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TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC).
RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation.
JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.
Table of Contents
Chapter 1: Introduction to pharmacogenomics of drug transporters
Marianne K DeGorter and Richard B Kim
Chapter 2: ADME Pharmacogenomics in Drug Development
Liangfu Chen and Joseph W. Polli
Chapter 3: Regulatory Perspective on Pharmacogenomics of Drug Metabolizing Enzymes and Transporters
Lei Zhang, Gilbert J. Burckart, Shiew-Mei Huang and Lawrence J. Lesko
Chapter 4: The Pharmacogenomics of Membrane Transporters Project
Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini
Chapter 5: Emerging new technology of SNP typing
Toshihisa Ishikawa and Yoshihide Hayashizaki
Chapters 6: OATP1A2, OAT1 and OAT3
Rommel G. Tirona
Chapter 7: OATP1B1, OATB1B3 and OATP2B1
Jörg König and Martin Fromm
Chapter 8: OCT (SLC22A) and OCTN Families
Sophie L. Stocker, Kathleen M. Giacomini, Arian Emami-Riedmaier and A. Matthias Schwab
Chapter 9: MATE (SLC47) FamilyAtsushi Yonezawa andKen-ichi Inui
Chapter 10: PEPT (SLC15A) Family
Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato
Chapter 11: Nucleoside Transporters (SLC28 and SLC29) Family
Míriam Molina-Arcas and Marçal Pastor-Anglada
Chapter 12: P-Glycoprotein (MDR1/ABCB1)
Chapter 13: Bile Salt Export Pump BSEP (ABCB11): Role in Liver Physiology and Liver Disease
Gerd Ullak-Kublick and Bruno Stieger
Chapter 14: BCRP (ABCG2)
Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom
Chapter 15: MRP2 (ABCC2) and MRP3 (ABCC3)
Anne T. Nies
Chapter 16: MRP4 (ABCC4)
Satish B.Cheepala, Mugdha Sukthankar and John D. Schuetz
Chapter 17: MRP8 (ABCC11)
Yu Toyoda and Toshihisa Ishikawa
Chapter 18: Future Perspectives
Toshihisa Ishikawa and Joseph Ware