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Pharmacology for Nursing Care

by
Edition:
4th
ISBN13:

9780721689975

ISBN10:
0721689973
Format:
Hardcover
Pub. Date:
1/1/2001
Publisher(s):
Elsevier Science Health Science div
List Price: $65.95
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Summary

Highly engaging and readable, this text provides a solid understanding of pharmacology its implications for patient care and patient education. A focus on "need-to-know" information and a drug-prototype approach make this book extremely popular with students and instructors alike. The new edition's updates and enhancements make it better than ever! This edition brings comprehensive revisions throughout to reflect up-to-the-minute drug information including hundreds of new indications, side effects, dosage forms, pediatric dosages, and patient implications, plus the facts on over 100 drugs newly approved by the FDA. Also features a brand-new unit on women's health that covers estrogens and progestins, birth control, drugs for infertility, and uterine stimulants and relaxants. Includes new chapters on pain management, herbal preparations, and the management of obesity, new "Special Interest" boxes that present engaging, real-life examples of drug application and use, and a new, dedicated worldwide web site, SIMON, for continuous updates and new drug releases. Includes 6 months' FREE online access to Mosby's Drug Consult , a comprehensive drug database. (Includes a FREE SIMON website at:www.harcourthealth.com/SIMON/Lehne/)

Table of Contents

Unit I Introduction
Orientation to Pharmacology
1(4)
Four Basic Terms
1(1)
Properties of an Ideal Drug
2(1)
The Therapeutic Objective
3(1)
Factors That Determine the Intensity of Drug Responses
3(2)
Application of Pharmacology in Nursing Practice
5(6)
Evolution of Nursing Responsibilities Regarding Drugs
5(1)
Application of Pharmacology in Patient Care
6(2)
Application of Pharmacology in Patient Education
8(3)
Pharmacology and the Nursing Process
11(6)
Review of the Nursing Process
11(1)
Application of the Nursing Process in Drug Therapy
12(3)
Use of a Modified Nursing Process Format to Summarize Nursing Implications in This Text
15(2)
Drug Regulation Legislation, Development, Names, and Information
17(10)
Landmark Drug Legislation
17(1)
New Drug Development
18(2)
Drug Names
20(3)
Over-the-Counter Drugs
23(1)
Sources of Drug Information
24(3)
Unit II Basic Principles of Pharmacology
Pharmacokinetics
27(20)
Application of Pharmacokinetics in Therapeutics
27(1)
A Note to Chemophobes
28(1)
Passage of Drugs Across Membranes
28(3)
Absorption
31(5)
Distribution
36(3)
Metabolism
39(1)
Excretion
40(2)
Time Course of Drug Responses
42(5)
Pharmacodynamics
47(12)
Dose-Response Relationships
47(2)
Drug-Receptor Interactions
49(6)
Drug Responses That Do Not Involve Receptors
55(1)
Interpatient Variability in Drug Responses
55(1)
The Therapeutic Index
56(3)
Drug-Drug and Drug-Food Interactions
59(8)
Drug-Drug Interactions
59(4)
Drug-Food Interactions
63(4)
Adverse Drug Reactions
67(6)
Scope of the Problem
67(1)
Definitions
67(3)
Identifying Adverse Drug Reactions
70(1)
Adverse Reactions to New Drugs
70(1)
Ways to Minimize Adverse Drug Reactions
70(3)
Individual Variation in Drug Responses
73(6)
Body Weight and Composition
73(1)
Age
73(1)
Gender
73(1)
Pathophysiology
74(1)
Tolerance
