. Guinan
Inherited Bone Marrow Failure Syndromes	280	(86)
Blanche P. Alter
Principles of Bone Marrow and Stem Cell Transplantation	366	(41)
Leslie Lehmann
W. Nicholas Haining
Eva C. Guinan
IV. Disorders of Erythrocyte Production	407	(112)
A Diagnostic Approach to the Anemic Patient	409	(10)
Frank A. Oski
Carlo Brugnara
David G. Nathan
Megaloblastic Anemia	419	(37)
V. Michael Whitehead
David S. Rosenblatt
Bernard A. Cooper
Disorders of Iron Metabolism and Sideroblastic Anemia	456	(42)
Nancy C. Andrews
The Porphyrias	498	(21)
Shigeru Sassa
Atallah Kappas
V. Hemolytic Anemias	519	(224)
Autoimmune Hemolytic Anemia	521	(39)
Russell E. Ware
Disorders of the Erythrocyte Membrane	560	(125)
Patrick G. Gallagher
Samuel E. Lux
Pyruvate Kinase Deficiency and Disorders of Glycolysis	685	(36)
William C. Mentzer, Jr.
Glucose-6-Phosphate Dehydrogenase Deficiency and Hemolytic Anemia	721	(22)
Lucio Luzzatto
VI. Disorders of Hemoglobin	743	(178)
Hemoglobins: Normal and Abnormal	745	(45)
Ronald L. Nagel
Sickle Cell Disease	790	(52)
George J. Dover
Orah S. Platt
The Thalassemias	842	(79)
Stuart H. Orkin
David G. Nathan
VII. The Phagocyte System	921	(90)
The Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function	923	(88)
Mary C. Dinauer
Index	i
VIII. The Immune System	1011	(68)
Cell-Mediated and Humoral Immunity and the Regulation of Immune Responses	1013	(30)
Barbara E. Bierer
Primary Immunodeficiency Diseases	1043	(36)
Francisco A. Bonilla
Raif S. Geha
IX. Oncology	1079	(318)
Epidemiology of Leukemia in Childhood	1081	(20)
Smita Bhatia
Leslie L. Robinson
Chromosomal Abnormalities in Childhood Hematologic Malignant Disease	1101	(34)
Harold J. Olney
Alessandro Gozzetti
Janet D. Rowley
Acute Lymphoblastic Leukemia	1135	(32)
Lewis B. Silverman
Stephen E. Sallan
Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children	1167	(43)
Carolyn Bennett
Karl Hsu
A. Thomas Look
Acute Leukemia in Infants	1210	(9)
Gregory H. Reaman
The Molecular Basis of Hematologic Malignancy	1219	(40)
Todd R. Golub
Minimal Residual Leukemia	1259	(15)
John G. Gribben
Pharmacology of Antineoplastic Agents and Multidrug Resistance	1274	(33)
Stacey L. Berg
David G. Poplack
Cell, Cytokine, Monoclonal Antibody, and Gene Therapy	1307	(26)
Paul M. Sondel
Kenneth B. DeSantes
The Lymphomas and Lymphadenopathy	1333	(42)
Michael P. Link
Sarah S. Donaldson
Lymphohistiocytic Disorders	1375	(22)
John L. Sullivan
Bruce A. Woda
X. Storage Diseases	1397	(58)
Storage Diseases of the Reticuloendothelial System	1399	(56)
Edwin H. Kolodny
Gustavo Charria-Ortiz
XI. Hemostasis	1455	(214)
Blood Platelets and the Vessel Wall	1457	(18)
Robert I. Handin
Blood Coagulation	1475	(22)
Charles T. Esmon
The Molecular Basis of Fibrinolysis	1497	(18)
Katherine Amberson Hajjar
Clinical and Laboratory Approach to the Patient with Bleeding	1515	(12)
Jeanne M. Lusher
Inherited Platelet Disorders	1527	(20)
Mortimer Poncz
Hemophilia and von Willebrand Disease	1547	(30)
Robert R. Montgomery
Joan Cox Gill
J. Paul Scott
Rare Hereditary Coagulation Factor Abnormalities	1577	(6)
Kenneth A. Bauer
Inherited Disorders of Thrombosis and Fibrinolysis	1583	(14)
Kenneth A. Bauer
Acquired Platelet Defects	1597	(34)
David B. Wilson
Acquired Disorders of Hemostasis	1631	(38)
Paul Monagle
Maureen Andrew
XII. Supportive Therapy	1669	(88)
Psychologic Aspects of Leukemia and Hematologic Disorders	1671	(13)
Elissa Jelalian
Julie Boergers
Anthony Spirito
Barbara Sourkes
Infectious Complications in Children with Hematologic Disorders	1684	(25)
Andrew Y. Koh
Philip A. Pizzo
Transfusion Medicine	1709	(48)
Steven R. Sloan
Richard J. Benjamin
David F. Friedman
Iain J. Webb
Leslie Silberstein
XIII. Hematologic Manifestations of Systemic Diseases	1757	(78)
Hematologic Manifestations of Systemic Diseases	1759	(51)
R. Alan B. Ezekowitz
James A. Stockman III
Hematologic Manifestations of Systemic Diseases in Children of the Developing World	1810	(25)
David Weatherall
Dominic Kwiatkowski
Appendices	1835
Reference Values in Early Childhood	1835
Carlo Brugnara
Index	i