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Stereological methods provide researchers with unparalleled quantitative data from tissue samples and allow for well-evidenced research advances in a broad range of scientific fields. Presenting a concise introduction to the methodology and application of stereological research in neuroscience, Neurostereology provides a fuller understanding of the use of these methods in research and a means for replicating successful scientific approaches. Providing sound footing for future research, Neurostereology is a useful tool for basic and clinical researchers and advanced students looking to integrate these methods into their research.
Table of Contents
1. The History Of Neurostereology
Peter R. Mouton. Professor of Stereology, Byrd Alzheimer’s Disease Center at the University of South Florida, Tampa, Florida.
PART I: NOVEL NEUROSTEREOLOGY TECHNIQUES
2. Comparison of volume and surface area of the newborn brain using both Cavalieri principle and semiautomatic segmentation.
Niyazi Acer. Erciyes University, Medical faculty, Anatomy department, Kayseri, Turkey.
3. Stereology Analysis Of Neurogenesis.
Shozo Jinno. Department of Medical Sciences, Kyushu University, Fukuoka, Japan
4. Possible Applications (And Pitfalls!) Of Stereological Analysis In Post-Mortem Brain Research.
Ahmad Khundakar. University of Newcastle, Newcastle, England, U.K.
5. Modification Of AGNOR Staining To Reveal The Nucleolus In Thick Sections Specified For Stereological Assessment Of Dopaminergic Neurotoxicity In Substantia Nigra, Pars Compacta.
Robert Switzer. NeuroScience Associates, Knoxville, TN.
6. Quantitative Caveats Of Standard Immunohistochemical Procedures: Implications For Optical Disector-Based Designs.
Neal Melvin. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
7. Brain Banking: Making The Most Of Your Research Specimens.
Mark W. Burke. Department of Physiology, Howard University College of Medicine, Washington, D.C.
8. The Effects Of Ageing on Neuronal Markers in Substantia Nigra In Brains of Asian Indians.
Phalguni Anand Alladi. Advanced Centre for Neuroscience, Department of Neurophysiology, NIMHANS, Bangalore, India.
9. Modern Pathology Methods For Neural Investigations.
Mark Butt. Tox Path Specialists, Walkersville, MD.
10. Visualisation And Stereological Assessment Of Blood And Lymphatic Vessels.
Zerina Lokmic. University of Melbourne and St Vincent's Hospital Department of Surgery, Fitzroy, Victoria, Australia.
PART II: HUMAN AGING AND NEUROLOGICAL DISEASE
11. Selective Neuron Loss In The Paraventricular Nucleus Of The Hypothalamus Of Patients Suffering From Depression And Bipolar Disorder.
Kebreten F. Manaye1 & Peter R. Mouton2. 1Howard University College of Medicine, Washington, DC; 2Byrd Alzheimer’s Center at the University of South Florida, Tampa, FL.
12. Quantitative MRI Of The Prefrontal Cortex And Executive Function In Patients With Temporal Lobe Epilepsy.
Simon Keller. Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Pembroke Place, Liverpool L69 3BX, UK.
13. Stereology Of Cerebral Cortex After Traumatic Brain Injury Matched To The Glasgow Outcome Score.
William Maxwell. Department of Anatomy, Institute of Biomedical and Life Sciences, Gilmorehill, Glasgow, G12 8QQ, UK.
14. Quantification of Vascular Beds: A Stereological Approach.
Peter Dockery. Department of Anatomy, National University of Ireland, Galway, Ireland, UK.
15. An Overabundance Of Prefrontal Cortex Neurons Underlies Early Brain Overgrowth In Autism.
Eric Courchesne1 & Peter R. Mouton2. 1Department of Neuroscience, University of California at San Diego, San Diego, CA. 2Byrd Alzheimer’s Center at the University of South Florida, Tampa, FL;
16. Stereology Of Von Economo Neurons In Autism Spectrum Disorders.
Patrick Hof. Mount Sinai School of Medicine, New York, NY.
PART III: COMPARATIVE NEUROANATOMY
17. A Stereological Comparative Study Of Neocortex From The Harp Seal (Pagophilus Groenlandicus), Minke Whale (Balaenoptera acutorostrata), And Harbor Porpoise (Phocoena Phocoena).
Nina Eriksen. Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark.
18. Neuron numbers in the hypothalamus of the normal aging rhesus monkey: Stability across the adult life-span and between the sexes.
Douglas Rosene. Department of Neurobiology, Boston University, Boston, MA.
19. Human Neural Stem Cell Transplantation Ameliorates Radiation-Induced Cognitive Dysfunction.
Munjal M. Acharya. Department of Radiation Oncology, University of California, Irvine, Irvine, CA.
PART IV: ANIMAL MODELS OF NEUROLOGICAL DISEASE
20. Stereological Counts of TH-positive Neurons in Rodent Model of Parkinson’s Disease.
S. Omar Ahmad. Department of Occupational Science and Occupational Therapy Education, Saint Louis University, MO.
21. Neuron Loss In Two Mouse Models of AD-type ß-Amyloid Deposition.
Peter R. Mouton1 & Kebreten F. Manaye2. 1Byrd Alzheimer’s Center at the University of South Florida, Tampa, FL; 2Howard University College of Medicine, Washington, DC.