75(1)
Placebo Effect
76(1)
Genetics
76(1)
Variability in Absorption
76(1)
Failure to Take Medicine as Prescribed
77(1)
Drug Interactions
78(1)
Diet
78(1)
Unit III Drug Therapy Across the Life Span
Drug Therapy During Pregnancy and Breast-Feeding
79(6)
Drug Therapy During Pregnancy: Basic Considerations
79(1)
Drug Therapy During Pregnancy: Teratogenesis
80(3)
Drug Therapy During Breast-Feeding
83(2)
Drug Therapy in Pediatric Patients
85(4)
Pharmacokinetics: Neonates and Infants
85(2)
Pharmacokinetics: Children 1 Year and Older
87(1)
Adverse Drug Reactions
87(1)
Dosage Determination
87(1)
Promoting Compliance
88(1)
Drug Therapy in Geriatric Patients
89(4)
Pharmacokinetic Changes in the Elderly
89(1)
Pharmacodynamic Changes in the Elderly
90(1)
Adverse Drug Reactions and Drug Interactions
90(1)
Promoting Compliance
91(2)
Unit IV Peripheral Nervous System Drugs
Introduction
Basic Principles of Neuropharmacology
93(6)
How Neurons Regulate Physiologic Processes
93(1)
Basic Mechanisms by Which Neuropharmacologic Agents Act
94(2)
Multiple Receptor Types and Selectivity of Drug Action
96(1)
An Approach to Learning about Peripheral Nervous System Drugs
97(2)
Physiology of the Peripheral Nervous System
99(16)
Divisions of the Nervous System
99(1)
Overview of Autonomic Nervous System Functions
99(1)
Basic Mechanisms by Which the Autonomic Nervous System Regulates Physiologic Processes
100(1)
Anatomic Considerations
101(1)
Introduction to Transmitters of the Peripheral Nervous System
102(1)
Introduction to Receptors of the Peripheral Nervous System
103(1)
Exploring the Concept of Receptor Subtypes
104(2)
Locations of Receptor Subtypes
106(1)
Functions of Cholinergic and Adrenergic Receptor Subtypes
106(3)
Receptor Specificity of the Adrenergic Transmitters
109(1)
Transmitter Life Cycles
110(5)
Cholinergic Drugs
Muscarinic Agonists and Antagonists
115(8)
Muscarinic Agonists
115(2)
Muscarinic Antagonists
117(6)
Cholinesterase Inhibitors and Their Use in Myasthenia Gravis
123(8)
Reversible Cholinesterase Inhibitors
123(3)
``Irreversible'' Cholinesterase Inhibitors
126(2)
Myasthenia Gravis
128(3)
Neuromuscular Blocking Agents and Ganglionic Blocking Agents
131(12)
Neuromuscular Blocking Agents
131(5)
Depolarizing Neuromuscular Blockers: Succinylcholine
136(2)
Ganglionic Blocking Agents
138(5)
Adrenergic Drugs
Adrenergic Agonists
143(14)
Mechanisms of Adrenergic Receptor Activation
143(1)
Overview of the Adrenergic Agonists
144(2)
Therapeutic Applications and Adverse Effects of Adrenergic Receptor Activation
146(3)
Properties of Representative Adrenergic Agonists
149(4)
Discussion of Adrenergic Agonists in Other Chapters
153(4)
Adrenergic Antagonists
157(12)
Alpha-Adrenergic Antagonists I: Therapeutic and Adverse Responses to Alpha Blockade
157(2)
Alpha-Adrenergic Antagonists II: Properties of Individual Alpha Blockers
159(1)
Beta-Adrenergic Antagonists I: Therapeutic and Adverse Responses to Beta Blockade
160(2)
Beta-Adrenergic Antagonists II: Properties of Individual Beta Blockers
162(7)
Indirect-Acting Antiadrenergic Agents
169(8)
Adrenergic Neuron-Blocking Agents
169(2)
Centrally Acting Alpha2 Agonists
171(6)
Unit V Central Nervous System Drugs
Introduction
Introduction to Central Nervous System Pharmacology
177(4)
Transmitters of the CNS
177(1)
The Blood-Brain Barrier
177(1)
How Do CNS Drugs Produce Therapeutic Effects?
