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Andrew Brent, Specialist Registrar in Infectious Diseases Nuffield Department of Infectious Diseases & Microbiology and Centre for Tropical Medicine, Oxford, UK,Robert Davidson, Consultant Physician, Northwick Park Hospital; Hon Sen Lecturer, Imperial College School of Medicine, London, UK,Anna Seale, WT Research Training Fellow, Oxford University; KEMRI-Wellcome, CGMR-Coast, Kilifi, Kenya