Neuroglia

by Kettenmann, Helmut; Ransom, Bruce R.

• ISBN13: 9780199794591
• ISBN10: 0199794596
• Edition: 3rd
• Format: Hardcover
• Copyright: 2012-12-28
• Publisher: Oxford University Press

Summary

Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. More than 20 new chapters have been added to accommodate the unprecedented growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function. Lavishly illustrated and meticulously edited, the third edition remains the most convenient and maximally useful reference available. This new edition is an essential reference for both newcomers to the field as well as established investigators. Neuroglia belongs on every neuroscientist's bookshelf and will be a great asset for educators and neurological clinicians as well.

Author Biography

Helmut Kettenmann, PhD, Research Group Leader, Cellular Neurosciences, Max-Delbrück-Centrum for Molecular Neuroscience, Berlin, Germany.

Bruce R. Ransom, MD, PhD, Warren and Jermaine Magnuson Professor and Chair, Department of Neurology, University of Washington School of Medicine, Seattle, WA

Table of Contents

Foreword to Ed. 3Introduction

Properties of Neuroglial Cells

Evolution of glial cells: insights from invertebrate glia

Evolution of glial cells

Invertebrate glia

Non-mammalian, vertebrate glia

Morphology, Ultrastructure and Identification

Astrocyctes and Ependymal Glia

Radial glial cells

Structure and Function of Oligodendrocytes

Schwann cells and myelin

Microglial Cells

Pericytes of the central nervous system

NG2 Cells (Polydendrocytes)

Glial Cells in autonomic and sensory ganglia

Lineage and development

Astrocyte Development

Lineage and development: Oligodendrocytes

The Schwann Cell Lineage: Cellular Transitions During Development and After Injury

Microglia Lineage and Development

Physiological Properties

Physiology of astrocytes: Ion channels and ion transporters

Release of gliotransmitters and transmitter receptors in astrocytes

Storage and release of non-transmitter signaling molecules from macroglia

Physiology of microglia

Physiology of Oligodendrocytes

Physiological Properties of NG2+ Glial Cells

Cytokine, chemokine and growth factor receptors and signaling

Lipids, lipid mediators and other signaling molecules

Gap Junctions and Hemichannels

Purinergic Mechanisms in Glial Cells

Calcium signalling in neuroglia

The Central Role of Astrocytes in Neuroenergetics

Genomic Profiles

The Astrocyte Transcriptome

Gene expression patterns of oligodendrocyte progenitor cells and oligodendroglia

Functions of Neuroglial Cells

Outer Subventricular Zone Radial Glial Cells

Glial control of synaptogenesis

Neuron Migration and Axon Guidance

The Role of Glia in the Formation and Function of the Blood-Brain Barrier

Control of the extracellular ionic environment and volume

Amino Acid Neurotransmitter Synthesis and Removal

Glycogen and Energy Metabolism

Astrocyte regulation of neurovascular control

Modulation of synaptic function and network activity

Astrocytic modulation of mammalian synapses circuits and behaviors

Adult neurogenesis

Modulation of neuroendocrine systems

Oligodendrocytes/Schwann cells

Myelin, Impulse Conduction, and the Pathophysiology of Demyelination

Transcription factors in myelinating cells

Factors controlling myelin formation

Regulation of Myelination by Functional Activity

Iron and Glia

Microglia

Role of microglia in the normal brain

Factors controlling microglial activation

Roles of activated microglia

Immune functions of microglia

Role of glial cells in disease

Mechanisms of glial injury

Astrocyte Responses to CNS Injury and Disease

Metabolic injury of oligodendrocytes and myelin

Interaction of microglia with neurons and astrocytes under lesioned neuronal conditions

Schwann cells and injury

Recovery of Neural Function

Nerve Regeneration in the Peripheral Nervous System

Nerve fibre regeneration in the CNS of higher vertebrates

Glial Cell Transplantation for CNS Repair

Diseases

Focal cerebral ischemia: The multifaceted role of glial cells

Gliomas

Malignant Glioma

Glial tumors in Neurofibromatosis and Tuberous Sclerosis Complex

Demyelinating diseases

Multiple Sclerosis

Genetic mutations affecting myelin formation

Neurodegenerative Diseases

Amyotrophic Lateral Sclerosis (ALS)

Alzheimer's disease

Huntington disease, Parkinson disease and other neurodegenerative diseases

Infectious diseases

Glia in Bacterial and Viral CNS Infections

Miscellaneous diseases

Neuroglia in Hepatic Encephalopathy

Microglia and Pain

Genetic disorders affecting astrocytes

Epilepsy

Psychiatric Disorders

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