178(1)
Adaptation of the CNS to Prolonged Drug Exposure
178(1)
Development of New Psychotherapeutic Drugs
178(1)
Approaching the Study of CNS Drugs
179(2)
Neurologic Drugs
Drugs for Parkinson's Disease
181(14)
Pathophysiology of Parkinson's Disease
181(1)
Overview of Drug Therapy
181(1)
Basic Pharmacology of the Drugs Used to Treat Parkinson's Disease
182(10)
Drug Selection
192(3)
Drugs for Epilepsy
195(20)
Seizure Generation
195(1)
Types of Seizures
196(1)
How Antiepileptic Drugs Work
196(1)
General Therapeutic Considerations
197(2)
Basic Pharmacology of the Major Antiepileptic Drugs
199(9)
Antiseizure Therapy During Pregnancy
208(1)
Generalized Convulsive Status Epilepticus
208(7)
Drugs for Muscle Spasm and Spasticity
215(6)
Drug Therapy of Muscle Spasm: Centrally Acting Muscle Relaxants
215(1)
Drugs for Spasticity
216(5)
Drugs for Headache
221(10)
Migraine Headache I: Characteristics and Overview of Treatment
221(1)
Migraine Headache II: Abortive Therapy
222(4)
Migraine Headache III: Prophylactic Therapy
226(1)
Cluster Headaches
227(1)
Tension-Type Headache
227(4)
Anesthetics and Analgesics
Local Anesthetics
231(8)
Basic Pharmacology of the Local Anesthetics
231(3)
Properties of Individual Local Anesthetics
234(1)
Clinical Use of Local Anesthetics
235(4)
General Anesthetics
239(10)
Basic Pharmacology of the Inhalation Anesthetics
239(4)
Properties of Individual Inhalation Anesthetics
243(2)
Intravenous Anesthetics
245(4)
Opioid (Narcotic) Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics
249(24)
Introduction to the Opioids
249(1)
Basic Pharmacology of the Opioids
250(12)
Clinical Use of Opioids
262(4)
Opioid Antagonists
266(2)
Nonopioid Centrally Acting Analgesics
268(5)
Pain Management in Patients With Cancer
273(20)
Pathophysiology of Pain
273(1)
Overall Treatment Strategy
274(2)
Assessment and Ongoing Evaluation
276(2)
Drug Therapy
278(8)
Nondrug Therapy
286(1)
Pain Management in Special Populations
287(2)
Patient Education
289(4)
Psychotherapeutic Drugs
Antipsychotic Agents and Their Use in Schizophrenia
293(18)
Schizophrenia: Clinical Features and Etiology
293(2)
Conventional Antipsychotic Agents I: Group Properties
295(5)
Conventional Antipsychotic Agents II: Properties of Individual Agents
300(2)
Atypical Antipsychotic Agents
302(2)
Management of Schizophrenia
304(7)
Antidepressants
311(20)
Major Depression: Clinical Features, Pathogenesis, and Treatment Modalities
311(1)
Tricyclic Antidepressants
312(5)
Selective Serotonin Reuptake Inhibitors
317(4)
Monoamine Oxidase Inhibitors
321(2)
Atypical Antidepressants
323(3)
Electroconvulsive Therapy
326(5)
Drugs for Bipolar Disorder
331(8)
Bipolar Disorder (Manic-Depressive Illness)
331(1)
Lithium
332(3)
Anticonvulsants
335(4)
Benzodiazepines and Other Drugs for Anxiety and Insomnia
339(20)
Benzodiazepines
339(5)
Barbiturates
344(3)
Nonbenzodiazepine-Nonbarbiturates
347(2)
Management of Anxiety
349(1)
Management of Insomnia
350(9)
Central Nervous System Stimulants and Their Use in Attention-Deficit/Hyperactivity Disorder
359(10)
Amphetamines
359(2)
Methylphenidate
361(1)
Methylxanthines
361(2)
Miscellaneous CNS Stimulants
363(1)
Attention-Deficit/Hyperactivity Disorder
364(5)
Other Psychologic Disorders: Panic Disorder, Obsessive-Compulsive Disorder, and Alzheimer's Disease
369(8)
Panic Disorder
369(1)
