Oral Drug Absorption: Prediction and Assessment, Second Edition

by Dressman; Jennifer B.

• ISBN13: 9781420077339
• ISBN10: 1420077333
• Edition: 2nd
• Format: Hardcover
• Copyright: 2010-03-25
• Publisher: CRC Press

Summary

The much anticipated Second Edition of Oral Drug Absorption thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. Case-based examples and a supplementary interactive CD-ROM are included to provide real-life approaches to testing.

Author Biography

Jennifer B. Dressman Ph.D. is Professor of Pharmaceutical Technology and Director of the Institute of Pharmaceutical Technology at the Goethe University in Frankfurt am Main, Germany. She received her B. Pharm degree in Pharmacy from the Victorian College of Pharmacy, Melbourne, Australia in 1976 and her Ph.D. in 1980 from the University of Kansas. From 1980 to 1983 she held positions as Senior Scientist at Burroughs Wellcome and Interx/Merck before joining the Pharmaceutics Faculty at the University of Michigan as an Assistant Professor. In 1989 she was promoted to Associate Professor, with tenure, at the University of Michigan and in 1994 took up her current position. She has been invited as Visiting Scientist or Professor at the NIHS in Tokyo (1987), the University of Paris XI (1992), Glaxo RD (UK)and the University of Clermont-Ferrand (1998). Additionally, she works closely with the WHO on projects designed to improve the quality of medicines globally. Her research has been recognized by several awards, including the Ebert Prize (1987), Fellowship in the AAPS (1991), Phoenix Prize (2003), and the Distinguished Scientist Award of the FIP (2008). She is coauthor of more than 150 peer reviewed papers, three books and thirteen patents. Christos Reppas Ph.D is Associate Professor of Pharmaceutics, Faculty of Pharmacy, at the National and Kapodistrian (NK) University of Athens, Greece. He received his B. Pharm degree in Pharmacy (1982) and his Ph.D (1986) from NK University of Athens. From 1988 to 1989, he completed a postdoctoral fellowship in Pharmaceutics at the University of Michigan and then he joined the NK University of Athens in 1989 as a lecturer. He has held research positions with the University of London, the University of Michigan, Glaxo Research and Development, and Goethe University in Frankfurt am Main, Germany. He is coauthor of more than 70 peer-reviewed papers, two books, and one patent.

Table of Contents

Physiology of Oral Drug Absorption

General Gastrointestinal Physiology relevant to drug absorption

Absorption mechanisms in the GI tract

Gastrointestinal Transit and Drug Absorption

Gut Wall Metabolism

Food effects on dosage form performance

Diseases affecting drug absorption

The Biopharmaceutics Classification System

The Biopharmaceutics Classification Scheme

Solubility in the GI tract

Permeability measurement

In vivo biopharmaceutics: Experience from intestinal perfusion in humans

Alternatives to BCS using First Pass metabolism in the gut and liver

I Non-clinical methods to evaluate oral formulations

Dissolution testing to forecast in vivo performance of IR formulations

Dissolution testing to forecast in vivo performance of MR formulations

Analysis of Drug Dissolution Data

Formulation Screening in the Pharmaceutical Industry I

Formulation Screening in the Pharmaceutical Industry II

Animal models for screening oral formulations an update

Computer models for predicting drug absorption

Bioequivalence studies

Bioavailability and Bioequivalence studies

Biowaiving based on the BCS A Global Comparison

Biowaiving based on IVIVC

Appendix: Excel sheet programme (as CD)

Table of Contents provided by Publisher. All Rights Reserved.