Obsessive-Compulsive Disorder
370(2)
Alzheimer's Disease
372(5)
Drug Abuse
Drug Abuse: Basic Considerations
377(6)
Definitions
377(1)
Diagnostic Criteria for Substance Abuse and Substance Dependence
378(1)
Factors Contributing to Drug Abuse
378(2)
Approaches to Modifying Drug-Using Behavior
380(1)
The Controlled Substances Act
380(3)
Drug Abuse: Alcohol
383(10)
Basic Pharmacology of Alcohol
383(5)
Alcohol Abuse
388(1)
Drugs Used in the Treatment of Alcohol Abuse
389(4)
Drug Abuse: Opioids, Depressants, Psychostimulants, Marijuana, Psychedelics, Inhalants, and Nicotine
393(20)
Opioids
393(4)
General CNS Depressants
397(1)
Psychostimulants
398(3)
Marijuana and Related Preparations
401(1)
Psychedelics
402(2)
Phencyclidine
404(1)
Inhalants
405(1)
Nicotine and Smoking
406(4)
Anabolic Steroids
410(3)
Unit VI Drugs That Affect Fluid and Electrolyte Balance
Diuretics
413(14)
Review of Renal Anatomy and Physiology
413(3)
Introduction to Diuretics
416(1)
High-Ceiling (Loop) Diuretics
416(2)
Thiazides and Related Diuretics
418(2)
Potassium-Sparing Diuretics
420(2)
Osmotic Diuretics
422(5)
Agents Affecting the Volume and Ion Content of Body Fluids
427(6)
Disorders of Fluid Volume and Osmolality
427(1)
Acid-Base Disturbances
428(1)
Potassium Imbalances
429(1)
Magnesium Imbalances
430(3)
Unit VII Drugs That Affect the Heart, Blood Vessels, and Blood
Review of Hemodynamics
433(8)
Overview of the Circulatory System
433(2)
Regulation of Cardiac Output
435(1)
Regulation of Arterial Pressure
436(5)
Drugs Acting on the Renin-Angiotensin System
441(10)
Physiology of the Renin-Angiotensin System
441(3)
Angiotensin-Converting Enzyme Inhibitors
444(3)
Angiotenisn II Receptor Blockers
447(4)
Calcium Channel Blockers
451(10)
Calcium Channels: Physiologic Functions and Consequences of Blockade
451(1)
Calcium Channel Blockers: Classification and Sites of Action
452(1)
Verapamil and Diltiazem: Agents That Act on Vascular Smooth Muscle and the Heart
453(2)
Dihydropyridines: Agents That Act Mainly on Vascular Smooth Muscle
455(6)
Vasodilators
461(8)
Basic Concepts in Vasodilator Pharmacology
461(2)
Pharmacology of Individual Vasodilators
463(6)
Drugs for Hypertension
469(22)
Hypertension: Definition, Types, and Consequences
469(2)
Objectives of Antihypertensive Therapy
471(1)
Risk Stratification and Selection of Treatment Modality
471(1)
Management of Essential Hypertension I: Lifestyle Modifications
471(2)
Management of Essential Hypertension II: Pharmacologic Therapy
473(12)
Drugs for Hypertensive Emergencies
485(1)
Drugs for Hypertensive Disorders of Pregnancy
486(5)
Drugs for Angina Pectoris
491(14)
Determinants of Cardiac Oxygen Demand and Oxygen Supply
491(1)
Angina Pectoris: Pathophysiology and Treatment Strategy
491(3)
Organic Nitrates
494(4)
Beta Blockers
498(1)
Calcium Channel Blockers
499(1)
Revascularization Therapy: CABG and PTCA
499(1)
Summary of Treatment Measures
500(5)
Drugs for Heart Failure
505(16)
Pathophysiology of Heart Failure
505(2)
Treatment Goals and Strategies
507(1)
Nondrug Therapy of Heart Failure
507(1)
Evaluating Treatment of Heart Failure
508(1)
Overview of Drugs Used to Treat Heart Failure
508(3)
Drug Selection in Chronic Heart Failure
511(1)
Pharmacology of the Cardiac (Digitalis) Glycosides
512(9)
Antidysrhythmic Drugs
521(20)
Electrical Properties of the Heart
521(3)
Generation of Dysrhythmias
524(2)
Classification of Antidysrhythmic Drugs
526(1)
Prodysrhythmic Effects of Antidysrhythmic Drugs
526(1)
Overview of Common Dysrhythmias and Their Treatment
527(2)
Class I: Sodium Channel Blockers
529(4)
Class II: Beta Blockers
533(1)
Class III: Potassim Channel Blockers (Drugs That Delay Repolarization)
534(1)
Class IV: Calcium Channel Blockers
535(1)
Principles of Antidysrhythmic Drug Therapy
536(1)
Nonpharmacologic Treatment of Sysrhythmias
537(4)
Prophylaxis of Coronary Artery Disease: Drugs That Lower LDL Cholesterol Levels
541(18)
Cholesterol
541(1)
Plasma Lipoproteins
542(1)
Role of LDL Cholesterol in Atherosclerosis
543(1)
Cholesterol Testing and Follow-up
544(1)
Management of High LDL Cholesterol
545(2)
Drugs and Other Lipid-Lowering Products
547(12)
Anticoagulant, Antiplatelet, and Thrombolytic Drugs
559(24)
Physiology and Pathophysiology of Coagulation
559(2)
Overview of Drugs Used to Treat Thromboembolic Disorders
561(5)
Parenteral Anticoagulants
566(1)
Oral Anticoagulants
566(5)
Antiplatelet Drugs
571(3)
Thrombolytic Drugs
574(9)
Management of Myocardial Infarction
583(6)
Pathophysiology of Myocardial Infarction
583(1)
Diagnosis of Myocardial Infarction
583(1)
Management of Myocardial Infarction
584(2)
Complications of Myocardial Infarction
586(1)
Risk Reduction
587(2)
Drugs for Deficiency Anemias
589(14)
Red Blood Cell Development
589(1)
Iron Deficiency
589(6)
Vitamin B12 Deficiency
595(3)
Folic Acid Deficiency
598(5)
Hematopoietic and Thrombopoietic Growth Factors
603(8)
Hematopoietic Growth Factors
603(4)
Thrombopoietic Growth Factors
607(4)
Unit VIII Drugs for Endocrine Disorders
Drugs for Diabetes Mellitus
611(24)
Diabetes Mellitus: Overview of the Disease and Its Treatment
611(5)
Insulin
616(7)
Oral Hypoglycemics
623(5)
Diabetic Ketoacidosis
628(1)
Glucagon for Insulin Overdose
629(6)
Drugs for Thyroid Disorders
635(14)
Thyroid Physiology
635(2)
Thyroid Pathophysiology
637(2)
Thyroid Function Tests
639(1)
Thyroid Hormone Preparations for Hypothyroidism
640(2)
Drugs for Hyperthyroidism
642(7)
Drugs Related to Hypothalamic and Pituitary Function
649(10)
Overview of Hypothalamic and Pituitary Endocrinology
649(1)
Growth Hormone
650(3)
Prolactin
653(1)
Thyrotropin
653(1)
Corticotropin
653(1)
Gonadotropins
654(1)
Antidiuretic Hormone
654(1)
Oxytocin
655(1)
Drugs Related to Hypothalamic Function
655(4)
Drugs for Disorders of the Adrenal Cortex
659(8)
Physiology of the Adrenocortical Hormones
659(2)
Pathophysiology of the Adrenocortical Hormones
661(2)
Agents for Replacement Therapy in Adrenocortical Insufficiency
663(1)
Agents for Diagnostic Testing of Adrenocortical Function
664(1)
Inhibitors of Corticosteroid Synthesis
665(2)
Androgens
667(10)
Testosterone
667(1)
Clinical Pharmacology of the Androgens
668(3)
Androgen (Anabolic Steroid) Abuse by Athletes
671(6)
Unit IX Women's Health
Estrogens and Progestins
677(14)
The Menstrual Cycle
677(1)
Estrogens
678(2)
Selective Estrogen Receptor Modulators (SERMs)
680(1)
Progestins
681(1)
Hormone Replacement Therapy After Menopause
682(9)
Birth Control
691(14)
Effectiveness and Safety of Birth Control Methods
691(1)
Selecting a Birth Control Method
692(1)
Oral Contraceptives
693(5)
Long-Acting Contraceptives
698(1)
Spermicides
699(1)
Barrier Devices
699(1)
Drugs for Medical Abortion
700(5)
Drug Therapy of Infertility
705(10)
Infertility: Causes and Treatment Strategies
705(2)
Drugs Used to Treat Female Infertility
707(8)
Uterine Stimulants and Relaxants
715(8)
Uterine Stimulants (Oxytocics)
715(3)
Uterine Relaxants (Tocolytics) and Their Use in Preterm Labor
718(5)
Unit X Anti-inflammatory, Antiallergic, and Immunologic Drugs
Review of the Immune System
723(12)
Introduction to the Immune System
723(5)
Antibody-Mediated (Humoral) Immunity
728(3)
Cell-Mediated Immunity
731(4)
Pediatric Immunization
735(14)
General Considerations
735(2)
Target Diseases
737(3)
Specific Vaccines and Toxoids
740(9)
Immunosuppressants
749(8)
Cyclosporine and Tacrolimus
749(2)
Glucocorticoids
751(1)
Cytotoxic Drugs
752(1)
Antibodies
752(5)
Anthistamines
757(8)
Histamine
757(2)
The Two Types of Antihistamines: H1 Antagonists and H2 Antagonists
759(1)
H1 Antagonists I: Basic Pharmacology
759(2)
H1 Antagonists II: Preparations
761(4)
Cyclooxygenase Inhibitors: Nonsteroidal Anti-inflamatory Drugs and Acetaminophen
765(16)
Mechanism of Action
765(1)
Classification of Cyclooxygenase Inhibitors
766(1)
First-Generation NSAIDs
766(9)
Second-Generation NSAIDs (COX-2 Inhibitors)
775(1)
Acetaminophen
776(5)
Glucocorticoids in Nonendocrine Diseases
781(12)
Review of Glucocorticoid Physiology
781(1)
Pharmacology of the Glucocorticoids
782(11)
Unit XI Drugs for Bone and Joint Disorders
Drug Therapy of Rheumatoid Arthritis and Gout
793(10)
Drug Therapy of Rheumatoid Arthiritis
793(2)
Pharmacology of the Drugs Used for Rheumatoid Arthritis
795(4)
Drug Therapy of Gout
799(4)
Drugs Affecting Calcium Levels and Bone Mineralization
803(20)
Calcium Physiology
803(2)
Calcium-Related Pathophysiology
805(1)
Drugs for Disorders Involving Calcium
806(8)
Osteoporosis
814(9)
Unit XII Respiratory Tract Drugs
Drugs for Asthma
823(16)
Pathophysiology of Asthma
823(1)
Overview of Drugs for Asthma
823(1)
Administration of Drugs by Inhalation
824(1)
Beta2-Adrenergic Agonists
825(1)
Glucocorticoids
826(2)
Cromolyn
828(1)
Nedocromil
829(1)
Methylxanthines
829(1)
Ipratropium
830(1)
Leukotriene Modifiers
831(1)
Management of Asthma
831(8)
Drugs for Allergic Rhinitis, Cough, and Colds
839(8)
Drugs for Allergic Rhinitis
839(4)
Drugs for Cough
843(1)
Cold Remedies: Combination Preparations
844(3)
Unit XIII Gastrointestinal Drugs
Drugs for Peptic Ulcer Disease
847(14)
Pathogenesis of Peptic Ulcers
847(1)
Overview of Treatment
848(2)
Antibacterial Drugs
850(1)
Histamine2-Recepto Antagonists
851(2)
Proton Pump Inhibitors
853(1)
Other Antiulcer Drugs
854(7)
Laxatives
861(8)
General Considerations
861(1)
Basic Pharmacology of Laxatives
862(4)
Laxative Abuse
866(3)
Other Gastrointestinal Drugs
869(12)
Prokinetic Agents
869(1)
Antiemetics
870(4)
Drugs for Motion Sickness
874(1)
Antidiarheal Agents
875(1)
Drugs for Inflammatory Bowel Disease
876(2)
Pancreatic Enzymes
878(1)
Drugs Used to Dissolve Gallstones
879(1)
Anorectal Preparations
879(2)
Unit XIV Nutrition
Vitamins
881(10)
General Considerations
881(1)
Fat-Soluble Vitamins
882(5)
Water-Soluble Vitamins
887(4)
Enteral and Parenteral Nutrition
891(4)
Enteral Nutritional Therapy
891(1)
Parenteral Nutritional Therapy
892(3)
Drugs for Obesity
895(10)
Assessment of Obesity-Related Health Risk
895(2)
Overview of Treatment
897(1)
Appetite Suppressants
898(3)
Orlistat, A Lipase Inhibitor
901(1)
Leptin
902(1)
Calorie-Saving Foods
902(3)
Unit XV Chemotherapy of Infectious Diseases
Basic Principles of Antimicrobial Therapy
905(14)
Selective Toxicity
905(1)
Classification of Antimicrobial Drugs
906(1)
Acquired Resistance to Antimicrobial Drugs
907(2)
Selection of Antibiotics
909(4)
Host Factors That Modify Drug Choice, Route of Administration, or Dosage
913(1)
Dosage Size and Duration of Treatment
914(1)
Therapy with Antibiotic Combinations
915(1)
Prophylactic Use of Antimicrobial Drugs
915(1)
Misuses of Antimicrobial Drugs
916(1)
Monitoring Antimicrobial Therapy
916(3)
Drugs That Weaken the Bacterial Cell Wall I: Penicillins
919(12)
Introduction to the Penicillins
919(2)
Properties of Individual Penicillins
921(10)
Drugs That Weaken the Bacterial Cell Wall II: Cephalosporins, Imipenem, Aztreonam, Vancomycin, Teicoplanin, and Fosfomycin
931(10)
Cephalosporins
931(4)
Other Inhibitors of Cell Wall Synthesis
935(6)
Bacteriostatic Inhibitors of Protein Synthesis: Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Spectinomycin, and Dalflopristin/Quinupristin
941(14)
Tetracyclines
941(4)
Macrolides
945(2)
Clindamycin
947(1)
Chloramphenicol
948(1)
Spectinomycin
949(1)
Dalflopristin/Quinupristin
950(5)
Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis
955(8)
Basic Pharmacology of the Aminoglycosides
955(4)
Properties of Individual Aminoglycosides
959(4)
Sulfonamids and Trimethoprim
963(8)
Sulfonamides
963(3)
Trimethoprim
966(1)
Trimethoprim-Sulfamethoxazole
967(4)
Drug Therapy of Urinary Tract Infections
971(8)
Organisms That Cause Urinary Tract Infections
971(1)
Overview of the Drugs Used to Treat Urinary Tract Infections
971(1)
Specific Urinary Tract Infections and Their Treatment
972(3)
Urinary Tract Antispetics
975(4)
Antimycobacterial Agents: Drugs for Tuberculosis, Leprosy, and Mycobacterium avium Complex Infection
979(16)
Tuberculosis I: Clinical Considerations
979(4)
Tuberculosis II: Pharmacology of Individual Antituberculosis Drugs
983(6)
Drugs for Leprosy (Hansen's Disease)
989(1)
Drugs for Mycobacterium avium Complex Infection
990(5)
Miscellaneous Antibacterial Drugs: Fluroquinolones, Rifampin, Metronidazole, Polymyxins, and Bacitracin
995(6)
Fluroquinolones
995(2)
Additional Antibacterial Drugs
997(4)
Antifungal Agents
1001(12)
Drugs for Systemic Mycoses
1001(5)
Drugs for Superficial Mycoses
1006(7)
Antiviral Agents I: Drugs for Non-HIV Viral Infections
1013(14)
Purine Nucleoside Analogs (DNA Polymerase Inhibitors)
1013(4)
Drugs for Hepatitis B and C
1017(2)
Drugs for Influenza
1019(2)
Ophthalmic Antiviral Drugs
1021(1)
Other Antiviral Drugs
1022(5)
Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections
1027(36)
Pathophysiology
1028(3)
Classification of Antiretroviral Drugs
1031(1)
Nucleoside Reverse Transcriptase Inhibitors
1031(5)
Non-nucleoside Reverse Transcriptase Inhibitors
1036(2)
Protease Inhibitors
1038(6)
Management of HIV Infection
1044(9)
Prophylaxis and Treatment of Opportunistic Infections
1053(3)
HIV Vaccines
1056(1)
Keeping Current
1057(6)
Drug Therapy of Sexually Transmitted Diseases
1063(8)
Chalmydia Trachomatis Infections
1063(3)
Gonococcal Infections
1066(1)
NOngonococcal Urethritis
1067(1)
Pelvic Inflammatory Disease
1067(1)
Acute Epididymitis
1068(1)
Syphilis
1068(1)
Acquired Immunodeficiency Syndrome
1068(1)
Chancroid
1068(1)
Trichomoniasis
1069(1)
Bacterial Vaginosis
1069(1)
Hepes Simplex Infections
1069(1)
Genital and Anal Warts (Condyloma Acuminatum)
1069(1)
Proctitis
1070(1)
Pediculosis Pubis and Scabies
1070(1)
Antiseptics and Disinfectants
1071(6)
General Considerations
1071(1)
Properties of Individual Antiseptics and Disinfectants
1072(5)
Unit XVI Chemotherapy of Parasitic Diseases
Anthelmintics
1077(6)
Classification of Parasitic Worms
1077(1)
Helminthic Infestations
1078(1)
Drugs of Choice for Helminthiasis
1079(4)
Antiprotozoal Drugs I: Antimalarial Agents
1083(8)
Life Cycle of the Malaria Parasite
1083(1)
Types of Malaria
1084(1)
Principles of Antimalarial Therapy
1085(1)
Pharmacology of the Major Antimalarial Drugs
1086(5)
Antiprotozoal Drugs II: Miscellaneous Agents
1091(6)
Protozoal Infections
1091(1)
Drugs of Choice for Protozoal Infections
1092(5)
Ectoparasiticides
1097(4)
Ectoparasitic Infestations
1097(1)
Pharmacology of Ectoparasiticides
1098(3)
Unit XVII Cancer Chemotherapy
Basic Principles of Cancer Chemotherapy
1101(14)
What Is Cancer?
1102(1)
The Growth Fraction and Its Relationship to Chemotherapy
1103(1)
Obstacles to Successful Chemotherapy
1104(3)
Strategies for Achieving Maximum Benefits from Chemotherapy
1107(2)
Major Toxicities of the Anticancer Drugs and Their Management
1109(3)
Making the Decision to Treat
1112(1)
Looking Ahead
1113(2)
Anticancer Drugs
1115(26)
Introduction to the Cytotoxic Drugs
1115(3)
Alkylanting Agents
1118(3)
Antimetabolities
1121(3)
Antitumor Antibiotics
1124(2)
Mitotic Inhibitors
1126(2)
Miscellaneous Cytotoxic Drugs
1128(1)
Hormones and Hormone Antagonists
1129(5)
Biologic Response Modifiers: Immunostimulants
1134(7)
Unit XVIII Additional Important Drugs
Drugs for the Eye
1141(10)
Glaucoma and Its Treatment
1141(6)
Cycloplegics and Mydriatics
1147(1)
Additional Ophthalmic Drugs
1148(3)
Drugs for the Skin
1151(12)
Anatomy of the Skin
1151(1)
Topical Glucocorticoids
1151(2)
Keratolytic Agents
1153(1)
Acne and Its Treatment
1153(3)
Psoriasis and Its Treatment
1156(2)
Miscellaneous Dermatologic Drugs
1158(5)
Miscellaneous Noteworthy Drugs
1163(8)
Drugs for Erectile Dysfunction
1163(2)
Drugs for Benign Prostatic Hyperplasia
1165(2)
Drugs for Neonatal Respiratory Distress Syndrome
1167(1)
Drugs for Cystic Fibrosis
1168(1)
Riluzole for Amyotropic Lateral Sclerosis
1169(2)
Unit XIX Alternative Therapy
Herbal Supplements
1171(12)
Limited Regulation: The Dietary Supplement Health and Education Act
1172(1)
Adverse Interactions with Conventional Drugs
1173(1)
Oral Formulations
1174(1)
Standardization of Herbal Products
1174(1)
Dosage
1174(1)
Commonly Used Medicinal Herbs
1174(9)
Unit XX Toxicology
Management of Poisoning
1183(48)
Fundamentals of Treatment
1183(1)
Drugs and Procedures Used to Minimize Poison Absorption
1184(1)
Drugs and Procedures Used for Poison Removal
1185(1)
Specific Antidotes
1185(3)
Poison Control Centers
1188(1)
Appendices
A Guide to Gender-Related Drugs
1189(1)
B Weights and Measures
1190(1)
C Laboratory Reference Values
1191(5)
D Commonly Used Abbreviations
1196(2)
E Techniques of Drug Administration
1198(6)
F Poison Control Centers in the United States
1204(8)
G Canadian Drug Information
1212(14)
H Major Drug Classes and Their Prototypes
1226(5)
Index 1231


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